Study on the improvement of neural network disruption in depression.

• Project/Area Number: 23591677
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401)
• Co-Investigator(Kenkyū-buntansha): UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256) ; YAMADA Misa 独立行政法人国立精神・神経研究センター, 精神保健研究所, 研究員 (10384182)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経科学 / 脳・神経 / うつ病 / 抗うつ薬 / 神経新生 / 神経幹細胞 / BDNF / 末梢血

Research Abstract

We evaluated the effective treatment way of cellular biodistribution of stem cells and BDNF into the brain after intravenous injection. We analyzed the influence of antidepressants on platelet BDNF release and found that BDNF release from platelets may be useful for screening the most suitable antidepressant by predicting an individual response to antidepressant treatment. We also investigated the expression of rhotekin and Prg1 in adult rat brain and found that they may play important roles in neurogenesis.

Research Products

• [Journal Article] Stem cell therapy, a new approach to the treatment of refractory depression. (2014)
  • Author(s): Kigawa Y, Hashimoto E, Ukai W, Ishii T, Furuse K, Tsujino H, Shirasaka T, Saito T.
  • Journal Title: J Neural Transm Volume: 130 Issue: 10 Pages: 1221-1232
  • DOI: 10.1007/s00702-014-1194-2
  • Peer Reviewed / Open Access
• [Journal Article] Plasticity-related gene 1 is important for survival of neurons derived from rat neural stem cells. (2013)
  • Author(s): Hashimoto T, Yamada M, Imai T, Saitoh A, Hashimoto E, Ukai W, Saito T, Yamada M.
  • Journal Title: J Neurosci Res Volume: 91 Issue: 11 Pages: 1402-1407
  • DOI: 10.1002/jnr.23269
  • Peer Reviewed
• [Journal Article] Effects of atelocollagen on neural stem cell function and its migrating capacity into brain in psychiatric disease model. (2013)
  • Author(s): Yoshinaga T, Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa M, Tateno M, Kaneta H, Watanabe K, Igarashi T, Kobayashi S, Sohma H, Kato T, Saito T.
  • Journal Title: J Neural Transm Volume: 120 Issue: 10 Pages: 1491-1498
  • DOI: 10.1007/s00702-013-1010-4
  • Peer Reviewed
• [Journal Article] アルコール性気分障害の臨床 (2013)
  • Author(s): 石井貴男, 橋本恵理, 齋藤利和.
  • Journal Title: 臨床精神医学 Volume: 42 Pages: 1027-1034
• [Journal Article] Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene (2013)
  • Author(s): Nishioka Masaki
  • Journal Title: International Journal of Developmental Neuroscience Volume: 31 Issue: 2 Pages: 89-95
  • DOI: 10.1016/j.ijdevneu.2012.11.007
  • Peer Reviewed
• [Journal Article] Rhotekin modulates differentiation of cultured neural stem cells to neurons (2012)
  • Author(s): Iwai T, Saitoh A, Yamada M, Takahashi K, Hashimoto E, Ukai W, Saito T, Yamada M
  • Journal Title: J Neurosci Res Volume: 90(7) Issue: 7 Pages: 1359-66
  • DOI: 10.1002/jnr.23029
  • Peer Reviewed
• [Journal Article] Antipsychotic induced alteration of growth and proteome of rat neural stem cells. (2012)
  • Author(s): Ahmed EU, Ahmed S, Ukai W, Matsumoto I, Kemp A, McGregor IS, Kashem MA.
  • Journal Title: Neurochem Res Volume: 37 Issue: 8 Pages: 1649-1659
  • DOI: 10.1007/s11064-012-0768-3
  • Peer Reviewed
• [Journal Article] Stem cell therapy: social recognition recovery in a FASD model. (2012)
  • Author(s): Shirasaka T, Hashimoto E, Ukai W, Yoshinaga T, Ishii T, Tateno M, Saito T.
  • Journal Title: Transl Psychiatry Volume: 2 Issue: 11 Pages: 1-9
  • DOI: 10.1038/tp.2012.111
  • Peer Reviewed
• [Journal Article] 生物学的研究から新たな治療戦略へ アルコール・薬物依存に対する再生医療的アプローチ. (2012)
  • Author(s): 橋本恵理
  • Journal Title: 日本アルコール関連問題学会雑誌 Volume: 14 Pages: 39-41
• [Journal Article] 統合失調症の脳神経回路修復－薬物・細胞コンバインド療法の可能性の検討. (2012)
  • Author(s): 鵜飼渉, 小野貴文, 橋本恵理, 金田博雄, 白坂知彦, 五十嵐健史, 木川昌康, 渡邊公彦, 吉永敏弘, 石井貴男, 館農勝, 小林清樹, 齋藤利和.
  • Journal Title: 日本生物学的精神医学会誌 Volume: 23 Pages: 109-114
  • NAID: 130005395398
• [Journal Article] Heat stress activates ER stress signal which suppress the heat shock response, an effect occurring preferentially in the cortex in rats. (2012)
  • Author(s): Liu Y, et al.
  • Journal Title: Mol Biol Rep Volume: 39 Pages: 3987-3993
  • Peer Reviewed
• [Journal Article] Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons (2011)
  • Author(s): Iwamoto K, Ukai W, Hashimoto E, et al
  • Journal Title: Genome Res Volume: 21(5) Issue: 5 Pages: 688-696
  • DOI: 10.1101/gr.112755.110
  • Peer Reviewed
• [Journal Article] FASDモデルに対する神経幹細胞移植療法の可能性－神経回路網再生と行動学的変化の解析. (2011)
  • Author(s): 白坂知彦, 他.
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 46 Pages: 576-584
  • Peer Reviewed
• [Journal Article] 双極性障害と物質使用障害. (2011)
  • Author(s): 橋本恵理, 他.
  • Journal Title: 臨床精神医学 Volume: 40 Pages: 907-913
• [Journal Article] 気分障害. (2011)
  • Author(s): 鵜飼渉, 他.
  • Journal Title: 精神科 Volume: 18 Pages: 618-623
• [Presentation] Effects of ethanol and antidepressant on the platelet BDNF release function in the peripheral blood : Implication in the pathogeness of psychiatric disease. (2013)
  • Author(s): Saito T, Hashimoto E, Ukai W, Ishii T, Kigawa Y, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T.
  • Organizer: 52^<nd> Annual Meeting of the American College of Neuropsychopharmacology
  • Place of Presentation: Florida, U.S.A.
• [Presentation] Alteration of platelet BDNF release function in the peripheral blood. (2013)
  • Author(s): Saito T, Hashimoto E, Ukai W, Ishii T, Kigawa Y, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T.
  • Organizer: The 3^<rd> Congress of Asian Colloge of Neuropsychopharmacology
  • Place of Presentation: Beijing, China.
• [Presentation] Basic aspects of alcohol use disorder comorbid with depressive disorder. (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Kigawa Y, Yoshinaga T, Watanabe K, Shirasaka T, Tateno M, Kobayashi S, Saito T.
  • Organizer: [Symposium] Alcohol abuse comorbidity. 14^<th> Congress of ESBRA
  • Place of Presentation: Warsaw, Poland.
• [Presentation] Usage of peripheral-derived cytokine as a marker and treatment approach for neural plasticity change in alcohol-induced brain damage and depression. (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Watanabe K, Shirasaka T, Kaneta H, Kigawa Y, Yoshinaga T, Tateno M, Saito T.
  • Organizer: [Symposium] Trans- lational perspective on the imaging, epigenetics and peripheral-derived markers for alcohol induced brain damage and depression. 11^<th> World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Usage of peripheral-derived cytokine as a marker and treatment approach for neural plasticity change in alcohol-induced brain damage and depression. (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Watanabe K, Shirasaka T, Kaneta H, Kigawa Y, Yoshinaga T, Tateno M, Saito T.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto, Japan
• [Presentation] 抗うつ薬関連遺伝子Prg1は神経細胞の生存維持に重要な因子である (2013)
  • Author(s): 橋本富男, 山田美佐, 岩井孝志, 斎藤顕宜, 橋本恵理, 鵜飼渉, 齋藤利和
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Basic aspects of alcohol use disorder comorbid with depressive disorder. (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Kigawa Y, Yoshinaga T, Watanabe K, Shirasaka T, Tateno M, Kobayashi S, Saito T.
  • Organizer: 14th Congress of ESBRA
  • Place of Presentation: Warsaw, Poland
  • Invited
• [Presentation] Understanding of mechanism underlyng brain abnormality in FASD and its translational approach. (2013)
  • Author(s): Ukai W, Hashimoto E, Ishii T, Kigawa Y, Furuse K, Tsujino H, Shirasaka T, Yoshinaga T, Tateno M, Saito T.
  • Organizer: 14th Congress of ESBRA
  • Place of Presentation: Warsaw, Poland
• [Presentation] Stem cell research on alcoholism (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa Y, Yoshinaga T, Tateno M, Furuse K, Imai T, Saito T.
  • Organizer: CINP Special Congress on Addiction and Mental Health
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Alteration of platelet BDNF release function in the peripheral blood. (2013)
  • Author(s): Saito T, Hashimoto E, Ukai W, Ishii T, Kigawa Y, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T.
  • Organizer: The 3rd Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Beijing, China
• [Presentation] DNA methylation analysis of human neuronal and non-neuronal cells at the base pair resolution. (2013)
  • Author(s): Ueda J, Bundo M, Sunaga F, Nishioka M, Hashimoto E, Ukai W, Saito T, Kasai K, Iwamoto K, Kato T.
  • Organizer: American Society of Human Genetics 2013 Annual Meeting
  • Place of Presentation: Boston, U.S.A.
• [Presentation] 精神疾患に対する再生医療アプローチの可能性 (2013)
  • Author(s): 鵜飼渉, 橋本恵理, 石井貴男, 木川昌康, 古瀬研吾, 辻野華子, 白坂知彦, 吉永敏弘, 小林清樹, 齋藤利和
  • Organizer: 第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会 合同年会
  • Place of Presentation: 沖縄
• [Presentation] Alcohol reduces the effect of antidepressants on platelet BDNF release. (2013)
  • Author(s): Ishii T, Ukai W, Kigawa Y, Furuse K, Kakutani Y, Hashimoto E, Saito T.
  • Organizer: The 43rd Annual Meeting of the Society of Neuroscience
  • Place of Presentation: San Diego, U.S.A.
• [Presentation] 薬物療法と神経新生・神経回路修復 (2013)
  • Author(s): 鵜飼渉, 橋本恵理, 石井貴男, 木川昌康, 古瀬研吾, 辻野華子, 吉永敏弘, 齋藤利和
  • Organizer: 第26回総合病院精神医学会総会
  • Place of Presentation: 京都
• [Presentation] Effects of ethanol and antidepressant on the platelet BDNF release function in the peripheral blood: Implication in the pathogenesis of psychiatric disease. (2013)
  • Author(s): Saito T, Hashimoto E, Ukai W, Ishii T, Kigawa Y, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T.
  • Organizer: 52nd Annual Meeting of the American College of Neuropsychopharmacology
  • Place of Presentation: Florida, U.S.A.
• [Presentation] intravenous therapy for psychiatric diseases : regeneration of damaged neural network by ethanol and depression. (2012)
  • Author(s): Ukai W, Hashimoto E, Shirasaka T, Kaneta H, Igarashi T, Kigawa M, Watanabe K, Yoshinaga T, Tateno M, Ishii T, Saito T.
  • Organizer: 35^<th> Annual Scientific Meeting for Research on Alcoholism
  • Place of Presentation: San Francisco, U.S.A.
• [Presentation] The effect of antipsychotics on GABAergic interneurongenesis in adult brain. (2012)
  • Author(s): Ukai W, Kaneta H, Hashimoto E, Igarashi T, Shirasaka T, Kigawa M, Watanabe K, Yoshinaga T, Tateno M, Ishii I, Saito T.
  • Organizer: 28th CINP Congress
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Peripheral intravenous therapy for psychiatric diseases: regeneration of damaged neural network by ethanol and depression. (2012)
  • Author(s): Ukai W, Hashimoto E, Shirasaka T, Kaneta H, Igarashi T, Kigawa M, Watanabe K, Yoshinaga T, Tateno M, Ishii T, Saito T.
  • Organizer: 35th Annual Scientific Meeting for Research on Alcoholism
  • Place of Presentation: San Francisco, U.S.A.
• [Presentation] Promising therapy of neural stem cell transplantation for FASD model - a new strategy for neural network reconstruction and behavioral recovery - (2012)
  • Author(s): Shirasaka T, Yoshinaga T, Ukai W, Tateno M, Watanabe K, Kigawa M, Kaneda H, Igarashi T, Ishikawa H, Hashimoto E, Saito T.
  • Organizer: 35th Annual Scientific Meeting for Research on Alcoholism
  • Place of Presentation: San Francisco, U.S.A.
• [Presentation] アルコールによる脳障害に対する新たな治療法の可能性を探る：FASDモデルを用いた検討. (2012)
  • Author(s): 橋本恵理, 白坂知彦, 吉永敏弘, 金田博雄, 木川昌康, 五十嵐健史, 渡邊公彦, 石井貴男, 鵜飼渉, 館農勝, 齋藤利和.
  • Organizer: 第47回日本アルコール・薬物医学会・第３４回日本アルコール関連問題学会・第21回日本依存神経精神科学会 平成24年度アルコール・薬物関連学会合同学術総会
  • Place of Presentation: 札幌
• [Presentation] Alcohol, epigenetics and brain damage. (2012)
  • Author(s): Ukai W, Shirasaka T, Hashimoto E, Kaneta H, Igarashi T, Kigawa M, Watanabe K, Yoshinaga T, Tateno M, Ishii T, Saito T.
  • Organizer: 16th Congress of ISBRA
  • Place of Presentation: Sapporo, Japan
• [Presentation] Intravenous neural stem cell transplantation - a strategy for facilitation of neural network and behavioral recovery - (2012)
  • Author(s): Shirasaka T, Ukai W, Hashimoto E, Kaneta H, Igarashi T, Kigawa M, Watanabe K, Ishii T, Yoshinaga T, Kobayashi S, Tateno M, Saito T.
  • Organizer: 16th Congress of ISBRA
  • Place of Presentation: Sapporo, Japan
• [Presentation] BDNF as a potential biomarker for fetal alcohol effects - comparative study of serum concentration in rat model. (2012)
  • Author(s): Igarashi T, Watanabe K, Ukai W, Hashimoto E, Shirasaka T, Kaneta H, Kigawa M, Ishii T, Yoshinaga T, Kobayashi S, Tateno M, Saito T.
  • Organizer: 16th Congress of ISBRA
  • Place of Presentation: Sapporo, Japan
• [Presentation] Treatment response of depressive patients with comorbid alcohol use disorders. (2012)
  • Author(s): Ishikawa H, Shirasaka T, Hashimoto E, Saito T.
  • Organizer: 16th Congress of ISBRA
  • Place of Presentation: Sapporo, Japan
• [Presentation] 抗うつ薬関連遺伝子Prg1は神経細胞の生存維持に重要な因子である (2012)
  • Author(s): 橋本富男、山田美佐、岩井孝志、斎藤顕宜、橋本恵理、鵜飼渉、齋藤利和、山田光彦
  • Organizer: 第31回躁うつ病の薬理・生化学的研究懇話会
  • Place of Presentation: 大分
• [Presentation] Ethanol-induced growth factor dysfunctions in neural stem cells: Implication to stress. (2011)
  • Author(s): Ukai W, et al.
  • Organizer: The 2nd International Congress on Alcoholism and Stress: a Framework for Future Treatment and Strategies
  • Place of Presentation: Volterra, Italy
• [Presentation] Potential regulation of neurogenesis by antidepressant/stem cell transplantation in alcohol-induced brain damage. (2011)
  • Author(s): Hashimoto E, et al.
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Stem cell therapy: Social function recovery in fetal alcohol spectrum disorder model. (2011)
  • Author(s): Ukai W, et al.
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] The migration of peripheral brain-derived neurotrophic factor (BDNF) to the hippocampus in rats. (2011)
  • Author(s): Watanabe K, et al.
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Biological markers in psychiatric disorders: Alcoholism/Depression (2011)
  • Author(s): Saito T, et al.
  • Organizer: 10th World Congress of Biological Psychiatry(招待講演)
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Stem cell therapy: A novel treatment strategy for fetal alcohol spectrum disorder. (2011)
  • Author(s): Saito T, et al.
  • Organizer: The 34th annual scientific meeting of the Research Society on Alcoholism
  • Place of Presentation: Atlanta, U.S.A.
• [Presentation] Promotion of interneurogenesis by neural stem cell transplantation in FASD model. (2011)
  • Author(s): Ukai W, et al.
  • Organizer: 13th Congress of European Society for Biomedical Research on Alcoholism
  • Place of Presentation: Vienna, Austria
• [Presentation] The possible therapeutic approach for amelioration of alcohol-induced brain damage. (2011)
  • Author(s): Hashimoto E, et al.
  • Organizer: 13th Congress of European Society for Biomedical Research on Alcoholism
  • Place of Presentation: Vienna, Austria
• [Presentation] Neurogenesis of alcohol related problems and depresssion. (2011)
  • Author(s): Saito T, et al.
  • Organizer: 2nd Congress of Asian College of Neurospychopharmacology(招待講演)
  • Place of Presentation: Seoul, South Korea
• [Presentation] Serum BDNF as a potential biomarker for fetal alcohol effects. (2011)
  • Author(s): Watanabe K, et al.
  • Organizer: 2nd Congress of Asian College of Neurospychopharmacology
  • Place of Presentation: Seoul, South Korea
• [Presentation] Rhotekinは培養神経幹細胞の神経分化過程を調節する. (2011)
  • Author(s): 岩井孝志, 他
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京, 日本
• [Presentation] 抗うつ効果が期待できる新たな薬剤の検索. (2011)
  • Author(s): 橋本恵理, 他
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京, 日本
• [Presentation] Antidepressant-induce platelet BDNF release: implication to the neurogenesis dysfunction in depression. (2011)
  • Author(s): Ukai W, et al
  • Organizer: The 41st annual meeting of the Society of Neuroscience
  • Place of Presentation: Washington, D.C., U.S.A.
• [Presentation] The effect of antipsychotics in interneurogenesis of adult neural stem cells. (2011)
  • Author(s): Kaneta H, et al.
  • Organizer: The 41st annual meeting of the Society of Neuroscience
  • Place of Presentation: Washington, D.C., U.S.A.
• [Book] メンタル医療－原因解明と診断, 治療の最前線－ (2013)
  • Author(s): 鵜飼渉, 石井貴男, 橋本恵理.
  • Publisher: シーエムシー出版
• [Book] 気分障害の薬理・生化学～うつ病の脳内メカニズム研究 : 進歩と挑戦～ (2012)
  • Author(s): 橋本恵理
  • Publisher: 医薬ジャーナル社
• [Book] 気分障害の薬理・生化学～うつ病の脳内メカニズム研究：進歩と挑戦～ (2012)
  • Author(s): 橋本恵理
  • Publisher: 医薬ジャーナル社
• [Book] 精神医学キーワード辞典 (2011)
  • Author(s): 橋本恵理
  • Publisher: 中山書店