Visualization of transepidermal invasion of fluorescent HIV and development of the new HIV entry inhibitor
| Project/Area Number |
23591641
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 性行為HIV感染 / Langerhans cells / Maraviroc / EFdA / CCR5阻害薬 / HIV / ランゲルハンス細胞 / マイクロビサイド / ＨＩＶ / Langerhans cell / 可視化 / HIV侵入阻害薬 |
|---|
| Research Abstract |
It became clear that Langerhans cells (LCs) in the epidermis of volunteer, who took Maraviroc (MVC), had very strong resistance for HIV infection, suggesting that MVC; the agent developed as an AIDS therapeutic drug has been demonstrated as a useful oral micro beside. In addition, in the in vitro HIV infection experiment with monocyte-derived LCs, it was suggested that EFdA and MVC had a superior suppressant effect against HIV infection, and that EFdA can be practically used as micro beside.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells2014
Author(s)
Takaki M, Inozume T, Matsuzawa T, Ando N, Y amaguchi M, Harada K, Kawamura T, Shibagaki N, Shimada S
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Journal Title
J Dermatol
Volume: (In press)
Issue: 6
Pages: 529-532
DOI
Related Report
Peer Reviewed
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[Journal Article] EFdA, a reverse transcriptase inhibitor , potently blocks HIV -1 ex vivo infection of Langerhans cells within epithelium2014
Author(s)
Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H
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Journal Title
J Invest Dermatol
Volume: 134(4)
Issue: 4
Pages: 1158-61
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oral administration of the CCR5 inhibitor , maraviroc, blocks HIV ex vivo infection of Langerhans cells within the epithelium2013
Author(s)
Matsuzawa T, Kawamura T, Ogawa Y, Takahashi M, Aoki R, Moriishi K, Koyanagi Y, Gatanaga H, Blauvelt A, Shimada S
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Journal Title
J Invest Dermatol
Volume: 133(12)
Issue: 12
Pages: 2803-5
DOI
Related Report
Peer Reviewed
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