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Analyses of lipid network using inflammatory dermatoses model mice

Research Project

Project/Area Number 23591665
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

YAMAMOTO Kei  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (30304504)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脂質代謝 / 脂質メディエーター / 皮膚疾患 / 接触性皮膚炎 / ホスホリパーゼA2 / 炎症収束 / 皮膚癌 / 乾癬 / ホスホリパーゼA2 / アレルギー / 質量分析 / リピドミクス / アトピー性皮膚炎 / モデルマウス
Research Abstract

Epidermal lipids play important roles in skin barrier and pathophysiological function. Although perturbed lipid metabolism often leads to skin abnormality, molecular mechanisms underlying this process still remain incompletely understood. In this research, we show that secreted PLA2 group IID (PLA2G2D) is preferentially expressed in dendritic cells (DCs) and displays a pro-resolving function. In hapten-induced contact dermatitis, resolution of inflammation was compromised in skin and LNs of PLA2G2D-deficient mice, in which the immune balance was shifted toward a proinflammatory state over an anti-inflammatory state. PLA2G2D in the LNs contributed to mobilization of a pool of DHA that could serve as precursors for pro-resolving lipid mediators such as resolvin D1. Our results highlight PLA2G2D as a"resolving sPLA2" that ameliorates inflammation through mobilizing pro-resolving lipid mediators and points to a potential use of this enzyme for treatment of inflammatory disorders.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (68 results)

All 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (42 results) Book (1 results) Remarks (6 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Lymphoid tissue phospholipase A_2 group IID resolves contact hypersensitivity by driving anti-inflammatory lipid mediators2013

    • Author(s)
      Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J.M., Hara, S., Gelb, M.H., and Murakami, M.
    • Journal Title

      J. Exp. Med.

      Volume: 210 Pages: 1217-1234

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell maturation is driven via a group III phospholipase A_2-prostaglandin D_2-DP1 receptor paracrine axis2013

    • Author(s)
      Taketomi, Y., Ueno, N., Kojima, T., Satom H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M.H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., and Murakami, M.
    • Journal Title

      Nat. Immunol.

      Volume: 14 Pages: 554-563

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 疾病における脂質代謝ネットワークの機能2013

    • Author(s)
      三木寿美、山本圭、村上誠
    • Journal Title

      オレオサイエンス

      Volume: 13(10) Pages: 23-29

    • NAID

      130005122088

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators2013

    • Author(s)
      Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
    • Journal Title

      J Exp Med.

      Volume: 210 Issue: 6 Pages: 1217

    • DOI

      10.1084/jem.20121887

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.2013

    • Author(s)
      Taketomi, Y., Morimoto, K., Murakami, M., et al., 他30名
    • Journal Title

      Nature Immunol.

      Volume: (印刷中) Issue: 6 Pages: 554-63

    • DOI

      10.1038/ni.2586

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators2013

    • Author(s)
      Miki, Y., Yamamoto, K. et al
    • Journal Title

      J. Exp. Med.

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.2013

    • Author(s)
      Ait-Oufella H, Herbin O, Lahoute C, Coatrieux C, Loyer X, Joffre J, Laurans L, Ramkhelawon B, Blanc-Brude O, Karabina S, Girard CA, Payré C, Yamamoto K, Binder CJ, Murakami M, Tedgui A, Lambeau G, Mallat Z.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Issue: 3 Pages: 466-473

    • DOI

      10.1161/atvbaha.112.300309

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin2011

    • Author(s)
      Yamamoto, K., Taketomi, T., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 13 Pages: 11616-11631

    • DOI

      10.1074/jbc.m110.206714

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Physiological roles of group X secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function2011

    • Author(s)
      Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 13 Pages: 11632-11648

    • DOI

      10.1074/jbc.m110.206755

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2alpha, not iPLA2beta, to lipid mobilization in proximal mast cells and distal fibroblasts.2011

    • Author(s)
      Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 186 Issue: 43 Pages: 37249-37263

    • DOI

      10.1074/jbc.m111.290312

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secreted phospholipase A_2 revisited2011

    • Author(s)
      Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
    • Journal Title

      J. Biochem.

      Volume: 150 Issue: 3 Pages: 233-255

    • DOI

      10.1093/jb/mvr088

    • NAID

      10030587186

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology2011

    • Author(s)
      Murakami, M., et al
    • Journal Title

      Int.J.Mol.Sci.

      Volume: 12 Issue: 3 Pages: 1474-1495

    • DOI

      10.3390/ijms12031474

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secreted phospholipase A_2, lipoprotein hydrolysis, and atherosclerosis : integration with lipidomics2011

    • Author(s)
      Yamamoto, K., et al
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: 400 Issue: 7 Pages: 1829-1842

    • DOI

      10.1007/s00216-011-4864-z

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent progress in phospholipase A_2 research : from cells to animals to humans2011

    • Author(s)
      Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., and Yamamoto, K.
    • Journal Title

      Prog. Lipid Res

      Volume: 50 Issue: 2 Pages: 152-192

    • DOI

      10.1016/j.plipres.2010.12.001

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ホスホリパーゼA22011

    • Author(s)
      山本圭
    • Journal Title

      生化学

      Volume: 83 Pages: 449-461

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity

    • Author(s)
      Sato, H., Taketomi, Y., Ushida, A., Isogai, Y., Kojima, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Nishito, Y., Kobayashi, T., Ikeda, K., Taguchi, R., Hara, S., Ida, S., Miyamoto, Y., Watanabe, M., Baba, H., Miyata, K., Oike, Y., Gelb, M.H., and Murakami, M.
    • Journal Title

      Cell Metabolism

      Volume: (in press) Pages: 2014-2014

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Epidermal phospholipase A_2 group IIF regulates keratinocyte differentiation and skin barrier through driving a unique set of lipid products2013

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau, G, and Murakami, M.
    • Organizer
      16th GEM/10th GERLI meeting 2013 GEM/GERLI Lipidomics meeting
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Epidermal phospholipase A_2 group IIF regulates keratinocyte differentiation and skin barrier through driving a unique set of lipid products2013

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau, G, and Murakami, M.
    • Organizer
      13^<th> International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
    • Place of Presentation
      San Juan, Puerto Rico
    • Related Report
      2013 Final Research Report
  • [Presentation] IIF型分泌性ホスホリパーゼA_2は皮膚疾患の進行に寄与する2013

    • Author(s)
      山本圭、三木寿美、佐藤真利子、椛島健治、石川由起雄、石井壽晴、村上誠
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] IIF型分泌性ホスホリパーゼA_2は表皮の恒常性維持および病態に寄与する2013

    • Author(s)
      山本圭、三木寿美、佐藤真利子、武富芳隆、池田和貴、中西広樹、田口良、村上誠
    • Organizer
      第55回日本脂質生化学会
    • Place of Presentation
      宮城県松島町
    • Related Report
      2013 Final Research Report
  • [Presentation] GROUP IIF PHOSPHOLIPASE A_2 MAINTAINS SKIN HOMEOSTASIS2013

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau, G. and Murakami, M.
    • Organizer
      5th International Conference on Phospholipase A_2 Mediates Signaling in Translational Medicine
    • Place of Presentation
      New Orleans(米国)
    • Related Report
      2013 Final Research Report
  • [Presentation] GROUP IIF PHOSPHOLIPASE A2 MAINTAINS SKIN HOMEOSTASIS.2013

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau, G. and Murakami, M.
    • Organizer
      5th International Conference on Phospholipase A2 Mediates Signaling in Translational Medicine
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] IIF型分泌性ホスホリパーゼA2は表皮の恒常性維持および病態に寄与する2013

    • Author(s)
      山本圭、三木寿美、佐藤真利子、武富芳隆、池田和貴、中西広樹、田口良、村上誠
    • Organizer
      第55回日本脂質生化学会
    • Place of Presentation
      宮城県松島町
    • Related Report
      2013 Annual Research Report
  • [Presentation] IIF型分泌性ホスホリパーゼA2は皮膚疾患の進行に寄与する2013

    • Author(s)
      山本圭、三木寿美、佐藤真利子、椛島健治、石川由起雄、石井壽晴、村上誠
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Epidermal phospholipase A2 group IIF regulates keratinocyte differentiation and skin barrier through driving a unique set of lipid products.2013

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau, G, and Murakami, M.
    • Organizer
      13th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases.
    • Place of Presentation
      San Juan, Pueruto Rico
    • Related Report
      2013 Annual Research Report
  • [Presentation] Epidermal phospholipase A2 group IIF regulates keratinocyte differentiation and skin barrier through driving a unique set of lipid products.2013

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau, G, and Murakami, M
    • Organizer
      16th GEM/10th GERLI meeting 2013 GEM/GERLI Lipidomics meeting.
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] GROUP IIF PHOSPHOLIPASE A2 MAINTAINS SKIN HOMEOSTASIS2013

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau G., and Murakami, M.
    • Organizer
      5th International Conference on Phospholipase A2 Mediated Signaling in Translational Medicine
    • Place of Presentation
      New Orleans
    • Related Report
      2012 Research-status Report
  • [Presentation] IIF型分泌性ホスホリパーゼA2は表皮の恒常性維持および病態に寄与する2013

    • Author(s)
      山本圭、三木寿美、佐藤真利子、武富芳隆、池田和貴、中西広樹、田口良、村上誠
    • Organizer
      第55回日本脂質生化学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 皮膚病態生理機能におけるIIE型分泌性ホスホリパーゼA_2の役割2012

    • Author(s)
      山本圭、佐藤弘泰、佐藤真利子、三木寿美、武富芳隆、村上誠
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮膚病態生理機能におけるIIE型分泌性ホスホリパーゼA2の役割2012

    • Author(s)
      山本圭、佐藤弘泰、佐藤真利子、三木寿美、武富芳隆、村上誠
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Secreted phospholipase A_2s in skin homeostasis2011

    • Author(s)
      Yamamoto, K., Shimo, K., Miki, Y., Sato, M., Taketomi, Y., Ikeda, K., Nakanishi, H., Taguchi, R., Gelb, M.H., Lambeau, G., and Murakami, M.
    • Organizer
      New Aspect of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin2011

    • Author(s)
      Yamamoto, K., Taketomi, Y., Miki, Y., Sato, H., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
    • Organizer
      The 8^<th> GERLI Lipidomics meeting
    • Place of Presentation
      Lyon, France
    • Year and Date
      2011-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Group IIF phospholipase A_2 maintains epidermal homeostasis2011

    • Author(s)
      Yamamoto, K., Shimo, K., Miki, Y., Taketomi, Y., Ikeda, K., Nakanishi, H., Taguchi, R., Gelb, M.H., Lambeau, G., and Murakami, M.
    • Organizer
      The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮膚病態生理における分泌性ホスホリパーゼA2の機能

    • Author(s)
      山本圭
    • Organizer
      第84回日本生化学会(招待講演)
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 外根鞘に局在するsPLA2-Xは体毛の恒常性維持に関与する

    • Author(s)
      山本圭
    • Organizer
      第53回脂質生化学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 樹状細胞のsPLA2-IIDは炎症応答の寛解を制御する

    • Author(s)
      三木寿美
    • Organizer
      第53回脂質生化学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 脂肪過栄養により誘導されるsPLA2-Vは全身的な脂質代謝異常を制御する

    • Author(s)
      佐藤弘泰
    • Organizer
      第53回脂質生化学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Roles of multiple sPLA2 enzymes in obesity, hepatic steatosis, insulin tolerance, lipoprotein metabolism and adipose inflammation.

    • Author(s)
      Sato, H.
    • Organizer
      The 30th Naito Conference on Membrane Dynamics and Lipid Biology
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Metabolic pathways regulating formation and composition of lipid droplets in sebocytes.

    • Author(s)
      Hirabayashi, T.
    • Organizer
      The 30th Naito Conference on Membrane Dynamics and Lipid Biology
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Group IIF phospholipase A2 maintains epidermal homeostasis. The 12th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases.

    • Author(s)
      Yamamoto, K.
    • Organizer
      The 12th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases.
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Biology of group X secreted phospholipase A2: from physiology to cancer and inflammatory diseases.

    • Author(s)
      Lambeau, G.
    • Organizer
      The 12th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases.
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Getting new insights into the functions of sPLA2s.

    • Author(s)
      Murakami, M.
    • Organizer
      The 12th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases.
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] アトピー性皮膚炎モデルにおける分泌性ホスホリパーゼA2の機能解析.

    • Author(s)
      下華奈子
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] X型分泌性ホスホリパーゼA2の消化、神経機能、体毛形成における新規機能

    • Author(s)
      佐藤弘泰
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] X型分泌性ホスホリパーゼA2の生殖における新規機能.

    • Author(s)
      牛田絢子
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] ホスファチジルエタノールアミンは破骨細胞融合に関与する.

    • Author(s)
      入江敦
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] sPLA2-IIDは抗炎症性脂質の産生を制御して炎症応答の寛解に関与する

    • Author(s)
      三木寿美
    • Organizer
      ファーマ・バイオフォーラム2011
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.

    • Author(s)
      Yamamoto, K
    • Organizer
      The 8th GERLI Lipidomics meeting
    • Place of Presentation
      Lyon, France
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted Phospholipase A2 in epidermal differentiation, acidification, and barrier function.

    • Author(s)
      Murakami, M.
    • Organizer
      The 8th GERLI Lipidomics meeting
    • Place of Presentation
      Lyon, France
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A2s in skin homeostasis.

    • Author(s)
      Yamamoto, K.
    • Organizer
      New Aspect of Phospholipid Biology and Medicine 2011.
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A2s in atopic dermatitis.

    • Author(s)
      Shimo, K.
    • Organizer
      New Aspect of Phospholipid Biology and Medicine 2011.
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A2s in metabolic syndrome.

    • Author(s)
      Sato, H.
    • Organizer
      New Aspect of Phospholipid Biology and Medicine 2011.
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A2s in anaphylaxis.

    • Author(s)
      Taketomi, Y.
    • Organizer
      New Aspect of Phospholipid Biology and Medicine 2011.
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A2s in reproduction.

    • Author(s)
      Ushida, A.
    • Organizer
      New Aspect of Phospholipid Biology and Medicine 2011.
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] sPLA2と炎症収束

    • Author(s)
      三木寿美
    • Organizer
      新学術研究「脂質マシナリー」若手ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] sPLA2とアトピー性皮膚炎

    • Author(s)
      下華奈子
    • Organizer
      新学術研究「脂質マシナリー」若手ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] sPLA2とメタボリックシンドローム

    • Author(s)
      佐藤弘泰
    • Organizer
      新学術研究「脂質マシナリー」若手ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] sPLA2とアナフィラキシー

    • Author(s)
      武富芳隆
    • Organizer
      新学術研究「脂質マシナリー」若手ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] 論文ができてしまう!疾患モデルマウス表現型解析指南2011

    • Author(s)
      佐藤弘泰
    • Publisher
      中山書店
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/lipid

    • Related Report
      2013 Final Research Report
  • [Remarks] 体に蓄えられた魚の油が病気を止める ~体に優しい脂質を動かし炎症にブレーキをかける酵素の発見~

    • URL

      http://www.igakuken.or.jp/research/topics/2013/0524.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 体に優しい脂質を働かせ、炎症にブレーキをかける酵素の同定

    • URL

      http://www.igakuken.or.jp/lipid/research9.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] アレルギーを起こす新しい脂質代謝経路を解明 ~花粉症等アレルギー克服に向けての新しい創薬に期待~

    • URL

      http://www.igakuken.or.jp/research/topics/2013/0430.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] マスト細胞成熟経路の発見

    • URL

      http://www.igakuken.or.jp/lipid/reseacch8.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/lipid/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] PLA2G2Fを指標とした表皮角化細胞の過増殖性疾患に対する薬剤スクリーニング方法2013

    • Inventor(s)
      村上誠、山本圭
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Number
      2013-240871
    • Filing Date
      2013-11-21
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] PLA2G2Fを指標とした抗皮膚癌薬のスクリーニング方法2013

    • Inventor(s)
      村上誠、山本圭
    • Industrial Property Rights Holder
      村上誠、山本圭
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-21
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] PLA2G2Fを指標とした抗皮膚癌薬のスクリーニング方法2012

    • Inventor(s)
      村上誠、山本圭
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Number
      2012-255316
    • Filing Date
      2012-11-21
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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