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Systematic evaluation of endophenotypes for patients with at risk mental state and first-episode schizophrenia

Research Project

Project/Area Number 23591687
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionHokkaido University

Principal Investigator

KUSUMI Ichiro  北海道大学, 医学(系)研究科(研究院), 教授 (30250426)

Co-Investigator(Kenkyū-buntansha) ITO Koki  北海道大学, 大学院医学研究科, 助教 (40455663)
YOYOMAKI Atsuhito  北海道大学, 大学院医学研究科, 特任助教 (70515494)
HASHIMOTO Naoki  北海道大学, 大学院医学研究科, 助教 (40615895)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords精神病発症高リスク状態 (ARMS) / 統合失調症 / 中間表現型 / biological motion / 遂行機能 / 作業記憶 / 事象関連同期 / Sternberg課題 / 事象関連電位 / ARMS / スイッチング課題 / 内発課題 / 外発課題 / 社会知覚 / coherent motion / at risk mental state / 認知機能障害
Research Abstract

The ratio of patients with at-risk mental state (ARMS) was 15.9% in 157 first-visit patients (16-30 y.o) at psychiatric clinic or hospitals in Hokkaido. Biological motion perception, neural response in endogenous rule shifting, and neural oscillations during Sternberg task in schizophrenia patients were significantly different from normal controls, which suggests that these markers are useful as endophenotypes of schizophrenia.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results)

  • [Journal Article] Discrepancy of neural response between exogenous and endogenous task switching: an event-related potentials study2012

    • Author(s)
      Miyajima M
    • Journal Title

      Neuroreport

      Volume: 23(11) Issue: 11 Pages: 642-646

    • DOI

      10.1097/wnr.0b013e328354b066

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of explicit instruction on Japanese Verbal Learning Test in patients with schizophrenia2011

    • Author(s)
      Hashimoto N, Matsui M, Kusumi I, Toyomaki A, Ito K, Kako Y, Koyama T
    • Journal Title

      Psychiatry Res

      Volume: 188 Issue: 2 Pages: 289-290

    • DOI

      10.1016/j.psychres.2010.06.024

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of explicit instruction on Japanese Verbal Learning Test in patients with schizophrenia2011

    • Author(s)
      Hashimoto N, Matsui M, Kusumi I, Toyomaki A, Ito K, Kako Y, Koyama T
    • Journal Title

      Psychiatry Res

      Volume: 188 Pages: 289-290

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Difference of reward system activation in patients with schizophrenia treated with olanzapine, blonanserin and aripiprazole-2nd report2013

    • Author(s)
      Naoki Hashimoto, Atsuhito Toyomaki, Tamaki Miyamoto, Ichiro Kusumi
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 統合失調症における作業記憶課題遂行時の事象関連電位・事象関連同期の異常2013

    • Author(s)
      宮島真貴, 豊巻敦人, 清水祐輔, 橋本直樹, 宮崎茜, 久住一郎
    • Organizer
      第47回日本作業療法学会
    • Place of Presentation
      大阪国際会議場, 大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] Working memory deficits in schizophrenia: an event-related potentials study2013

    • Author(s)
      Miyazaki A, Toyomaki A, Hashimoto N, Kusumi I
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] 健常者における作業記憶課題遂行時のERP2013

    • Author(s)
      宮崎茜, 豊巻敦人, 久住一郎
    • Organizer
      第31回日本生理心理学会大会
    • Place of Presentation
      福井大学,福井
    • Related Report
      2013 Final Research Report
  • [Presentation] Difference of reward system activation in patients with schizophrenia treated with olanzapine, blonanserin and aripiprazole-2nd report2013

    • Author(s)
      Naoki Hashimoto, Atsuhito Toyomaki, Tamaki Miyamoto, Ichiro Kusumi
    • Organizer
      43th Annual Meeting Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center (San Diego, CA, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Working memory deficits in schizophrenia : an event-related potentials study2013

    • Author(s)
      Miyazaki A ,Toyomaki A, Hashimoto N, Kusumi I
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto International Conference Center (Kyoto, Japan)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 統合失調症における作業記憶課題遂行時の事象関連電位・事象関連同期の異常2013

    • Author(s)
      宮島真貴、豊巻敦人、清水祐輔、橋本直樹、宮崎茜、久住一郎
    • Organizer
      第47回日本作業療法学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 健常者における作業記憶課題遂行時のERP2013

    • Author(s)
      宮崎茜、豊巻敦人、久住一郎
    • Organizer
      第31回日本生理心理学会大会
    • Place of Presentation
      福井大学(福井)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 統合失調症におけるrule shiftingの処理過程の解明~事象関連電位による検討~2012

    • Author(s)
      宮島真貴,豊巻敦人,久住一郎,小山司
    • Organizer
      第43回北海道作業療法学会
    • Place of Presentation
      コンベンションセンター, 札幌
    • Year and Date
      2012-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of neural responses between exogenous and endogenous rule shifting in cued switching task; an ERPs study2012

    • Author(s)
      Miyajima M, Toyomaki A, Kusumi I, Koyama T
    • Organizer
      The 34th Annual Cognitive Science Conference
    • Place of Presentation
      コンベンションセンター, 札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Task switchingにおける内発・外発的ルール切り替え時の事象関連電位の相違2012

    • Author(s)
      宮島真貴,豊巻敦人,室橋春光,久住一郎,小山司
    • Organizer
      第30回日本生理心理学会
    • Place of Presentation
      北海道大学, 札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of neural responses between exogenous and endogenous rule shifting in cued switching task; an ERPs study2012

    • Author(s)
      Miyajima M,Toyomaki A,Kusumi I,Koyama T
    • Organizer
      The 34th Annual Cognitive Science Conference
    • Place of Presentation
      コンベンションセンター(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] Task switchingにおける内発・外発的ルール切り替え時の事象関連電位の相違2012

    • Author(s)
      宮島真貴,豊巻敦人,室橋春光,久住一郎,小山 司
    • Organizer
      第30回日本生理心理学会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 統合失調症患者におけるcoherent motion 知覚とbiological motion知覚の関連および臨床背景との相関の検討2011

    • Author(s)
      橋本直樹、久住一郎、豊巻敦人、賀古勇輝、朴 秀賢、伊藤候輝、小山 司
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] 統合失調症におけるrule shiftingの処理過程の解明~事象関連電位による検討~

    • Author(s)
      宮島真貴,豊巻敦人,久住一郎,小山 司
    • Organizer
      第43回北海道作業療法学会
    • Place of Presentation
      コンベンションセンター(北海道)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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