| Project/Area Number |
23591681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
倉冨 剛 獨協医科大学, 医学部, 助教 (00593592)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 統合失調症 / 認知機能 / BACS-J / 染色体22q11.2-22q12.1領域 / 一塩基多型 / 染色体22q11.2-12.1領域 / 染色体22q11.2領域 |
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| Research Abstract |
The present study investigated whether 127 tagging single nucleotide polymorphisms (SNPs) in the 22q11.2 - 22q12.1 chromosomal region are associated with cognitive impairment in schizophrenia. 240 schizophrenia patients and 240 age-matched healthy controls were recruited, and all of them underwent Japanese-language version of the Brief Assessment of Cognition in Schizophrenia (BACS-J). Associations between gene polymorphisms and z scores of the BACS-J were statistically analyzed by linear regression implemented in PLINK 1.07. Results showed that SNPs in the DGCR2, UFD1L, TBX1, KLHL22, ASPHD2, and HPS4 are significantly associated with BACS-J z-scores. These results warrant further study on association between cognition and genes across the 22q11.2 and 22q12.1
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