| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Development of antidepresant besed on monoamine neuron hypothesis is facing limit. Glia, especially astrocytes, are major in the CNS and play a role of storage for several types of neurotrophic factors such as GDNF and BDNF, which are implicated in antidepressant effects. We revealed the pharmacomolecular mechanism of antidepressant effect on astrocytes. The expression of GDNF and FGF-2 by antidepressant in astrocytes was regulated by monoamine-independent mechanism. We also found five antideressant-related candidates directly targeting asytocyes by using pahrmacoproteomics, and that the pathway of neurotrophic factors expression was involved in the MMP-Tyrosine kinase-ERK-CREB cascade. Identification of specific antidepressant-targeting protein and cascade on astrocytes may contribute to development of antidepressant from a different view point.
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