Does fibronectin activated by dermatopontin have anti-tumor activity?
| Project/Area Number |
23591648
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Sakuhei 大分大学, 医学部, 教授 (90181411)
松尾 哲孝 大分大学, 医学部, 准教授 (10284788)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Noritaka 大分大学, 医学部, 准教授 (10284788)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 細胞外マトリックス / デルマトポンチン / フィブロネクチン / フィブリン / 創傷治癒 |
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| Research Abstract |
We found that dermatopontin interacts with fibronectin and activates it (Kato, J. Biol. Chem. 2011, Okamoto, Astetic Dermatol. 2011). The activated fibronectin decreased the number of vessels in melanoma tumor inoculated on the back of mice.
We also found that dermatopontin interacts with fibrinogen. Dermatopontin accelerated fibrin fibril formation and the diameters of newly-formed fibrin fibrils became greater than those formed under normal condition. The fibrin fibrils enhanced human umbilical vein endothelial cell adhesion and the cell spreading (Wu, J. Invest. Dermatol. 2014).
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Dermatopontin Interacts with Fibronectin,Promotes Fibronectin Fibril Formation,and Enhances Cell Adhesion2011
Author(s)
Kato A,Okamoto O,Ishikawa K,Sumiyoshi H,Matsuo N,Yoshioka H,Nomizu M,Shimada T,and Fujiwara S
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Journal Title
The Journal of Biological Chemistry
Volume: 286(17)
Pages: 14861-14869
Related Report
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[Journal Article] Dermatopontin interacts with fibronectin, promotes fibronectin fibril formation, and enhances cell adhesion.2011
Author(s)
Kato A, Okamoto O, Ishikawa K, Sumiyoshi H, Matsuo N, Yoshioka H, Nomizu M, Shimada T, Fujiwara S.
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Journal Title
J. Biol. Chem.
Volume: 286
Pages: 14861-14869
Related Report
Peer Reviewed
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