• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Combination of indocyanine green and gold nano-particles for diagnosis and treatment of tumors and vascular abnormality

Research Project

Project/Area Number 23591663
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionNational Defense Medical College

Principal Investigator

AZUMA Ryuichi  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 (00531112)

Co-Investigator(Kenkyū-buntansha) KIYOSAWA Tomoharu  防衛医科大学校病院, 准教授 (90221217)
MORIMOTO Yuji  防衛医科大学校, 医学科専門課程, 准教授 (10449069)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsインドシアニングリーン / 金ナノロッド / 近赤外レーザー / EPR効果 / 血管腫
Outline of Final Research Achievements

Infrared laser irradiation after intravenous administration of indocyanine green increases vascular permeability at skin and dermo-muscular layer of rats. Subsequently induced intravenous gold nano-rods and infrared laser irradiation effectively injure skin and subcutaneous tissue. This indicates that GNRs would be highly concentrated in the tissue by EPR effect. The effect exerts intensely at superficial layer of the skin and is unaffected by blood flow. Thus, this method could be available for drug delivery system on tissues which have poor blood flow.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2015 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Effective wound healing in streptozotocin-induced diabetic rats by adipose-derived stromal cell transplantation in plasma-gel containing fragmin/protamine microparticles.2015

    • Author(s)
      Sumi Yuki, Azuma Ryuichi et al
    • Journal Title

      annals of plastic surgery

      Volume: 72 Pages: 113-120

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effective Wound Healing in Streptozotocin-Induced Diabetic Rats by Adipose-Derived Stromal Cell Transplantation in Plasma-Gel Containing Fragmin/Protamine Microparticles2013

    • Author(s)
      東隆一
    • Journal Title

      Annals of plastic surgery

      Volume: 72 Pages: 113-120

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transplantation of inbred adipose-derived stromal cells in rats with plasma gel containing fragmin/protamine microparticles and FGF-22013

    • Author(s)
      東隆一
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: 101 Pages: 784-791

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ICG蛍光造影法による腸管の血流評価2015

    • Author(s)
      東隆一 他
    • Organizer
      第58回日本形成外科学会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-08 – 2015-04-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] インドシアニングリーン血管造影法を用いた穿通枝皮弁のデザイン2013

    • Author(s)
      東隆一
    • Organizer
      日本形成外科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi