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Visualization of transepidermal invasion of fluorescent HIV and development of the new HIV entry inhibitor

Research Project

Project/Area Number 23591641
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionUniversity of Yamanashi

Principal Investigator

KAWAMURA Tatsuyoshi  山梨大学, 医学部附属病院, 講師 (70262657)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords性行為HIV感染 / Langerhans cells / Maraviroc / EFdA / CCR5阻害薬 / HIV / ランゲルハンス細胞 / マイクロビサイド / HIV / Langerhans cell / 可視化 / HIV侵入阻害薬
Research Abstract

It became clear that Langerhans cells (LCs) in the epidermis of volunteer, who took Maraviroc (MVC), had very strong resistance for HIV infection, suggesting that MVC; the agent developed as an AIDS therapeutic drug has been demonstrated as a useful oral micro beside. In addition, in the in vitro HIV infection experiment with monocyte-derived LCs, it was suggested that EFdA and MVC had a superior suppressant effect against HIV infection, and that EFdA can be practically used as micro beside.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] A case of oral mucosal fixed eruption caused by methacrylate2014

    • Author(s)
      Inozume T, Nakazawa R, Tanaka K, Harada K, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      Contact Dermatitis

      Volume: 70(6) Issue: 6 Pages: 387-8

    • DOI

      10.1111/cod.12183

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells2014

    • Author(s)
      Takaki M, Inozume T, Matsuzawa T, Ando N, Y amaguchi M, Harada K, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      J Dermatol

      Volume: (In press) Issue: 6 Pages: 529-532

    • DOI

      10.1111/1346-8138.12493

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] EFdA, a reverse transcriptase inhibitor , potently blocks HIV -1 ex vivo infection of Langerhans cells within epithelium2014

    • Author(s)
      Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H
    • Journal Title

      J Invest Dermatol

      Volume: 134(4) Issue: 4 Pages: 1158-61

    • DOI

      10.1038/jid.2013.467

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral administration of the CCR5 inhibitor , maraviroc, blocks HIV ex vivo infection of Langerhans cells within the epithelium2013

    • Author(s)
      Matsuzawa T, Kawamura T, Ogawa Y, Takahashi M, Aoki R, Moriishi K, Koyanagi Y, Gatanaga H, Blauvelt A, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 133(12) Issue: 12 Pages: 2803-5

    • DOI

      10.1038/jid.2013.215

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of autosomal recessive woolly hair with LIPH gene mutations2013

    • Author(s)
      Harada K, Inozume T, Kawamura T, Shibagaki N, Kinoshita T, Deguchi N, Shimada S
    • Journal Title

      Int J Dermatol

      Volume: 52(5) Pages: 572-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production2013

    • Author(s)
      Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 133(9) Issue: 9 Pages: 2170-9

    • DOI

      10.1038/jid.2013.150

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial peptide LL-37 produced by HSV-2-infected keratinocytes enhances HIV infection of Langerhans cells2013

    • Author(s)
      Ogawa Y, Kawamura T, Matsuzawa T, Aoki R, Gee P, Yamashita A, Moriishi K, Yamasaki K, Koyanagi Y. Blauvelt A, Shimada S.
    • Journal Title

      Cell Host and Microbe

      Volume: 13 Issue: 1 Pages: 77-86

    • DOI

      10.1016/j.chom.2012.12.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of dermatomyositis accompanied by spontaneous intramuscular hemorrhage despite normal coagulability2013

    • Author(s)
      Hanawa F, Inozume T, Harada K, Andou N, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      Rheumatol Int

      Volume: 33(11) Issue: 11 Pages: 2949-50

    • DOI

      10.1007/s00296-012-2492-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Case of rheumatoid papules : is this a link between vasculitis and rheumatoid nodules?2012

    • Author(s)
      Inozume T, Ando N, Sano S, Harada K, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      J Dermatol

      Volume: 39(12) Pages: 1091-2

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophilic panniculitis with non-caseating granulomas in a Crohn's disease patient2012

    • Author(s)
      Ogawa Y, Aoki R, Harada K, Matsuzawa T, Inozume T, Shibagaki N, Kawamura T, Shimada S
    • Journal Title

      Eur J Dermatol

      Volume: 22(3) Issue: 3 Pages: 404-5

    • DOI

      10.1684/ejd.2012.1737

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gutter method : noninvasive management of ingrown nails caused by epidermal growth factor inhibitor treatment2012

    • Author(s)
      Harada K, Yamaguchi M, Miyajima S, Kawamura T, Shibagaki S, Shimada S
    • Journal Title

      Clin Exp Dermatol

      Volume: 37(6) Pages: 703-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Case of mucous membrane pemphigoid characterized by circulating immunoglobulin A and immunoglobulin G autoantibodies to the gamma-2 subunit of laminin-3322012

    • Author(s)
      Hanawa F, Harada K, Andou N, Kawamura T, Shibagaki N, Fukuda S, Hashimoto T, Shimada S
    • Journal Title

      J Dermatol

      Volume: 39(11) Pages: 962-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sev ere dermatitis with loss of epidermal Langerh ans cells in human and mouse zinc deficiency.2011

    • Author(s)
      Kawamura T, Ohta Y, et al.
    • Journal Title

      The Journal of Clinical Investigation

      Volume: 84 Issue: 2 Pages: 722-732

    • DOI

      10.1172/jci58618

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] The roles of Langerhans cell in acrodermatitis enteropathica and HIV infection2013

    • Author(s)
      T. Kawamura
    • Organizer
      The 11^<th> International Symposium of the Cutaneous Biology Research Institute
    • Place of Presentation
      Seoul
    • Related Report
      2013 Final Research Report
  • [Presentation] HIVの生体内侵入メカニズムと新たな感染予防戦略2013

    • Author(s)
      川村龍吉
    • Organizer
      第37回 阿蘇シンポジウム
    • Place of Presentation
      阿蘇グランヴィリオホテル (熊本)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Strategies for preventing sexual transmission of HIV2012

    • Author(s)
      T. Kawamura
    • Organizer
      13th KUMAMOTO AIDS Seminar
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel strategy to prevent sexual transmission of HIV-1 by oral administration of CCR5 inhibitor2011

    • Author(s)
      T. Matsuzawa, T. Kawamura, R. Aoki, Y. Ogawa, M. Takahashi, Y. Koyanagi, A. Blauvelt, H. Gatanaga and S. Shimada
    • Organizer
      The 36th Japanese Society for Investigative Dermatology Annual Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Remarks] 皮膚科学講座 - 山梨大学 医学部

    • URL

      http://www.med.yamanashi.ac.jp/clinical/dermatol/index.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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