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Cutaneous immunoregulatory functions of a novel antimicrobial agent, catestatin

Research Project

Project/Area Number 23591655
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionJuntendo University

Principal Investigator

NIYONSABA FRANCOIS  順天堂大学, 医学(系)研究科(研究院), 准教授 (60365640)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords抗菌ペプチド / 皮膚免疫 / 自然免疫 / ケラチノサイト / 好中球 / 抗菌物質 / マスト細胞
Research Abstract

Catestatin, initially believed to act as an neuroendocrine regulator, is an antimicrobial agent found in the skin keratinocytes and fibroblasts, and is over-expressed during wound healing and infection. In this study, we observed that Catestatin and the newly discovered antimicrobial peptides known as IDRs stimulated various functions of human keratinocytes and neutrophils, leading to the wound healing acceleration. Thus, in addition to their microbiocidal properties, skin-derived antimicrobial agents might also participate to the regulation of cutaneous host defense, inflammation and innate immune system through activation of keratinocytes.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (18 results) (of which Invited: 1 results)

  • [Journal Article] Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes2013

    • Author(s)
      Xue Chen
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 433 Issue: 4 Pages: 532-537

    • DOI

      10.1016/j.bbrc.2013.03.024

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions.2013

    • Author(s)
      Niyonsaba F, Madera L, Afacan N, Okumura K, Ogawa H, Hancock RE.
    • Journal Title

      J Leukoc Biol

      Volume: 94 Issue: 1 Pages: 159-70

    • DOI

      10.1189/jlb.1012497

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of neutrophil apoptosis by antimicrobial peptides.2012

    • Author(s)
      Isao Nagaoka
    • Journal Title

      ISRN Microbiology

      Volume: 2012 Pages: 12-12

    • DOI

      10.5402/2012/345791

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB2012

    • Author(s)
      Nguyen TT
    • Journal Title

      J Dermatol Sci

      Volume: 68 Issue: 1 Pages: 63-6

    • DOI

      10.1016/j.jdermsci.2012.07.010

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes2011

    • Author(s)
      Hoq Md Imranul
    • Journal Title

      JOURNAL OF DERMATOLOGICAL SCIENCE

      Volume: 64 Issue: 2 Pages: 108-118

    • DOI

      10.1016/j.jdermsci.2011.08.001

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes2011

    • Author(s)
      Hoq MI, Niyonsaba F, Ushio H, Aung G, Okumura K, Ogawa H
    • Journal Title

      Journal for Dermatological Science

      Volume: 64 (2) Pages: 108-118

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases2011

    • Author(s)
      Aung G, Niyonsaba F, Ushio H, Hoq MI, Ikeda S, Ogawa H, Okumura K.
    • Journal Title

      Journal for Dermatological Science

      Volume: 61(2) Pages: 142-144

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Synthetic immunomodulatory peptides IDR-HH2, IDR-1002 and IDR-1018 regulate neutrophil functions2013

    • Author(s)
      Niyonsaba F, Madera L, Okumura K, Ogawa H, Hancock REW
    • Organizer
      15^<th> International Congress of Immunology
    • Place of Presentation
      ミラノ, イタリア
    • Year and Date
      2013-08-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthetic immunomodulatory peptides IDR-HH2, IDR-1002 and IDR-1018 regulate neutrophil functions2013

    • Author(s)
      Niyonsaba F et al.
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      イタリア、ミラノ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of human β-defensins on interleukin-37 production by human keratinocytes2013

    • Author(s)
      SmithritheeR, Niyonsaba F et al.
    • Organizer
      2013 International Investigative Dermatology
    • Place of Presentation
      スコットランド、エジンバラ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human b-defensin-3 improves the epithelial tight junction (TJ) barrier through activation of glycogen synthase kinase-3 (GSK-3) and protein kinase C (PKC)2013

    • Author(s)
      Kiatsurayanon C, Niyonsaba F et al.
    • Organizer
      2013 International Investigative Dermatology
    • Place of Presentation
      スコットランド、エジンバラ
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-36 cytokines enhance the production of host defense peptides LL-37 and psoriasin by human keratinocytes through activation of MAPKs and NF-kB2013

    • Author(s)
      Akiyama T, Nguyen TT, Niyonsaba F
    • Organizer
      2013 International Investigative Dermatology
    • Place of Presentation
      スコットランド、エジンバラ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthetic innate defense regulator peptides modulate various functions of human neutrophils2012

    • Author(s)
      Niyonsaba F, Madera L, Okumura K, Ogawa H, Hancock REW
    • Organizer
      The 37^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル&スパタワー那覇, 沖縄
    • Year and Date
      2012-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of IL-36 cytokines on S100A7/psoriasin and cathelicidin LL-37 expression and production by primary human keratinocytes2012

    • Author(s)
      Nguyen TT, Niyonsaba F, Akiyama T, Smithrithee R, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H
    • Organizer
      The 37^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル&スパタワー那覇, 沖縄
    • Year and Date
      2012-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Innate defense regulator peptides modulate neutrophil functions2012

    • Author(s)
      Niyonsaba F, Madera L, Okumura K, Ogawa H, Hancock REW
    • Organizer
      第62日本アレルギー学会
    • Place of Presentation
      大阪国際会議場, 大阪
    • Year and Date
      2012-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Neuroendocrine antimicrobial peptide, catestatin, and its variants increase keratinocyte migration and proliferation2011

    • Author(s)
      Niyonsaba F, Hoq MI, Ushio H, Aung G, Okumura K, Ogawa H
    • Organizer
      The 36^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      国立京都国際会館, 京都
    • Year and Date
      2011-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Human catestatin induces epidermal keratinocyte migration and proliferation2011

    • Author(s)
      Niyonsaba F, Hoq MI, Ushio H, Aung G, Okumura K, Ogawa H
    • Organizer
      第39日本免疫学会総会第
    • Place of Presentation
      幕張メッセ, 千葉
    • Year and Date
      2011-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] ランチョンセミナー : ヒト抗菌物質の皮膚免疫調節機能に対する役割2011

    • Author(s)
      ニヨンサバフランソワ
    • Organizer
      第58回ドキシンシンポジウム
    • Place of Presentation
      順天堂大学, 東京
    • Year and Date
      2011-07-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Human catestatin induces epidermal keratinocyte migration and proliferation2011

    • Author(s)
      Niyonsaba F
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Research-status Report
  • [Presentation] Neuroendocrine antimicrobial peptide, catestatin, and its variants increase epidermal keratinocyte migration and proliferation2011

    • Author(s)
      Niyonsaba F
    • Organizer
      The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 教育講演:上皮細胞が産生する抗菌物質の免疫調節機能2011

    • Author(s)
      ニヨンサバ フランソワ
    • Organizer
      第39回日本耳鼻咽喉科感染症研究会(招待講演)
    • Place of Presentation
      ホテル東京ガーデンパレス
    • Related Report
      2011 Research-status Report
  • [Presentation] ランチョンセミナー:ヒト抗菌物質の皮膚免疫調節機能に対する役割2011

    • Author(s)
      ニヨンサバ フランソワ
    • Organizer
      第58回ドキシンシンポジウム(招待講演)
    • Place of Presentation
      順天堂大学 本郷キャンパス (東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthetic innate defense regulator peptides modulate various functions of human neutrophils

    • Author(s)
      Niyonsaba F
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      沖縄
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of IL-36 cytokines on S100A7/psoriasin and cathelicidin LL-37 expression and production by primary human keratinocytes

    • Author(s)
      Nguyen TT, Niyonsaba F et al.
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      沖縄
    • Related Report
      2012 Research-status Report
  • [Presentation] Novel roles of host defense peptides in cutaneous biology

    • Author(s)
      Niyonsaba F
    • Organizer
      IEIIS2012 Homeostatic Inflammation Symposium
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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