Stem cell therapy for psychiatric disorders using granulocyte-colony stimulating factor
Project/Area Number |
23591678
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401)
UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256)
TATENO Masaru 札幌医科大学, 医学部, 講師 (60464492)
安宅 弘司 札幌医科大学, 医学部, 助教 (30563358)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 精神薬理学 / 顆粒球コロニー刺激因子 / 細胞治療 / 再生医療 / 神経幹細胞 / 神経新生 / 造血幹細胞移植 / G-CSF / 造血幹細胞 / 胎児性アルコールスペクトラム障害 / 骨髄移植 / 精神薬理 / 胎児性アルコールスペクトラム症候群 |
Research Abstract |
The purpose of this study is to develop a possible therapeutic approach for psychiatric disorders by neurogenesis upregulation through increase of peripheral hematopoietic stem cells. First, we have demonstrated that the combined peripheral treatment of stem cells and antidepressant, which has been indicated to increase trophic factors in the serum could have potential to recover the abnormal behavior of treatment-resistant refractory depression model. We have also shown that peripherally treated neural stem cells concentrated much in the hypothalamus areas where oxytocin/vasopresinergic neurons exist, and recovered social/cognitive impairment of psychiatric disease model including parental behavior.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Effects of atelocollagen on neural stem cell function and its migrating capacity into brain in psychiatric disease model.2013
Author(s)
Yoshinaga T, Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa M, Tateno M, Kaneta H, Watanabe K, Igarashi T, Kobayashi S, Sohma H, Kato T, Saito T.
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Journal Title
J Neural Transm
Volume: 120
Issue: 10
Pages: 1491-1498
DOI
Related Report
Peer Reviewed
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[Journal Article] 統合失調症の脳神経回路修復薬物・細胞コンバインド療法の可能性の検討2012
Author(s)
鵜飼渉,小野貴文,橋本恵理,金田博雄,白坂知彦,五十嵐健史,木川昌康,渡邊公彦,吉永敏弘,石井貴男,館農勝,小林清樹,齋藤利和
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Journal Title
日本生物学的精神医学会誌
Volume: 23
Pages: 109-114
NAID
Related Report
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[Journal Article] 統合失調症の脳神経回路修復 薬物・細胞コンバインド療法の可能性の検討2012
Author(s)
鵜飼 渉, 小野 貴文, 橋本 恵理, 金田 博雄, 白坂 知彦, 五十嵐 健史, 木川 昌康, 渡邊 公彦, 吉永 敏弘, 石井 貴男, 館農 勝, 小林 清樹, 齋藤 利和
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Journal Title
日本生物学的精神医学会誌
Volume: 23
Pages: 109-114
NAID
Related Report
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[Presentation] 精神疾患に対する再生医療的アプローチの可能性, 依存研究を基盤にした精神疾患の病因解明の試み2013
Author(s)
鵜飼渉,橋本恵理,石井貴男,木川昌康,古瀬健吾,辻野華子,白坂知彦,吉永敏弘,小林清樹,齋藤利和
Organizer
第23回日本臨床精神神経薬理学会
Place of Presentation
沖縄 (シンポジウム)
Related Report
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[Presentation] Usage of peripheral-derived cytokine as a marker and treatment approach for neural plasticity change in alcohol-induced brain damage and depression, Translational perspective on the imaging, epigenetics and peripheral-derived markers for alcohol induced brain damage and depression2013
Author(s)
Hashimoto E, Ukai W, Ishii T, Watanabe K, Shirasaka T, Kaneta H, Kigawa Y, Yoshinaga T, Tateno M, Saito T
Organizer
WFSBP Congress of Biological Psychiatry
Place of Presentation
Kyoto (Symposium)
Related Report
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[Presentation] アルコール脳障害の病態理解とその治療的アプローチ2013
Author(s)
鵜飼渉,橋本恵理,白坂知彦,石井貴男,吉永敏弘,金田博雄,木川昌康,館農勝,齋藤利和
Organizer
依存症発症メカニズムの脳科学.第36回日本神経科学大会第56回日本神経化学会大会第23回日本神経回路学会大会合同大会/Neuro2013
Place of Presentation
京都 (シンポジウム)
Related Report
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[Presentation] Understanding of mechanisms underlying brain abnormality in FASD and its translational approach.2013
Author(s)
Ukai W, Hashimoto E, Shirasaka T, Ishii T, Yoshinaga T, Kaneta H, Kigawa Y, Tateno M, Kobayashi S, Saito T.
Organizer
14th Congress of ESBRA
Place of Presentation
Warsaw, Poland
Related Report
Invited
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[Presentation] The effect of antipsychotics on GABAergic interneurogenesis in adult brain2012
Author(s)
Ukai W, Kaneta H, Hashimoto E, Igarashi T, Kigawa Y, Shirasaka T, Watanabe K, Yoshinaga T, Tateno M, Ishii T, Saito T
Organizer
28th Collegium Internationale Neuro-Psychopharmacologicum (CINP) Congress
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] アルコールによる脳障害に対する新たな治療法の可能性を探る-FASDモデルを用いた検討2012
Author(s)
橋本恵理, 白坂知彦, 吉永敏弘, 金田博雄, 木川昌康, 五十嵐健史, 渡邊公彦, 石井貴男, 鵜飼渉,館農勝, 齋藤利和
Organizer
アルコール・薬物依存関連学会
Place of Presentation
札幌
Related Report
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