Study on the molecular pathophysiology of schizophrenia based on the chiral-specific action of neutral amino acids
| Project/Area Number |
23591668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAMOTO Naoki 東京医科歯科大学, 医学部附属病院, 講師 (70312296)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | D－セリン / 統合失調症 / NMDA受容体 / D-セリン / グルタミン酸 / NMDA |
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| Outline of Final Research Achievements |
In this study I have focused on the chiral-specific action of neutral amino acids especially D-serine, a coagonist of NMDA type glutamate receptor, in the central nervous system to further understand pathophysiology of schizophrenia and to develop novel therapeutics. During the genetic study I have found some of the D-serine-NMDA receptor signal-related genes are associated with schizophrenia. In this study focusing on the chiral-specific agonistic action of neutral amino acids as well as the NMDA receptor antagonism by PCP, I further obtained some evidence that indicated possible heterogeneity of the disease-vulnerability based on the gender- and age of onset-stratified genetic approach.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] S1-1/RBM10: multiplicity and cooperativity of nuclear localisation domains.2013
Author(s)
Xiao SJ, Wang LY, Kimura M, Kojima H, Kunimoto H, Nishiumi F, Yamamoto N, Nishio K, Fujimoto S, Kato T, Kitagawa S, Yamane H, Nakajima K, Inoue A.
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Journal Title
Biol Cell.
Volume: 105
Pages: 162-174
Related Report
Peer Reviewed
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[Presentation] Identification of developmentally-regulated phencyclidine-inducible gene and its genetic association with schizophrenia.2013
Author(s)
Uezato, A, Kimura-Sato J, Hiraoka S, Yamamoto N, Kajii Y, Kuroda Y, Umino A, Iijima Y, Kunugi H, Nishikawa T.
Organizer
11th World Congress of Biological Psychiatry
Place of Presentation
Kyoto, Japan
Related Report
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[Presentation] Association study of phencyclidine-responsive synpse-associated protein 97(SAP) gene in schizophrenia.2012
Author(s)
Yamamoto N, Uezato A, Sato-Kimura J, Haramo E, Uezato A, Jitoku D, Umino M, Umino A, Kurumaji A, Iijima Y, Kunugi H, Nishikawa T
Organizer
XXVIII CINP World Congress
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] Pharmacological characterization and exploration of novel transcripts of a developmentally regulated and phencyclidine-inducible gene, SAP97, in mammalian brains.2012
Author(s)
Haramo E, Yamamoto N, Uezato A, Hiraoka S, Hiraaki E, Umino M, Umino A, Kurumaji A, Nishikawa T
Organizer
XXVIII CINP World Congress
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] Genetic association study of synapse-associated protein 97 (SAP97) and schizophrenia.2011
Author(s)
Yamamoto N, Sato-Kimura J, Shimazu D, Uezato A, Jitoku D, Umino M, Umino A, Kurumaji A, Iijima Y, Kunugi H, Iwayama Y, Yoshikawa T, Nishikawa T.
Organizer
第54回 日本神経化学会大会
Place of Presentation
石川県加賀市
Related Report
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