| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
1.Lrig1, a negative feedback regulator of the ErbB receptor family, was highly expressed by hair follicle and intestinal stem cells and controls the size of their niche by regulating the amplitude of growth factor signalling. MED1 is expressed by human epidermal keratinocytes and functions as a coactivator of several transcription factors. Med1 knockout mice provided an strong evidece that MED1 plays an important role in maintaining quiescence of keratinocytes and preventing depletion of the follicular stem cells.
2.Production of leptin, a well-known adipokine, by dermal papilla cells increased under hypoxic condition, suggesting that hypoxia in catagen/telogen phase promotes leptin production by dermal papilla, preparing for entry into the next anagen.
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