Systematic evaluation of endophenotypes for patients with at risk mental state and first-episode schizophrenia
| Project/Area Number |
23591687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KUSUMI Ichiro 北海道大学, 医学(系)研究科(研究院), 教授 (30250426)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Koki 北海道大学, 大学院医学研究科, 助教 (40455663)
YOYOMAKI Atsuhito 北海道大学, 大学院医学研究科, 特任助教 (70515494)
HASHIMOTO Naoki 北海道大学, 大学院医学研究科, 助教 (40615895)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 精神病発症高リスク状態 (ARMS) / 統合失調症 / 中間表現型 / biological motion / 遂行機能 / 作業記憶 / 事象関連同期 / Sternberg課題 / 事象関連電位 / ARMS / スイッチング課題 / 内発課題 / 外発課題 / 社会知覚 / coherent motion / at risk mental state / 認知機能障害 |
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| Research Abstract |
The ratio of patients with at-risk mental state (ARMS) was 15.9% in 157 first-visit patients (16-30 y.o) at psychiatric clinic or hospitals in Hokkaido. Biological motion perception, neural response in endogenous rule shifting, and neural oscillations during Sternberg task in schizophrenia patients were significantly different from normal controls, which suggests that these markers are useful as endophenotypes of schizophrenia.
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Report
(4 results)
Research Products
(18 results)
