Identification of novel targets of antidepressant on glia by using pharmacoproteomics
| Project/Area Number |
23591686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Department of Clinical Research, National Hospital Organization Kure Medical Center |
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Principal Investigator |
TAKEBAYASHI Minoru 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 (60304440)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Yoshihiro 広島大学, 薬学部, 教授 (40133152)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 抗うつ薬 / グリア / アストロサイト / 神経栄養因子 / 創薬 / antidepressant / glia / astrocyte / monoamine-independent / GDNF / 気分障害 |
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| Research Abstract |
Development of antidepresant besed on monoamine neuron hypothesis is facing limit. Glia, especially astrocytes, are major in the CNS and play a role of storage for several types of neurotrophic factors such as GDNF and BDNF, which are implicated in antidepressant effects. We revealed the pharmacomolecular mechanism of antidepressant effect on astrocytes. The expression of GDNF and FGF-2 by antidepressant in astrocytes was regulated by monoamine-independent mechanism. We also found five antideressant-related candidates directly targeting asytocyes by using pahrmacoproteomics, and that the pathway of neurotrophic factors expression was involved in the MMP-Tyrosine kinase-ERK-CREB cascade. Identification of specific antidepressant-targeting protein and cascade on astrocytes may contribute to development of antidepressant from a different view point.
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Report
(4 results)
Research Products
(45 results)
