| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of barrier tissue cells such as epithelial cells and endothelial cells. IL-33 passively released from damaged tissue has been shown to be acted as a cytokine. We found that IL-33 can act on epidermal keratinocytes and dermal microvascular endothelial cells to induce neutrophil-associated cytokine/chemokine productions.
Furthermore, we have established an in vitro scratch model of skin tissue cells, and found that keratinocyte extracts contained unidentified pro-inflammatory substances to mediate inflammatory responses to intact cultured skin tissue cells such as fibroblasts and microvascular endothelial cells. These findings suggest the existence of a molecular machinery of "itch-scratch cycle" in the inflammatory skin diseases such as atopic dermatitis.
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