| Project/Area Number |
23591678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401)
UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256)
TATENO Masaru 札幌医科大学, 医学部, 講師 (60464492)
安宅 弘司 札幌医科大学, 医学部, 助教 (30563358)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 精神薬理学 / 顆粒球コロニー刺激因子 / 細胞治療 / 再生医療 / 神経幹細胞 / 神経新生 / 造血幹細胞移植 / G-CSF / 造血幹細胞 / 胎児性アルコールスペクトラム障害 / 骨髄移植 / 精神薬理 / 胎児性アルコールスペクトラム症候群 |
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| Research Abstract |
The purpose of this study is to develop a possible therapeutic approach for psychiatric disorders by neurogenesis upregulation through increase of peripheral hematopoietic stem cells. First, we have demonstrated that the combined peripheral treatment of stem cells and antidepressant, which has been indicated to increase trophic factors in the serum could have potential to recover the abnormal behavior of treatment-resistant refractory depression model. We have also shown that peripherally treated neural stem cells concentrated much in the hypothalamus areas where oxytocin/vasopresinergic neurons exist, and recovered social/cognitive impairment of psychiatric disease model including parental behavior.
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