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Stem cell therapy for psychiatric disorders using granulocyte-colony stimulating factor

Research Project

Project/Area Number 23591678
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionSapporo Medical University

Principal Investigator

YOSHINAGA TOSHIHIRO  札幌医科大学, 医学部, 研究員 (70404704)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Eri  札幌医科大学, 医学部, 准教授 (30301401)
UKAI Wataru  札幌医科大学, 医学部, 講師 (40381256)
TATENO Masaru  札幌医科大学, 医学部, 講師 (60464492)
安宅 弘司  札幌医科大学, 医学部, 助教 (30563358)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords精神薬理学 / 顆粒球コロニー刺激因子 / 細胞治療 / 再生医療 / 神経幹細胞 / 神経新生 / 造血幹細胞移植 / G-CSF / 造血幹細胞 / 胎児性アルコールスペクトラム障害 / 骨髄移植 / 精神薬理 / 胎児性アルコールスペクトラム症候群
Research Abstract

The purpose of this study is to develop a possible therapeutic approach for psychiatric disorders by neurogenesis upregulation through increase of peripheral hematopoietic stem cells. First, we have demonstrated that the combined peripheral treatment of stem cells and antidepressant, which has been indicated to increase trophic factors in the serum could have potential to recover the abnormal behavior of treatment-resistant refractory depression model. We have also shown that peripherally treated neural stem cells concentrated much in the hypothalamus areas where oxytocin/vasopresinergic neurons exist, and recovered social/cognitive impairment of psychiatric disease model including parental behavior.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (33 results)

All 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (19 results) (of which Invited: 3 results) Book (2 results)

  • [Journal Article] Stem cell therapy : a new approach to the treatment of refractory depression2014

    • Author(s)
      Kigawa Y, Hashimoto E, Ukai W, Ishii T, Furuse K, Tsujino H, Shirasaka T, Saito T
    • Journal Title

      J Neural Transm

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] アルコール性脳障害とうつ病に対するトランスレーショナルリサーチの展望-病態解明と診断の観点から-2014

    • Author(s)
      鵜飼渉
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 25 Pages: 24-26

    • Related Report
      2013 Final Research Report
  • [Journal Article] Stem cell therapy: a new approach to the treatment of refractory depression.2014

    • Author(s)
      Kigawa Y, Hashimoto E, Ukai W, Ishii T, Furuse K, Tsujino H, Shirasaka T, Saito T.
    • Journal Title

      J Neural Transm.

      Volume: Epub ahead

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasticity-related gene 1 is important for survival of neurons derived from rat neural stem cells.2013

    • Author(s)
      Hashimoto T, Yamada M, Imai T, Saitoh A, Hashimoto E, Ukai W, Saito T, Yamada M.
    • Journal Title

      J Neurosci Res

      Volume: 91 Issue: 11 Pages: 1402-1407

    • DOI

      10.1002/jnr.23269

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of atelocollagen on neural stem cell function and its migrating capacity into brain in psychiatric disease model.2013

    • Author(s)
      Yoshinaga T, Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa M, Tateno M, Kaneta H, Watanabe K, Igarashi T, Kobayashi S, Sohma H, Kato T, Saito T.
    • Journal Title

      J Neural Transm

      Volume: 120 Issue: 10 Pages: 1491-1498

    • DOI

      10.1007/s00702-013-1010-4

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stem cell therapy: social recognition recovery in a FASD model.2012

    • Author(s)
      Shirasaka T, Hashimoto E, Ukai W, Yoshinaga T, Ishii T, Tateno M, Saito T.
    • Journal Title

      Transl Psychiatry

      Volume: 2 Issue: 11 Pages: 1-9

    • DOI

      10.1038/tp.2012.111

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antipsychotic induced alteration of growth and proteome of rat neural stem cells.2012

    • Author(s)
      Ahmed EU, Ahmed S, Ukai W, Matsumoto I, Kemp A, McGregor IS, Kashem MA.
    • Journal Title

      Neurochem Res

      Volume: 37 Issue: 8 Pages: 1649-1659

    • DOI

      10.1007/s11064-012-0768-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の脳神経回路修復薬物・細胞コンバインド療法の可能性の検討2012

    • Author(s)
      鵜飼渉,小野貴文,橋本恵理,金田博雄,白坂知彦,五十嵐健史,木川昌康,渡邊公彦,吉永敏弘,石井貴男,館農勝,小林清樹,齋藤利和
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 23 Pages: 109-114

    • NAID

      130005395398

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rhotekin modulates differentiation of cultured neural stem cells to neurons2012

    • Author(s)
      Iwai T, Saitoh A, Yamada M, Takahashi K, Hashimoto E, Ukai W, Saito T, Yamada M
    • Journal Title

      J Neurosci Res

      Volume: 90(7) Issue: 7 Pages: 1359-66

    • DOI

      10.1002/jnr.23029

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 経静脈的神経幹細胞移植によるFASDモデルラットの行動異常改善と脳神経回路シナプス形成の修復2012

    • Author(s)
      齋藤利和,鵜飼渉,白坂知彦,橋本恵理,吉永敏弘,金田博雄,五十嵐健史,渡邊公彦,館農勝,石井貴男
    • Journal Title

      アルコールと医学生物学

      Volume: 31 Pages: 40-40

    • Related Report
      2013 Final Research Report
  • [Journal Article] 末梢BDNFは脳神経回路網変化にどう関わるか-血小板BDNF遊離機構に焦点を当てて2012

    • Author(s)
      橋本恵理,鵜飼渉,渡邊公彦,白坂知彦,金田博雄,五十嵐健史,館農勝,吉永敏弘,齋藤利和
    • Journal Title

      精神薬療研究年報

      Volume: 44 Pages: 67-68

    • Related Report
      2012 Research-status Report
  • [Journal Article] 統合失調症の脳神経回路修復 薬物・細胞コンバインド療法の可能性の検討2012

    • Author(s)
      鵜飼 渉, 小野 貴文, 橋本 恵理, 金田 博雄, 白坂 知彦, 五十嵐 健史, 木川 昌康, 渡邊 公彦, 吉永 敏弘, 石井 貴男, 館農 勝, 小林 清樹, 齋藤 利和
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 23 Pages: 109-114

    • NAID

      130005395398

    • Related Report
      2012 Research-status Report
  • [Presentation] 胎生期アルコール曝露と成長後のストレスを組み合わせた難治性うつ病モデルにおける神経幹細胞移植療法の有効性に関する研究2014

    • Author(s)
      鵜飼渉,橋本恵理,木川昌康,石井貴男,古瀬健吾,辻野華子,齋藤利和
    • Organizer
      第33回アルコール医学生物学研究会学術集会
    • Place of Presentation
      高知 (シンポジウム)
    • Related Report
      2013 Final Research Report
  • [Presentation] 胎生期アルコール曝露と成長後のストレスを組み合わせた難治性うつ病モデルにおける神経幹細胞移植療法の有効性に関する研究.2014

    • Author(s)
      鵜飼渉,橋本恵理,木川昌康,石井貴男,古瀬健吾,辻野華子,齋藤利和.
    • Organizer
      第33回アルコール医学生物学研究会学術集会
    • Place of Presentation
      高知
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effects of ethanol and antidepressant on the platelet BDNF release function in the peripheral blood : Implication in the pathogenesis of psychiatric disease2013

    • Author(s)
      Saito T, Hashimoto E, Ukai W, Takao Ishii, Kigawa Y, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T
    • Organizer
      52nd Annual Meeting of The American College of Neuropsychopharmacology (ACNP)
    • Place of Presentation
      Florida
    • Related Report
      2013 Final Research Report
  • [Presentation] 薬物療法と神経新生・神経回路修復2013

    • Author(s)
      鵜飼渉,橋本恵理,石井貴男,木川昌康,古瀬健吾,辻野華子,吉永敏弘,齋藤利和
    • Organizer
      第26回日本総合病院精神医学会総会
    • Place of Presentation
      京都 (シンポジウム)
    • Related Report
      2013 Final Research Report
  • [Presentation] 精神疾患に対する再生医療的アプローチの可能性, 依存研究を基盤にした精神疾患の病因解明の試み2013

    • Author(s)
      鵜飼渉,橋本恵理,石井貴男,木川昌康,古瀬健吾,辻野華子,白坂知彦,吉永敏弘,小林清樹,齋藤利和
    • Organizer
      第23回日本臨床精神神経薬理学会
    • Place of Presentation
      沖縄 (シンポジウム)
    • Related Report
      2013 Final Research Report
  • [Presentation] Stem cell research on Alcoholism. [Symposium] Biomedical Approach on Alcoholism2013

    • Author(s)
      Ukai W, Hashimoto E, Ishii T, Kigawa Y, Yoshinaga T , Watanabe K, Shirasaka T, Tateno M, Kobayashi S, Saito T
    • Organizer
      Regional Meeting of Collegium Internationale Neuro-Psychopharmacologicum (CINP)
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2013 Final Research Report
  • [Presentation] Basic aspects of alcohol use disorder comorbid with depressive disorder2013

    • Author(s)
      Hashimoto E, Ukai W, Ishii T, Kigawa Y, Yoshinaga T, Watanabe K, Shirasaka T, Tateno M, Kobayashi S, Saito T
    • Organizer
      Alcohol abuse comorbidity. 14th Congress of ESBRA
    • Place of Presentation
      Warsaw (Symposium)
    • Related Report
      2013 Final Research Report
  • [Presentation] Understanding of mechanisms underlying brain abnormality in FASD and its translational approach2013

    • Author(s)
      Ukai W, Hashimoto E, Shirasaka T, Ishii T, Yoshinaga T, Kaneta H, Kigawa Y, Tateno M, Kobayashi S, Saito T
    • Organizer
      14th Congress of ESBRA
    • Place of Presentation
      Warsaw (Symposium)
    • Related Report
      2013 Final Research Report
  • [Presentation] Alteration of platelet BDNF release function in the peripheral blood : Implications of alcohol and antidepressant2013

    • Author(s)
      Saito T, Hashimoto E, Ukai W, Takao Ishii, Kigawa M, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T
    • Organizer
      The 3rd Congress of Asian College of Neuropsychopharmacology (AsCNP)
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Usage of peripheral-derived cytokine as a marker and treatment approach for neural plasticity change in alcohol-induced brain damage and depression, Translational perspective on the imaging, epigenetics and peripheral-derived markers for alcohol induced brain damage and depression2013

    • Author(s)
      Hashimoto E, Ukai W, Ishii T, Watanabe K, Shirasaka T, Kaneta H, Kigawa Y, Yoshinaga T, Tateno M, Saito T
    • Organizer
      WFSBP Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto (Symposium)
    • Related Report
      2013 Final Research Report
  • [Presentation] アルコール脳障害の病態理解とその治療的アプローチ2013

    • Author(s)
      鵜飼渉,橋本恵理,白坂知彦,石井貴男,吉永敏弘,金田博雄,木川昌康,館農勝,齋藤利和
    • Organizer
      依存症発症メカニズムの脳科学.第36回日本神経科学大会第56回日本神経化学会大会第23回日本神経回路学会大会合同大会/Neuro2013
    • Place of Presentation
      京都 (シンポジウム)
    • Related Report
      2013 Final Research Report
  • [Presentation] Understanding of mechanisms underlying brain abnormality in FASD and its translational approach.2013

    • Author(s)
      Ukai W, Hashimoto E, Shirasaka T, Ishii T, Yoshinaga T, Kaneta H, Kigawa Y, Tateno M, Kobayashi S, Saito T.
    • Organizer
      14th Congress of ESBRA
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 精神疾患に対する再生医療的アプローチの可能性.2013

    • Author(s)
      鵜飼渉,橋本恵理,石井貴男,木川昌康,古瀬健吾,辻野華子,白坂知彦,吉永敏弘,小林清樹,齋藤利和.
    • Organizer
      第23回日本臨床精神神経薬理学会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 末梢血血小板からの神経栄養因子遊離に及ぼす抗うつ薬の効果とアルコールの影響について2013

    • Author(s)
      石井貴男, 鵜飼渉,橋本恵理,渡邊公彦,金田博雄,木川昌康,白坂知彦,五十嵐健史,吉永敏弘,館農勝,齋藤利和
    • Organizer
      アルコール医学生物学研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] The effect of antipsychotics on GABAergic interneurogenesis in adult brain2012

    • Author(s)
      Ukai W, Kaneta H, Hashimoto E, Igarashi T, Kigawa Y, Shirasaka T, Watanabe K, Yoshinaga T, Tateno M, Ishii T, Saito T
    • Organizer
      28th Collegium Internationale Neuro-Psychopharmacologicum (CINP) Congress
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Cell-based therapy for alcohol-induce brain damage2012

    • Author(s)
      Ukai W, Shirasaka T, Hashimoto E, Kaneta H, Igarashi T, Watanabe k, Yoshinaga T, Tateno M, Ishii T, Saito T
    • Organizer
      The 2nd Congress of Asia-Pacific Society for Alcohol and Addiction Research (APSAAR)
    • Place of Presentation
      Bangkok (Symposium)
    • Related Report
      2013 Final Research Report
  • [Presentation] アルコールによる脳障害に対する新たな治療法の可能性を探る-FASDモデルを用いた検討2012

    • Author(s)
      橋本恵理, 白坂知彦, 吉永敏弘, 金田博雄, 木川昌康, 五十嵐健史, 渡邊公彦, 石井貴男, 鵜飼渉,館農勝, 齋藤利和
    • Organizer
      アルコール・薬物依存関連学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 造血幹細胞移植後の遷延する倦怠感にmirtazapineが奏功した2症例2012

    • Author(s)
      吉永敏弘、米田舞,藤井明美,川口紘史. 山崎克哉, 水口亜紀, 渡辺昭彦, 井山諭
    • Organizer
      日本造血細胞移植学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Presentation] Alcohol reduces the effect of antidepressants on platelet BDNF release

    • Author(s)
      Ishii T, Ukai W, Kigawa Y, Kengo F, Kakutani Y, Hashimoto E, Saito T
    • Organizer
      43nd Annual Meeting of The Society for Neuroscience (SfN)
    • Place of Presentation
      San Diego, California
    • Related Report
      2013 Final Research Report
  • [Book] 幹細胞療法と精神疾患, メンタル医療2013

    • Author(s)
      鵜飼渉,石井貴男,橋本恵理 (糸川昌成監)
    • Publisher
      東京 : シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Book] 気分障害と幹細胞.躁うつ病の薬理・生化学的研究懇話会編.気分障害の薬理・生化学2012

    • Author(s)
      鵜飼渉
    • Publisher
      大阪 : 医薬ジャーナル社
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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