Effect of antipsychotics on metabolic and cardiac side effects in Japanese patients with schizophrenia
| Project/Area Number |
23591670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
SUZUKI Yutaro 新潟大学, 医歯学総合病院, 講師 (60377158)
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| Co-Investigator(Kenkyū-buntansha) |
SOMEYA Toshiyuki 新潟大学, 医歯学系, 教授 (50187902)
FUKUI Naoki 新潟大学, 医歯学系, 助教 (90535163)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | antipsychotics / metabolic side effect / adipokine / genetic polymorphism / obesity / schizophrenia / 抗精神病薬 / 副作用 / 糖尿病 / 肥満 / アディポカイン / 糖脂質代謝異常 / 遺伝子多型 / 副作用予防 |
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| Outline of Final Research Achievements |
The side effects arising from treatment with antipsychotic drugs, such as obesity and glycolipid metabolism disorder are major side effects that affect the vital prognosis in schizophrenia patients, but their pathology and prevention methods remain unknown. The present research clarifies the following matters, contributing to the prevention of the serious side effects of antipsychotic drugs: (1) There are differences in the frequency at which such risks occur during the administration of antipsychotic drugs; (2) It is possible to predict obesity and glycolipid metabolism disorder from the blood adipokine concentration and genetic polymorphism.
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Report
(5 results)
Research Products
(46 results)
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[Presentation] 統合失調症患者の身体モニタリング-これまでの報告と今できること-2014
Author(s)
菅原典夫, 古郡規雄, 山崎學, 下田和孝, 森隆夫, 尾関祐二, 南良武, 岡本呉賦, 寒河江豊明, 松田ひろし, 須貝拓朗, 鈴木雄太郎, 染矢俊幸
Organizer
第24回日本臨床精神神経薬理学会
Place of Presentation
名古屋国際会議場（名古屋）
Year and Date
2014-11-20
Related Report
Invited
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[Presentation] 抗精神病薬治療と身体リスクに関する合同プロジェクト委員会: 抗精神病薬と糖･脂質代謝異常.
Author(s)
○須貝拓朗, 鈴木雄太郎, 山崎學, 森隆夫, 下田和孝, 古郡規雄, 菅原典夫, 福井直樹, 渡邉純蔵, 小野信, 常山暢人, 斎藤摩美, 染矢俊幸
Organizer
第34回日本臨床薬理学会
Place of Presentation
東京
Related Report
Invited
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