| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Substance dependence shows certain personality or behavioral characteristics, besides compulsiveness to drugs. Therefore, patients need effective medication in addition to psychotherapy to the psychosocial aspects of addiction. We therefore attempted to clarify NrCAM-related neural molecule network to contribute to the development of new therapeutics, because there is a few effective drugs used in present clinics. Result from the gene expression analysis using Nrcam knock-out mice treated with/without methamphetamine indicated several candidate genes involved in methamphetamine abuse. They included glutamatergic, GABAergic molecules and also stress-related molecules, which may be new therapeutic targets for addiction and its related personality behaviors.
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