Possible antipsychotic effects of minocycline in patients with schizophrenia

• Project/Area Number: 23591673
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Shimane University
• Principal Investigator: MIYAOKA Tsuyoshi 島根大学, 医学部, 准教授 (50284047)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 統合失調症 / 神経炎症 / 難治性 / ミノサイクリン / モデル動物

Research Abstract

We concluded that the Gunn rat, which exhibits a high concentration of unconjugated bilirubin, may be useful as an animal model of schizophrenia. On the other hand, there have been numerous reports that minocycline is effective in treating schizophrenia.

Research Products

• [Journal Article] Efficacy and safety of yokukansan in treatment-resistant schizophrenia : a randomized,double-blind,placebo-controlled trial(a Positive and Negative Syndrome Scale, five-faotor analisis) (2014)
  • Author(s): Miyaoka T, Furuya M, Horiguchi J, Wake R, Hashioka S, Tohyama M, Mori N, Minabe Y, Iyo M, Ueno S, Ezoe S, Murotani K, Hoshino S, Seno H
  • Journal Title: Psychopharmacology(Berl) Volume: (in press)
• [Journal Article] The Effects of combine treatment of memantine and donepezil on Alzheimer's Disease patients and its relationship with cerebral blood flow in the prefrontal area (2014)
  • Author(s): Araki T, Wake R, Miyaoka T, Kawakami K, Nagahama M, Furuya M, Limoa E, Liaury K, Hashioka S, Murotani K, Horiguchi J
  • Journal Title: Int J Geriatr Psychiatry Volume: (in press)
• [Journal Article] The Effects of Aging on Changes in Regional Cerebral Blood Flow in Schizophrenia (2014)
  • Author(s): Kawakami K, Wake R, Miyaoka T, Furuya M, Liaury K, Horiguchi J
  • Journal Title: Neuropsychobiology Volume: 69(4) Pages: 202-209
  • Peer Reviewed
• [Journal Article] Minocycline improves recognition memory and attenuates microglial activation in Gunn rat : a possible hyperbilirubinemia-induced model of schizophrenia (2014)
  • Author(s): Liaury K, Miyaoka T, Tsumori T, Furuya M, Hashioka S, Wake R, Tsuchie K, Fukushima M, Limoa E, Tanra AJ, Horiguchi J
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 50 Pages: 184-190
  • Peer Reviewed
• [Journal Article] The effects of combine treatment of memantine and donepezil on Alzheimer’s Disease patients and its relationship with cerebral blood flow in the prefrontal area. (2014)
  • Author(s): Araki T, Wake R, Miyaoka T, Kawakami K, Nagahama M, Furuya M, Limoa E, Liaury K, Hashioka S, Murotani K, Horiguchi J
  • Journal Title: Int J Geriatr Psychiatry Volume: 10 Pages: 4074-4074
  • Peer Reviewed
• [Journal Article] Minocycline improves recognition memory and attenuates microglial activation in Gunn rat:a possible hyperbilirubilirubinemia-induced animal model of schizophrenia. (2014)
  • Author(s): Liaury K, Miyaoka T, Tsumori T, Furuya M, Hashioka S, Wake R, Tsuchie K, Fukushima M, Limoa E, Tanra AJ, Horiguchi J
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 50 Pages: 184-190
  • Peer Reviewed
• [Journal Article] Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat (2013)
  • Author(s): Furuya M, Miyaoka T, Tsumori T, Liaury K, Hashioka S, Wake R, Tsuchie K, Fukushima M, Ezoe S and Horiguchi J
  • Journal Title: JOURNAL OF NEUROINFLAMMATION Volume: 10 Pages: 145-145
  • Peer Reviewed
• [Journal Article] Yokukansan (TJ-54) forIrritability Associated with Pervasive Developmental Disorder in Children and Adolescents : A 12-Week Prospective, Open-Label Study (2013)
  • Author(s): Wake R, MD, Miyaoka T, Inagaki T, MD, Furuya M, Ieda M, MD, Liaury K, MD, Kishi K, Horiguchi J
  • Journal Title: JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY Volume: 23(5) Pages: 329-336
  • Peer Reviewed
• [Journal Article] Evaluation of autonomic nervous system by salivary alpha-amylase level and heart rate variability in patients with schizophrenia (2013)
  • Author(s): Ieda M, Miyaoka T, Wake R, Liaury K, Tsuchie K, Fukushima M, Araki T, Ezoe S, Inagaki T, Horiguchi J
  • Journal Title: Eur Arch Psychiatry Clin Neurosci
  • Peer Reviewed
• [Journal Article] Glia : An Important Target for Anti-Inflammatory and Antidepressant Activity (2013)
  • Author(s): Hashioka S, Miyaoka T, Wake R, Furuya M and Horiguchi J
  • Journal Title: Current Drug Targets Volume: 14(11) Pages: 1322-1328
  • NAID: 120006863742
  • Peer Reviewed
• [Journal Article] Yokukansan(TJ-54) for treatment of very-late-onset schizophrenia-like psychosis : An open-label study (2013)
  • Author(s): Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S, Horiguchi J
  • Journal Title: Phytomedicine Volume: 20(7) Pages: 654-658
  • Peer Reviewed
• [Journal Article] The effects of antipsychotics on behavioral abnormalities of the Gunn rat (unconjugated hyperbilirubinemia rat), a rat model of schizophrenia (2013)
  • Author(s): Tsuchie K, Miyaoka T, Furuya M, Liaury K, Ieda M, Wake R, Horiguchi J, Takechi M
  • Journal Title: Asian Journal of Psychiatry Volume: 6(2) Pages: 119-123
  • Peer Reviewed
• [Journal Article] Possibility of early withdrawal of benzodiazepine hypnotics by combination with ramelteon for the treatment of insomnia : A pilot study (2013)
  • Author(s): Furuya M, Miyaoka T, Wake R, Nagahama M, Kawano K, Yamashita S, Ieda M, Ezoe S and Horiguchi J
  • Journal Title: Sleep and Biological Rhythms Volume: 11(1) Pages: 55-61
  • Peer Reviewed
• [Journal Article] Yokukansan prometes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat. (2013)
  • Author(s): Furuya M, Miyaoka T, Tsumori T, Liaury K, Hashioka S, Wake R, Tsuchie K, Fukushima M, Ezoe S, Horiguchi J
  • Journal Title: J Neuroinflammation Volume: 10 Pages: 145-145
  • Peer Reviewed
• [Journal Article] Possibility of early withdrawal of benzodiazepine hypnotics by combination with ramelteon for the treatment of insomnia: A pilot study. (2013)
  • Author(s): Furuya M, Miyaoka T, Wake R, Nagahama M, Kawano K, Yamashita S, Ieda M, Ezoe S and Horiguchi J
  • Journal Title: Sleep and Biological Rhythms Volume: 11（1） Pages: 55-61
  • Peer Reviewed
• [Journal Article] Yokukansan(TJ-54)for treatment of very-late-onset schizophrenia-like psychosis: An open-label study. (2013)
  • Author(s): Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S, Horiguchi J
  • Journal Title: Phytomedicine Volume: 20(7) Pages: 654-658
  • Peer Reviewed
• [Journal Article] Glia: An Important Target for Anti-Inflammatory and Antidepressant Activity. (2013)
  • Author(s): Hashioka S, Miyaoka T, Wake R, Furuya M and Horiguchi J
  • Journal Title: Current Drug Targets Volume: 14(11) Pages: 1322-1328
  • NAID: 120006863742
  • Peer Reviewed
• [Journal Article] Yokukansan(TJ-54) for Irritability Associated with Pervasive Developmental Disorder in Children and Adolescents: A 12-Week Prospective,Open-Label Study. (2013)
  • Author(s): Wake R, Miyaoka T, Inagaki T, Furuya M, Ieda M, Liaury K, Kishi K and Horiguchi J
  • Journal Title: JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY Volume: 23(5) Pages: 329-336
  • Peer Reviewed
• [Journal Article] Yokukansan (TJ-54) for treatment of pervasive developmental disorder not otherwise specified and Asperger's disorder : a 12-week prospective, open-label stury (2012)
  • Author(s): Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Inagaki T and Horiguchi J
  • Journal Title: BMC Psychiatry Volume: 12 Pages: 215-215
  • Peer Reviewed
• [Journal Article] Minocycline for Schizophrenia : A critical review (2012)
  • Author(s): Miyaoka T
  • Journal Title: Open Journal of Psychiatry Volume: 2 Pages: 399-406
  • Peer Reviewed
• [Journal Article] Yokukansan(TJ-54)for treatment of very-late-onset Schizophrenia-like psychosis.An open-Label Study Authors. (2012)
  • Author(s): Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S, Horiguchi J
  • Journal Title: Phytomedicine Volume: 20(7) Pages: 654-8
  • Peer Reviewed
• [Journal Article] Yokukansan(TJ-54)for Treatment of Pervasive Developmental Disorder Not Otherwise Specified and Asperger’s Disorder. (2012)
  • Author(s): Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Inagaki T and Horiguchi J
  • Journal Title: BMC Psychiatry Volume: 12(1) Pages: 215-215
  • Peer Reviewed
• [Journal Article] Minocycline as adjunctive therapy for patients with unipolar psychoatic depression: An open-label study (2012)
  • Author(s): Tsuyoshi Miyaoka et al.
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry Volume: 37 Pages: 222-226
  • Peer Reviewed
• [Journal Article] Morphological features of microglial cells in the hippocampal dentate gyrus of Gunn rat: a possible schizophrenia animal model (2012)
  • Author(s): Kristian Liaury, Tsyuyoshi Miyaoka
  • Journal Title: Journal of Neuroinflammation Volume: 9 Issue: 1 Pages: 56-56
  • DOI: 10.1186/1742-2094-9-56
  • Peer Reviewed
• [Presentation] Efficacy and safety of yokukansan (TJ-54) for treatment-resistant schizophrenia : a randomised placebo-controlled trial (2013)
  • Author(s): Miyaoka T, Furuya M, Horiguchi J, Wake R, Hayashida S, Toyama M, Daimon T, Mori N, Minabe Y, Iyo M
  • Organizer: 26th ECNP
  • Place of Presentation: Barcelona, Spain
• [Presentation] Comorbidity between Neuroinflammatory Disorders and Depression (2013)
  • Author(s): Miyaoka T
  • Organizer: The 4th World Congress of Asian Psychiatry
  • Place of Presentation: Bangkok, Thailand
• [Presentation] The correlation between psychiatric symptoms and regional cerebral blood flow in first episode schizophrenia patients (2013)
  • Author(s): Wake R, Miyaoka T, Kawakami K, Furuya M, Liaury K, Hashioka S, Horiguchi J
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] The correlation between psychiatric symptoms and regional cerebral blood flow in first episode schizophrenia patients (2013)
  • Author(s): Wake R, Miyaoka T, Kawakami K, Furuya M, Liaury K, Hashioka S, Horiguchi J
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: (Kyoto) Japan
• [Presentation] Anti-inflammatory treatments of unipolar depression and bipolar desorder (2013)
  • Author(s): Miyaoka T
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Comorbidity of depression with neuro-inflammatory disorders (2013)
  • Author(s): Miyaoka T
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] The Effects of Minocycline on Microglial Cells in The Dentate Gyrus of Gunn Rat―A Possible Animal Model of Schizophrenia― (2013)
  • Author(s): Liaury K, Miyaoka T, Tsumori T, Wake R, Furuya M, Ieda M, Tsuchie K, Fukushima M, A J Tanra, Horiguchi J
  • Organizer: 第28回日本老年精神医学会
  • Place of Presentation: 大阪
• [Presentation] Efficacy and Safety of Yokukansan (TJ-54) for Treatment-Resistant Schizophrenia : A Randomized, Multi-centre, Double-blind, Placebo-controlled Trial (2013)
  • Author(s): Miyaoka T, Furuya M, Horiguchi J, Wake R, Hashioka J, Toyama M, Daimon T, Mori N, Minabe Y, Iyo M, Ueno S, Ezoe S, Hoshino S, Seno H
  • Organizer: Society of Biological Psychiatry 68th Annual Meeting
  • Place of Presentation: (San Francisco) California
• [Presentation] Yokukansan (TJ-54) for Irritability Associated with Pervasive Developmental Disorder in Children and Adolescents A 12-week Prospective, Open-label Study (2013)
  • Author(s): Wake R, Miyaoka T, Inagaki T, Furuya M, Ieda M, Liaury K, Kishi K, Horiguchi J
  • Organizer: The 7th Annual Scientific Meeting Hong Kong Society of Biological Psychiatry
  • Place of Presentation: Hong Kong
• [Presentation] Yokukansan (TJ-54)For Treatment Of Very-Late-Onset Schizophrenia-Like Psychosis : An Open-Label Study (2013)
  • Author(s): Miyaoka T
  • Organizer: The 3rd ASIAN CONGRESS ON SCHIZOPHRENIA RESEARCH(ACSR2013)
  • Place of Presentation: Sanur, Bali, Indonesia
• [Presentation] Yokukansan Promote Hippocampal Neurogenesis Through The Inhibition of Microglial Activation in Rodents with Hyperbillirubinemia : a neuroinflammational animal model of schizophrenia (2013)
  • Author(s): Furuya M, Miyaoka T, Tsumori T, Hashioka S, Wake R, Liaury K, Ieda M, Ishihara K, Tsuchie K, Fukushima M, Araki T, Ezoe S, Horiguchi J
  • Organizer: The 3rd ASIAN CONGRESS ON SCHIZOPHRENIA RESEARCH(ACSR2013)
  • Place of Presentation: Sanur, Bali, Indonesia
• [Presentation] Yokukansan(TJ-54)for Irritability Associated with Pervasive Developmental Disorder in Children and Adolescents A 12-week Prospective, Open-Label Study. (2013)
  • Author(s): Wake R, Miyaoka T, Inagaki T, Furuya M, Ieda M, Liaury K, Kishi K, Horiguchi J
  • Organizer: The 7th Annual Scientific Meeting Hong Kong Society of Biological Psychiatry.
  • Place of Presentation: (Hong Kong) Eaton
  • Invited
• [Presentation] Efficacy and Safety of Yokukansan(TJ-54) for Treatment-Resistant Schizoohrenia: A Randmized,Multi-centre, Double-blind, Placebo-controlledTrial. (2013)
  • Author(s): Miyaoka T, Furuya M, Horiguchi J, Wake R, Hashioka S, Toyama M, Daimon T, Mori N, Minabe Y, Iyo M, Ueno S, Ezoe S, Hoshino S, Seno H
  • Organizer: Society of Biological Osychiatry 68th Annual Meeting
  • Place of Presentation: (San Francisco California) Hilton Union Square
• [Presentation] Comorbidity between Neuroinflammatory Disorders and Depression. (2013)
  • Author(s): Miyaoka T
  • Organizer: The 4th World Conressof Asian Psychiatry
  • Place of Presentation: (Bangkok Thailand) Centara Grand at Central Worid
  • Invited
• [Presentation] Efficacy and safety of yokukansan(TJ-54) for treatment-resistant schizophrenia:a randmised placebo-controlled trial. (2013)
  • Author(s): Miyaoka T, Furuya M, Horiguchi J, Wake R, Hayashida M, Toyama M, Daimon T, Mori N, Minabe Y, Iyo M
  • Organizer: 26th ECNP
  • Place of Presentation: (Barcelona Spain) Catalunya Paul
• [Presentation] Yokukansan(TJ-54)for treatment of very-late onset shizophrenia-like psychosis:an open-label study. (2012)
  • Author(s): Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S, Horiguchi J
  • Organizer: 12th Annual Meeting of the International College of Geriatric Psychoneuropharmacology
  • Place of Presentation: Spain(Sevilia)