| Project/Area Number |
23591650
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nara Medical University |
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Principal Investigator |
ASADA HIDEO 奈良県立医科大学, 医学部, 教授 (60252681)
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| Co-Investigator(Kenkyū-buntansha) |
MORII Takeshi 奈良県立医科大学, 医学部, 講師 (70264851)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 薬剤性過敏症症候 / DIHS / GVHD / HHV-6 / ヒトヘルペスウイルス / 再活性化 / 制御性T細胞 / TARC / 薬剤性過敏症症候群 / HHV-7 |
|---|
| Research Abstract |
HHV-6 reactivation plays an important role in the pathogenesis of drug induced hypersensitivity syndrome(DIHS). In this study, we aimed to elucidate the mechanism of HHV-6 reactivation in DIHS. As a result, we observed infiltration of regulatory T cells (Treg) into the skin lesion in the period leading up to the HHV-6 reactivation from the onset of DIHS, and a marked increase of TARC, a chemokine involved in the migration of Treg, during the acute phase, and a close correlation between serum TARC levels and HHV-6 reactivation. These results suggest the possibility that TARC itself, or the immune modulation following the increase of TARC plays an important role in HHV-6 reactivation in DIHS.
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