Pathological and biochemical study of dementia as a combined protein accumulation disease

• Project/Area Number: 23591694
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Tsukuba
• Principal Investigator: ARAI Tetsuaki 筑波大学, 医学医療系, 准教授 (90291145)
• Co-Investigator(Renkei-kenkyūsha): HASEGAWA Masato (10251232)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 認知症 / 蛋白質 / 蓄積 / 変性

Research Abstract

TDP-43, FUS and tau are the major components of the neuronal and glial inclusions in a variety of neurodegenerative disorders. The distributions of these proteins were related to the clinical features in most disorders. The combined accumulation of these proteins frequently occurred in many of neurodegenerative disorders, including frontotemporal lobar degeneration, motor neuron diseases and diffuse neurofibrillary tangles with calcification. Methylene blue reduced tau accumulation in mice harboring tau gene mutation, suggesting that inhibition of tau aggregation by it may have potential as a drug candidate for the treatment of tauopathy. The results of the present study suggest developing the methods to detect each protein in biological fluids may be important for the diagnosis and the disease modifying therapy for the diseases.

Research Products

• [Journal Article] Significance and limitation of the pathological classification of TDP-43 proteinopathy (2014)
  • Author(s): Arai T
  • Journal Title: Neuropathology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia (2014)
  • Author(s): Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Katsuse O, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
  • Journal Title: Acta Neuropathol Volume: Commun 2 Issue: 1 Pages: 40-40
  • DOI: 10.1186/2051-5960-2-40
  • Peer Reviewed / Open Access
• [Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain–Barre´ syndrome by quantitative determination of TDP-43 in cerebrospinal fluid (2014)
  • Author(s): Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H
  • Journal Title: Int J Neurosci Volume: 124 Pages: 344-349
  • Peer Reviewed
• [Journal Article] Relative Ratio and Level of Amyloid-β 42 Surrogate in Cerebrospinal Fluid of Familial Alzheimer Disease Patients with Presenilin 1 Mutations (2014)
  • Author(s): Tagami et al.
  • Journal Title: Neurodegenerative Disease Volume: 13 Issue: 2-3 Pages: 166-170
  • DOI: 10.1159/000355258
  • Peer Reviewed / Open Access
• [Journal Article] Ratio and lebel of Aß surrogate in cerebrospinal fluid of familal Alzheimer’s disease patients with presenilin 1 mutations. (2014)
  • Author(s): Tagami S, Okochi M, Yanagida K, Kodama T, Arai T, Kuwano R, Ikeuchi T, Takeda M
  • Journal Title: Neurodegener Dis Volume: 13 Pages: 166-170
  • Peer Reviewed
• [Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain–Barre´ syndrome by quantitative determination of TDP-43 in cerebrospinal fluid. (2014)
  • Author(s): Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H
  • Journal Title: Int J Neurosci Volume: 124 Pages: 344-349
  • Peer Reviewed
• [Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions. (2014)
  • Author(s): Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, Hosokawa M, Akiyama H, Hasegawa M
  • Journal Title: Hum Mol Genet Volume: in press
  • Peer Reviewed
• [Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia. (2014)
  • Author(s): Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Omi K, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
  • Journal Title: Acta Neuropathol Commun Volume: in press
  • Peer Reviewed
• [Journal Article] Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains. (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M.
  • Journal Title: Cell Rep. Volume: 4 Issue: 1 Pages: 124-34
  • DOI: 10.1016/j.celrep.2013.06.007
  • Peer Reviewed
• [Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases. (2013)
  • Author(s): Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H.
  • Journal Title: Neurol. Sci. Volume: 335 Issue: 1-2 Pages: 89-95
  • DOI: 10.1016/j.jns.2013.08.035
  • Peer Reviewed
• [Journal Article] Thalamic hypoperfusion in early stage of progressive supranuclear palsy (Richardson's syndrome): Report of an autopsy-confirmed case (2013)
  • Author(s): Kobayashi Z, Akaza M, Ishihara S, Tomimitsu H, Inadome Y, Arai T, Akiyama H, Shintani S
  • Journal Title: J Neurol Sci Volume: 335 Issue: 1-2 Pages: 224-227
  • DOI: 10.1016/j.jns.2013.09.005
  • Peer Reviewed
• [Journal Article] Atypical FTLD-FUS associated with ALS-TDP : a case report (2013)
  • Author(s): Kobayashi Z, Arai T, Yokota O, Tsuchiya K, Hosokawa M, Oshima K, Niizato K, Akiyama H, Mizusawa H
  • Journal Title: Neuropathology Volume: 33 Issue: 1 Pages: 83-86
  • DOI: 10.1111/j.1440-1789.2012.01325.x
  • Peer Reviewed
• [Journal Article] Prion-like spreading of pathological alpha-synuclein in brain. (2013)
  • Author(s): Masuda-Suzukake M, Nonaka T, Hosokawa M., Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
  • Journal Title: Brain Volume: 136 Issue: 4 Pages: 1128-38
  • DOI: 10.1093/brain/awt037
  • Peer Reviewed
• [Journal Article] 認知症性疾患の病理・分子対応 (2013)
  • Author(s): 新井哲明
  • Journal Title: Cognition and Dementia Volume: 12 Pages: 48-55
• [Journal Article] 前頭側頭葉変性症の病理と関連遺伝子 (2013)
  • Author(s): 細川雅人,新井哲明
  • Journal Title: Clinical Neuroscinece Volume: 12 Pages: 1435-1437
• [Journal Article] Atypical FTLD-FUS associated with ALS-TDP: a case report. (2013)
  • Author(s): Kobayashi Z, Arai T, Yokota O, Tsuchiya K, Hosokawa M, Oshima K, Niizato K, Akiyama H, Mizusawa H
  • Journal Title: Neuropathology Volume: 33 Pages: 83-86
  • Peer Reviewed
• [Journal Article] Prion-like spreadding of pathological alpha-synuclein in brain. (2013)
  • Author(s): Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
  • Journal Title: Brain Volume: 136 Pages: 1128-1138
  • Peer Reviewed
• [Journal Article] Prion-like properties of pathological TDP-43 aggregates from diseased brains. (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DMA, Akiyama H, Hasegawa M
  • Journal Title: Cell Rep Volume: 4 Pages: 124-134
  • Peer Reviewed
• [Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases. (2013)
  • Author(s): Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H
  • Journal Title: J Neurol Sci Volume: 335 Pages: 89-95
  • Peer Reviewed
• [Journal Article] Thalamic hypoperfusion in early stage of progressive supranuclear palsy (Richardson's syndrome): Report of an autopsy-confirmed case. (2013)
  • Author(s): Kobayashi Z, Akaza M, Ishihara S, Tomimitsu H, Inadome Y, Arai T, Akiyama H, Shintani S
  • Journal Title: J Neurol Sci Volume: 335 Pages: 224-227
  • Peer Reviewed
• [Journal Article] Reducing TDP-43 aggregation does not prevent its cytotoxicity. (2013)
  • Author(s): Liu R, Yang G, Nonaka T, Arai T, Jia W, Cynader MS
  • Journal Title: Acta Neuropathol Commun Volume: 1 Pages: 49-49
  • Peer Reviewed
• [Journal Article] Post mortem cerebrospinal fluidα-synuclein levels are raised in multiple system atrophy and distinguish this from the otherα-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies (2012)
  • Author(s): Foulds PG, Yokota O, Thurston A, Davidson Y, Ahmed Z, Holton J, Thompson JC, Akiyama H, Arai T, Hasegawa M, Gerhard A, Allsop D, Mann DM
  • Journal Title: Neurobiol Dis Volume: 45 Issue: 1 Pages: 188-95
  • DOI: 10.1016/j.nbd.2011.08.003
  • Peer Reviewed
• [Journal Article] Progressive nonfluent aphasia : A rare clinical subtype of FTLD-TDP in Japan (2012)
  • Author(s): Aoki N, Tsuchiya K, Kobayashi Z, Arai T, Togo T, Miyazaki H, Kondo H, Ishizu H, Uchikado H, Katsuse O, Hirayasu Y, Akiyama H
  • Journal Title: Neuropathology Volume: (in press) Issue: 3 Pages: 272-9
  • DOI: 10.1111/j.1440-1789.2011.01253.x
  • Peer Reviewed
• [Journal Article] Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: A postmortem study (2012)
  • Author(s): Torii Y, Iritani S, Sekiguchi H, Habuchi C, Hagikura M, Arai T, Ikeda K, Akiyama H, Ozaki N
  • Journal Title: Schizophr Res Volume: 134(2-3) Issue: 2-3 Pages: 137-142
  • DOI: 10.1016/j.schres.2011.10.024
  • Peer Reviewed
• [Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy (2012)
  • Author(s): Tsuji H
  • Journal Title: Brain Volume: 135(11) Issue: 11 Pages: 3380-91
  • DOI: 10.1093/brain/aws230
  • Peer Reviewed
• [Journal Article] Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice. (2012)
  • Author(s): Hosokawa M
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: e52389-e52389
  • DOI: 10.1371/journal.pone.0052389
  • Peer Reviewed
• [Journal Article] 32歳で発症した舞踏病様不随意運動を伴う前頭側頭型認知症の一例 (2012)
  • Author(s): 河上緒, 新里和弘, 新井哲明, 大島健一, 安野みどり, 湯本洋介, 小幡奈々子, 新井誠, 糸川昌成, 後藤順, 市川弥生子, 平安良雄, 岡崎祐士, 秋山治彦
  • Journal Title: 老年精神医学雑誌 Volume: 23 Pages: 1121-1127
  • Peer Reviewed
• [Journal Article] レビ-小体型認知症の神経変性機序・分子生物学 (2012)
  • Author(s): 野中隆, 新井哲明, 水上勝義, 長谷川成人
  • Journal Title: 老年精神医学雑誌 Volume: 23 Pages: 353-358
• [Journal Article] 前頭側頭葉変性症の分子病理 (2012)
  • Author(s): 新井哲明
  • Journal Title: 老年期認知症研究会誌 Volume: 19 Pages: 60-62
  • NAID: 10026310255
• [Journal Article] 前頭側頭葉変性症の分子医学 (2012)
  • Author(s): 新井哲明, 細川雅人, 野中隆, 長谷川成人, 秋山治彦, 朝田隆
  • Journal Title: Dementia Japan Volume: 26 Pages: 334-342
• [Journal Article] 早期診断と医療連携, 知症医療のおける課題 (2012)
  • Author(s): 新井哲明, 水上勝義
  • Journal Title: Medicament News Volume: 第2090号 Pages: 4-5
• [Journal Article] Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson’s disease and Dementia with Lewy bodies. (2012)
  • Author(s): Foulds PG, Yokota O, Thurston A, Davidson Y, Ahmed Z, Holton J, Thompson JC, Akiyama H, Arai T, Hasegawa M, Gerhard A, Allsop D, Mann DMA
  • Journal Title: Neurobiol Dis Volume: 45 Pages: 188-195
  • Peer Reviewed
• [Journal Article] Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in Japan. (2012)
  • Author(s): Aoki N, Tsuchiya K, Kobayashi Z, Arai T, Togo T, Miyazaki H, Kondo H, Ishizu H, Uchikado H, Katsuse O, Hirayasu Y, Akiyama H
  • Journal Title: Neuropathology Volume: 32 Pages: 272-279
  • Peer Reviewed
• [Journal Article] Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia. (2012)
  • Author(s): Torii Y, Iritani S, Sekiguchi H, Habuchi C, Hagikura M, Arai T, Ikeda K, Akiyama H, Ozaki N
  • Journal Title: Schizophr Res Volume: 134 Pages: 137-142
  • Peer Reviewed
• [Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy. (2012)
  • Author(s): Tsuji H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuda H, Takao M, Saito Y, Murayama S, Akiyama H, Hasegawa M, Mann DMA, Tamaoka A
  • Journal Title: Brain Volume: 135 Pages: 3380-3391
  • Peer Reviewed
• [Journal Article] Methylene blue reduced phosphorylated tau accumulation in P301L tau transgenic mice. (2012)
  • Author(s): Hosokawa M, Arai T, Masuda-Suzukake M, Yamashita M, Nonaka T, Akiyama H, Hasegawa M
  • Journal Title: PLoS ONE Volume: 7
  • Peer Reviewed
• [Journal Article] 32歳で発症した舞踏病様不随意運動を伴う前頭側頭型認知症の一例. (2012)
  • Author(s): 河上緒, 新里和弘, 新井哲明, 大島健一, 安野みどり, 湯本洋介, 小幡奈々子, 新井誠, 糸川昌成, 後藤順, 市川弥生子, 平安良雄, 岡崎祐士, 秋山治彦
  • Journal Title: 老年精神医学雑誌 Volume: 23 Pages: 1121-1127
  • Peer Reviewed
• [Journal Article] レビ-小体型認知症の神経変性機序・分子生物学. (2012)
  • Author(s): 野中隆, 新井哲明, 水上勝義, 長谷川成人
  • Journal Title: 老年精神医学雑誌 Volume: 23 Pages: 353-358
• [Journal Article] 前頭側頭葉変性症の分子病理. (2012)
  • Author(s): 新井哲明
  • Journal Title: 老年期認知症研究会誌 Volume: 19 Pages: 60-62
  • NAID: 10026310255
• [Journal Article] 前頭側頭葉変性症の分子医学. (2012)
  • Author(s): 新井哲明, 細川雅人, 野中隆, 長谷川成人, 秋山治彦, 朝田隆
  • Journal Title: Dementia Japan Volume: 26 Pages: 334-342
• [Journal Article] 早期診断と医療連携. (2012)
  • Author(s): 新井哲明, 水上勝義
  • Journal Title: Medicament News Volume: 2090 Pages: 4-5
• [Journal Article] Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: A postmortem study. (2012)
  • Author(s): Torii Y, Iritani S, Sekiguchi H, Habuchi C, Hagikura M, Arai T, Ikeda K, Akiyama H, Ozaki N
  • Journal Title: Schizophr Res Volume: 134 Pages: 137-142
  • Peer Reviewed
• [Journal Article] N-cadherin regulates p38MAPK signaling via association with JLP : Implications for neurodegeneration in Alzheimer's disease (2011)
  • Author(s): Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
  • Journal Title: J Biol Chem Volume: 286 Issue: 9 Pages: 7619-28
  • DOI: 10.1074/jbc.m110.158477
  • Peer Reviewed
• [Journal Article] Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy (2011)
  • Author(s): Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
  • Journal Title: J Neurol Sci Volume: 301 Issue: 1-2 Pages: 77-85
  • DOI: 10.1016/j.jns.2010.10.021
  • Peer Reviewed
• [Journal Article] Gray matter lesions in Nasu-Hakola disease : A report on three autopsy ca (2011)
  • Author(s): Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Anno M, Kosaka K, Akiyama H, Hirayasu Y
  • Journal Title: Neuropathology Volume: 31 Issue: 2 Pages: 135-143
  • DOI: 10.1111/j.1440-1789.2010.01152.x
  • Peer Reviewed
• [Journal Article] FALS with Gly72Ser mutation in SOD1 gene : Report of a family including the first autopsy case (2011)
  • Author(s): Kobayashi Z, Tsuchiy Kobayashi Z, Tsuchiya K, Kubodera T, Shibata N, Arai T, Miura H, Ishikawa C, Kondo H, Ishizu H, Akiyama H, Mizusawa H
  • Journal Title: Neurol Sci Volume: 300 Issue: 1-2 Pages: 9-13
  • DOI: 10.1016/j.jns.2010.10.030
  • NAID: 120007137590
  • Peer Reviewed
• [Journal Article] Fatal encephalitis in a case of hypereosinophilic syndrome : MRI and autopsy findings (2011)
  • Author(s): Kobayashi Z, Tsuchiya K, Komachi H, Miki K, Yokota O, Arai T, Hirotomo M, Ishizu H, Akiyama H, Mizusawa H
  • Journal Title: Intern Med Volume: 50 Pages: 1219-1225
  • NAID: 130000770476
  • URL: https://www.jstage.jst.go.jp/article/internalmedicine/50/11/50_11_1219/_article
  • Peer Reviewed
• [Journal Article] FUS/TLS遺伝子変異による家族性ALS (2011)
  • Author(s): 小林禅, 新井哲明, 秋山治彦, 水澤英洋
  • Journal Title: Clinical Neuroscience Volume: 29 Pages: 734-735
• [Journal Article] TDP-43分子による新たな認知症群 (2011)
  • Author(s): 新井哲明, 細川雅人, 長谷川成人, 秋山治彦, 朝田隆
  • Journal Title: 精神経誌 Volume: 113 Pages: 574-583
  • NAID: 10029576302
• [Journal Article] Molecular Dissection of TDP-43 Proteinopathies (2011)
  • Author(s): Hasegawa M, Nonaka T, Tsuji H, et al
  • Journal Title: J Mol Neurosci Volume: 45(3) Issue: 3 Pages: 480-5
  • DOI: 10.1007/s12031-011-9571-x
  • Peer Reviewed
• [Journal Article] 生活習慣病および環境因子の関与と予防, 高血圧・高脂血症 (2011)
  • Author(s): 新井哲明, 朝田隆
  • Journal Title: 臨床と研究 Volume: 88 Pages: 709-713
• [Journal Article] Rivastigmineの開発経緯 (2011)
  • Author(s): 新井哲明, 朝田隆
  • Journal Title: 臨床精神薬理 Volume: 14 Pages: 1131-1135
• [Journal Article] 2.新しい認知症治療薬, 1)リバスチグミン (2011)
  • Author(s): 新井哲明, 朝田隆
  • Journal Title: Geriat Med Volume: 49 Pages: 767-770
• [Journal Article] TDP-43 (2011)
  • Author(s): 新井哲明
  • Journal Title: 認知症学(上), 日本臨床増刊号 Volume: 69 Pages: 84-87
• [Journal Article] TDP-43陽性神経細胞内封入体を伴う前頭側頭葉変性症と認知症を伴う筋萎縮性側索硬化症 (2011)
  • Author(s): 岸本由紀,横田修,武田直也,池田智香子,新井哲明
  • Journal Title: 認知症学(下), 日本臨床増刊号 Volume: 69 Pages: 384-388
• [Journal Article] ALSD-FTLD-MND-FTLD-U (2011)
  • Author(s): 新井哲明, 小林禅, 細川雅人, 長谷川成人, 秋山治彦
  • Journal Title: Clinical Neuroscience Volume: 29 Pages: 995-998
• [Journal Article] アルツハイマー病のサイエンス : 最新の動向 (2011)
  • Author(s): 新井哲明, 朝田隆
  • Journal Title: ANTI-AGING MEDICINE Volume: 7 Pages: 704-710
  • NAID: 40019035470
• [Journal Article] 前頭側頭葉変性症の分子病理 (2011)
  • Author(s): 新井哲明, 山下万貴子, 細川雅人, 野中隆, 小林禅, 長谷川成人, 秋山治彦, 朝田隆
  • Journal Title: Dementia Japan Volume: 25 Pages: 120-128
  • NAID: 10026310255
• [Journal Article] 病理構造物の解析からみちびかれた精神神経疾患の新しい考え方 (2011)
  • Author(s): 長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 秋山治彦
  • Journal Title: 精神医学 Volume: 53 Pages: 1201-1206
• [Journal Article] N-cadherin regulates p38MAPK signaling via association with JLP: Implications for neurodegeneration in Alzheimer’s disease. (2011)
  • Author(s): Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
  • Journal Title: J Biol Chem Volume: 286 Pages: 7619-28
  • Peer Reviewed
• [Journal Article] Clinicopathological study of diffuse neurofibrillary tangles with calcification - With special reference to TDP-43 proteinopathy and alpha-synucleinopathy - (2011)
  • Author(s): Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
  • Journal Title: J Neurol Sci Volume: 301 Pages: 77-85
  • Peer Reviewed
• [Journal Article] FALS with Gly72Ser mutation in SOD1 gene: report of a family including the first autopsy case. (2011)
  • Author(s): Kobayashi Z, Tsuchiya K, Kubodera T, Shibata N, Arai T, Miura H, Ishikawa C, Kondo H, Ishizu H, Akiyama H, Mizusawa H
  • Journal Title: J Neurol Sci Volume: 300 Pages: 9-13
  • NAID: 120007137590
  • Peer Reviewed
• [Journal Article] Fatal encephalitis in a case of hypereosinophilic syndrome: MRI and autopsy findings. (2011)
  • Author(s): Kobayashi Z, Tsuchiya K, Komachi H, Miki K, Yokota O, Arai T, Hirotomo M, Ishizu H, Akiyama H, Mizusawa H
  • Journal Title: Intern Med Volume: 50 Pages: 1219-1225
  • NAID: 130000770476
  • Peer Reviewed
• [Journal Article] Molecular dissection of TDP-43 proteinopathies. (2011)
  • Author(s): Hasegawa M, Nonaka T, Tsuji H, Tamaoka A, Yamashita M, Kametani F, Yoshida M, Arai T, Akiyama H
  • Journal Title: J Mol Neurosci Volume: 45 Pages: 480-485
• [Journal Article] 生活習慣病および環境因子の関与と予防. 高血圧・高脂血症. (2011)
  • Author(s): 新井哲明,朝田隆
  • Journal Title: 臨床と研究 Volume: 88 Pages: 709-713
• [Journal Article] リバスチグミン (2011)
  • Author(s): 新井哲明,朝田隆
  • Journal Title: Geriat Med Volume: 49 Pages: 767-770
• [Journal Article] TDP-43 (2011)
  • Author(s): 新井哲明
  • Journal Title: 日本臨床増刊号. 認知症学(上) Volume: 69 Pages: 84-87
• [Journal Article] TDP-43陽性神経細胞内封入体を伴う前頭側頭葉変性症と認知症を伴う筋萎縮性側索硬化症 (2011)
  • Author(s): 岸本由紀，横田修，武田直也，池田智香子，新井哲明
  • Journal Title: 日本臨床増刊号. 認知症学(下) Volume: 69 Pages: 384-388
• [Journal Article] アルツハイマー病のサイエンス: 最新の動向 (2011)
  • Author(s): 新井哲明,朝田隆
  • Journal Title: ANTI-AGING MEDICINE Volume: 7 Pages: 704-710
  • NAID: 40019035470
• [Presentation] 茨城県内2地域における認知症疫学調査の比較 (2013)
  • Author(s): 池嶋千秋, 吉村敦子, 久永明人, 根本清貴, 高橋晶, 文鐘玉, 井上操, 新井哲明, 朝田隆
  • Organizer: 第28回日本老年精神医学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-06-05
• [Presentation] 延髄呼吸中枢病変を認めた進行性核上性麻痺の1剖検例 (2013)
  • Author(s): 小林禅, 赤座実穂, 石原正一郎, 沼沢祥行, 富満弘之, 鵜浦康司, 稲留征典, 新井哲明, 新谷周三
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-26
• [Presentation] Prion-like properties of pathological TDP-43 in diseased brains (2013)
  • Author(s): 野中隆, 鈴掛雅美, 新井哲明, 赤津裕泰, 小尾智一, 吉田眞理, 村山繁雄, Mann D, 秋山治彦, 長谷川成人
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-25
• [Presentation] レビー小体型認知症患者脳不溶性画分の脳内接種は野生型マウス脳にレビー小体様病理を形成させる (2013)
  • Author(s): 鈴掛雅美, 野中隆, 細川雅人, 笈川貴行, 新井哲明, 秋山治彦, Mann D, 長谷川成人
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-25
• [Presentation] tangle-predominant dementiaの側座核におけ病理学的検討 (2013)
  • Author(s): 河上緒, 長谷川成人, 新井哲明, 青木直哉, 勝瀬大海, 東晋二, 大島健一, 新里和弘, 近藤ひろみ, 羽賀千恵, 下村洋子, 山下万貴子, 鈴木京子, 平安良雄, 秋山治彦
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-25
• [Presentation] 32歳時に抑うつ症状で発病し舞踏病様不随意運動を伴った認知症例 (2013)
  • Author(s): 河上緒, 新井哲明, 新里和弘, 大島健一, 秋山治彦
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-24
• [Presentation] タウオパチー病理変化の基礎.ホットトピックス徹底討論「新時代に向けたタウオパチー研究集中講座」 (2013)
  • Author(s): 新井哲明
  • Organizer: 第32回日本認知症学会学術集会
  • Place of Presentation: 松本, 長野
• [Presentation] 舞踏病様不随意運動を呈するFTLD-FUSの臨床病理学的検討 (2013)
  • Author(s): 河上緒, 新井哲明, 横田修, 新里和弘, 大島健一, 勝瀬大海, 松下正明, 平安良雄, 秋山治彦
  • Organizer: 第32回日本認知症学会学術集会
  • Place of Presentation: 長野
• [Presentation] Tau pathology in the parahippocampal region is related to delusion in the elderly : neuropathological study of two autopsy cases (2013)
  • Author(s): Arai T, Kawakami I, Mizukami K, Ikeda K, Oshima K, Niizato K, Kobayashi Z, Hosokawa M, Nonaka T, Hasegawa M, Akiyama H, Asada T
  • Organizer: Alzheimer's Association International Conference 2013
  • Place of Presentation: Boston, USA
• [Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann D, Akiyama H, Hasegawa M
  • Organizer: Alzheimer's Association International Conference 2013
  • Place of Presentation: Boston, USA
• [Presentation] Alpha-synuclein pathology in the medulla oblongata in association with the reduction of the ventilatory response to hypercapnia in dementia with Lewy bodies and Parkinson's Disease (2013)
  • Author(s): Takahashi S, Arai T, Mizukami K, Kondo H, Oshima K, Niizato, K, Hosokawa M, Akiyama H, Asada T
  • Organizer: Alzheimer's Association International Conference 2013
  • Place of Presentation: Boston, USA
• [Presentation] Prion-like properties of pathological TDP-43 aggregates in diseased brains (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Yoshida M, Murayama S, Mann D, Akiyama H, Hasegawa M
  • Organizer: The 11th International Conference on Alzheimer's and Parkinson's disease
  • Place of Presentation: Florence, Italy
• [Presentation] Pathological background of the ventilatory response to hypercapnia in Dementia with Lewy Bodies and Parkinson's Disease (2013)
  • Author(s): Takahashi S, Arai T, Mizukami K, Kondo H, Oshima K, Niizato, K, Hosokawa M, Akiyama H, Asada T
  • Organizer: The 11th International Conference on Alzheimer's and Parkinson's disease
  • Place of Presentation: Florence, Italy
• [Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties. (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann D, Akiyama H, Hasegawa M
  • Organizer: lzheimer’s Association International Conference 2013
  • Place of Presentation: Boston, USA
• [Presentation] Alpha-synuclein pathology in the medulla oblongata in association with the reduction of the ventilatory response to hypercapnia in dementia with Lewy bodies and Parkinson’s Disease. (2013)
  • Author(s): Takahashi S, Arai T, Mizukami K, Kondo H, Oshima K, Niizato, K, Hosokawa M, Akiyama H, Asada T
  • Organizer: Alzheimer’s Association International Conference 2013
  • Place of Presentation: Boston, USA
• [Presentation] Tau pathology in the parahippocampal region is related to delusion in the elderly: neuropathological study of two autopsy cases. (2013)
  • Author(s): Arai T, Kawakami I, Mizukami K, Ikeda K, Oshima K, Niizato K, Kobayashi Z, Hosokawa M, Nonaka T, Hasegawa M, Akiyama H, Asada T
  • Organizer: Alzheimer’s Association International Conference 2013
  • Place of Presentation: Boston, USA
• [Presentation] Accumulation of phosphorylated and cleaved TDP-43 in neurodegenerative disorders (2012)
  • Author(s): Arai T
  • Organizer: Seoul Neuropathology Forum
  • Place of Presentation: Seoul
  • Year and Date: 2012-12-08
• [Presentation] 中枢性呼吸障害の存在が示唆された進行性核上性麻痺の1剖検例 (2012)
  • Author(s): 小林禅, 赤座実穂, 石原正一郎, 沼沢祥行, 富満弘之, 鵜浦康司, 稲留征典, 新井哲明, 新谷周三
  • Organizer: 第592回日本内科学会関東地方会
  • Place of Presentation: 日内会館,東京
  • Year and Date: 2012-11-10
• [Presentation] 前頭側頭葉変性症 (2012)
  • Author(s): 新井哲明
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば
  • Year and Date: 2012-10-27
• [Presentation] 老年期発症の幻覚妄想を認め、辺縁系に高度タウ病変を認めた3剖検例 (2012)
  • Author(s): 河上緒, 新井哲明, 池田研二, 大島健一, 新里和弘, 東晋二, 青木直哉, 水上勝義, 平安良雄, 秋山治彦
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば
  • Year and Date: 2012-10-26
• [Presentation] レビー小体型認知症とパーキンソン病における延髄のαシヌクレイン陽性構造の比較検討 (2012)
  • Author(s): 高橋晶, 新井哲明, 水上勝義, 近藤ひろみ, 大島健一, 新里和弘, 細川雅人, 秋山治彦, 朝田隆
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば
  • Year and Date: 2012-10-26
• [Presentation] シード依存的な細胞内TDP-43蓄積による細胞死の誘導 (2012)
  • Author(s): 野中隆, 鈴掛(増田)雅美, 新井哲明, 吉田眞理, 村山繁雄, Mann David, 秋山治彦, 長谷川成人
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば
  • Year and Date: 2012-10-26
• [Presentation] Three autopsy cases of FTD-MND with progressive aphasia (2012)
  • Author(s): Kawakami I, Higashi S, Aoki N, Niizto K, Ohshima K, Katsuse O, Togo T, Kobayashi Z, Hosokawa M, Tsuji H, Tamaoka A, Hasegawa M, Arai T, Tsuchiya K, Hirayasu Y, Akiyama H
  • Organizer: The 8^<th> International Conference on Frontotemporal Dementias
  • Place of Presentation: Manchester, UK
  • Year and Date: 2012-09-15
• [Presentation] Intracellular seeding model reproduces characteristic features of affected neurons in TDP-43 proteinopathy (2012)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Yoshida M, Murayama S, Man DMA, Akiyama H, Hasegawa M
  • Organizer: The 8^<th> International Conference on Frontotemporal Dementias
  • Place of Presentation: Manchester, UK
  • Year and Date: 2012-09-15
• [Presentation] Screening of the SOD1, TARDBP and FUS mutations and the pathological studies in Japanese cases with familial and sporadic amyotrophic lateral sclerosis (2012)
  • Author(s): Arai T, Arai M, Itokawa M, Yoshida M, Tamaoka A, Kobayashi Z, Hosokawa M, Hasegawa M, Nonaka T, Tsuji H, Yamada M, Matsui M, Kaji R, Nakashima K, Kuwano R, Takahashi S, Asada T, Akiyama H
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2012-07-15
• [Presentation] Methylene blue reduced tau phosphorylation and aggregation in P301L transgenic mice (2012)
  • Author(s): Hosokawa M, Arai T, Suzukake M, Yamashita M, Nonaka T, Hasegawa M, Kiyama H
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2012-07-15
• [Presentation] ALSとTDP-43の生化学 (2012)
  • Author(s): 長谷川成人, 野中隆, 辻浩史, 玉岡晃, 吉田眞理, 村山繁雄, Mann David, 新井哲明, 秋山治彦
  • Organizer: 第53回日本神経病理学会総会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2012-06-30
• [Presentation] 前頭側頭葉変性症の分子医学 (2011)
  • Author(s): 新井哲明
  • Organizer: 第30回日本認知症学会シンポジウム1「認知症のゲノム・遺伝学
  • Place of Presentation: 名古屋
  • Year and Date: 2011-11-11
• [Presentation] メチレンブルーによるリン酸化タウ蓄積抑制効果の検討 (2011)
  • Author(s): 細川雅人, 新井哲明, 野中隆, 山下万貴子, 鈴掛雅美, 辻浩史, 長谷川成人, 秋山治彦
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-11-11
• [Presentation] Histopathological analysis of progranulin knockout mice (2011)
  • Author(s): Arai T, Matsuwaki T, Hasegawa M, Akiyama H, Nonaka T, Hosokawa M, Takahashi S, Mizukami K, Asada T, Nishihara M
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-18
• [Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders (2011)
  • Author(s): Hosokawa M, Arai T, Nonaka T, Yamashita M, Tsuji H, Hasegawa M, Akiyama H
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-18
• [Presentation] 前頭側頭葉変性症の最新分類法–A new classification of frontotemporal lobar degeneration– (2011)
  • Author(s): 新井哲明, 朝田隆
  • Organizer: 第26回日本老年精神医学会
  • Place of Presentation: 東京 (企画講演I-2)
  • Year and Date: 2011-06-16
• [Presentation] FTLD-FUSの1剖検例 (2011)
  • Author(s): 新井哲明, 岩切雅彦, 水上勝義, 畑中公孝, 袖山紀子, 田中芳郎, 山形晃彦, 石井映美, 朝田隆
  • Organizer: 第52回日本神経病理学会総会学術研究会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-03
• [Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice (2011)
  • Author(s): Hosokawa H, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington, DC, USA
• [Presentation] 神経変性疾患における蛋白癌仮説 (2011)
  • Author(s): 長谷川成人, 野中隆，辻浩史，山下万貴子，増田雅美，玉岡晃，村山繁雄，新井哲明, 秋山治彦
  • Organizer: 第52回日本神経学会総会(招待講演)
  • Place of Presentation: 名古屋
• [Presentation] ニューロピルに認められるＦＵＳ陽性微細顆粒について (2011)
  • Author(s): 青木直哉, 東晋二, 小林禅, 細川雅人, 近藤ひろみ, 羽賀千恵, 泉山洋子, 都甲崇, 勝瀬大海, 内門大丈, 鈴木京子, 新井哲明, 長谷川成人, 平安良雄, 秋山治彦
  • Organizer: 第52回日本神経病理学会総会学術研究会
  • Place of Presentation: 京都
• [Presentation] Histopathological analysis of progranulin knockout mice. (2011)
  • Author(s): Arai T, Matsuwaki T, Hasegawa M, Akiyama H, Nonaka T, Hosokawa M, Takahashi S, Mizukami K, Asada T, Nishihara M
  • Organizer: Alzheimer’s Association International Conference 2011
  • Place of Presentation: パリ（フランス）
• [Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders. (2011)
  • Author(s): Hosokawa M, Arai T, Nonaka T, Yamashita M, Tsuji H, Hasegawa M, Akiyama H
  • Organizer: Alzheimer’s Association International Conference 2011
  • Place of Presentation: パリ（フランス）
• [Presentation] メチレンブルーによるリン酸化タウ蓄積抑制効果の検討 (2011)
  • Author(s): 細川雅人, 新井哲明, 野中隆, 山下万貴子, 鈴掛雅美, 辻浩史, 長谷川成人,秋山治彦
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京
• [Presentation] FTLD-TDPおよびALSに蓄積するTDP-43蛋白の凝集体構造に関する解析 (2011)
  • Author(s): 辻浩史, 野中隆, 新井哲明,山下万貴子, 亀谷富由樹, 細川雅人, 初田裕幸, 高尾昌樹, 村山繁雄, 齊藤祐子, 長谷川成人, 秋山治彦, Mann DMA, 詫間浩, 玉岡晃
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京
• [Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice. (2011)
  • Author(s): Hosokawa H, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
  • Organizer: Neuroscience 2011
  • Place of Presentation: ワシントン（アメリカ）
• [Presentation] 前頭側頭葉変性症の最新分類法 - A new classification of frontotemporal lobar degeneration - (2011)
  • Author(s): 新井哲明, 朝田隆
  • Organizer: 第26回日本老年精神医学会(招待講演)
  • Place of Presentation: 東京
• [Presentation] ALS/前頭側頭葉変性症の分子病態機序 (2011)
  • Author(s): 長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 秋山治彦
  • Organizer: 第28回日本医学会総会(招待講演)
  • Place of Presentation: 東京
• [Presentation] Accumulation of phosphorylated and cleaved TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. (2011)
  • Author(s): Arai T
  • Organizer: The First Bonn-Tsukuba Symposium in Medicine(招待講演)
  • Place of Presentation: 茨城
• [Presentation] 前頭側頭葉変性症の分子医学 (2011)
  • Author(s): 新井哲明
  • Organizer: 第30回日本認知症学会(招待講演)
  • Place of Presentation: 東京
• [Presentation] 細胞内異常蛋白質の伝播の可能性 (2011)
  • Author(s): 長谷川成人, 野中隆, 辻浩史, 増田雅美, 山下万貴子, 玉岡晃, Mann David, 村山繁雄, 新井哲明, 秋山治彦
  • Organizer: 第30回日本認知症学会(招待講演)
  • Place of Presentation: 東京
• [Presentation] Prion-like properties of pathological TDP-43 in diseased brains.
  • Author(s): 野中隆, 鈴掛雅美, 新井哲明, 赤津裕泰, 小尾智一, 吉田眞理, 村山繁雄, Mann D, 秋山治彦, 長谷川成人
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
• [Presentation] tangle-predominant dementiaの側座核におけ病理学的検討.
  • Author(s): 河上緒, 長谷川成人, 新井哲明, 青木直哉, 勝瀬大海, 東晋二, 大島健一, 新里和弘, 近藤ひろみ, 羽賀千恵, 下村洋子, 山下万貴子, 鈴木京子, 平安良雄, 秋山治彦
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
• [Presentation] 延髄呼吸中枢病変を認めた進行性核上性麻痺の１剖検例
  • Author(s): 小林禅, 赤座実穂, 石原正一郎, 沼沢祥行, 富満弘之, 鵜浦康司, 稲留征典, 新井哲明, 新谷周三
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
• [Presentation] 茨城県内２地域における認知症疫学調査の比較
  • Author(s): 池嶋千秋, 吉村敦子, 久永明人, 根本清貴, 高橋晶, 文鐘玉, 井上操, 新井哲明, 朝田隆
  • Organizer: 第28回日本老年精神医学会
  • Place of Presentation: 大阪
• [Presentation] TDP-43陽性病変のtype分類の意義と限界
  • Author(s): 新井哲明
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] FTLDの概念
  • Author(s): 新井哲明
  • Organizer: 第14回若年認知症研究会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] タウオパチー病理変化の基礎
  • Author(s): 新井哲明
  • Organizer: 第32回日本認知症学会学術集会
  • Place of Presentation: 松本
  • Invited
• [Presentation] レビー小体型認知症とパーキンソン病における延髄のαシヌクレイン陽性構造の比較検討.
  • Author(s): 高橋晶, 新井哲明, 水上勝義, 近藤ひろみ, 大島健一, 新里和弘, 細川雅人, 秋山治彦, 朝田隆
  • Organizer: 第53回日本神経病理学会総会学術集会
  • Place of Presentation: 新潟
• [Presentation] 進行性失語が前景に立った運動ニューロン疾患を伴う前頭側頭型認知症の二剖検例.
  • Author(s): 河上緒, 東晋二, 青木直哉, 新里和弘, 大島健一, 安野みどり, 羽賀千恵, 下村洋子, 鈴木京子, 勝瀬大海, 都甲崇, 小林禅, 辻浩史, 玉岡晃, 長谷川成人, 新井哲明, 土谷邦秋, 平安良雄, 秋山治彦
  • Organizer: 第53回日本神経病理学会総会学術集会
  • Place of Presentation: 新潟
• [Presentation] ALSとTDP-43の生化学.
  • Author(s): 長谷川成人, 野中隆, 辻浩史, 玉岡晃, 吉田眞理, 村山繁雄, Mann David, 新井哲明, 秋山治彦
  • Organizer: 第53回日本神経病理学会総会学術集会
  • Place of Presentation: 新潟
  • Invited
• [Presentation] Screening of the SOD1, TARDBP and FUS mutations and the pathological studies in Japanese cases with familial and sporadic amyotrophic lateral sclerosis.
  • Author(s): Arai T, Arai M, Itokawa M, Yoshida M, Tamaoka A, Kobayashi Z, Hosokawa M, Hasegawa M, Nonaka T, Tsuji H, Yamada M, Matsui M, Kaji R, Nakashima K, Kuwano R, Takahashi S, Asada T, Akiyama H
  • Organizer: Alzheimer’s Association International Conference 2012
  • Place of Presentation: Vancouver, Canada
• [Presentation] Methylene blue reduced tau phosphorylation and aggregation in P301L transgenic mice.
  • Author(s): Hosokawa M, Arai T, Suzukake M, Yamashita M, Nonaka T, Hasegawa M, Akiyama H
  • Organizer: Alzheimer’s Association International Conference 2012
  • Place of Presentation: Vancouver, Canada
• [Presentation] Three autopsy cases of FTD-MND with progressive aphasia.
  • Author(s): Kawakami I, Higashi S, Aoki N, Niizto K, Ohshima K, Katsuse O, Togo T, Kobayashi Z, Hosokawa M, Tsuji H, Tamaoka A, Hasegawa M, Arai T, Tsuchiya K, Hirayasu Y, Akiyama H
  • Organizer: The 8th International Conference on Frontotemporal Dementias
  • Place of Presentation: Manchester, UK
• [Presentation] Intracellular seeding model reproduces characteristic features of affected neurons in TDP-43 proteinopathy.
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Yoshida M, Murayama S, Man DMA, Akiyama H, Hasegawa M
  • Organizer: The 8th International Conference on Frontotemporal Dementias
  • Place of Presentation: Manchester, UK
• [Presentation] 老年期発症の幻覚妄想を認め、辺縁系に高度タウ病変を認めた3剖検例.
  • Author(s): 河上緒, 新井哲明, 池田研二, 大島健一, 新里和弘, 東晋二, 青木直哉, 水上勝義, 平安良雄, 秋山治彦
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば市
• [Presentation] レビー小体型認知症とパーキンソン病における延髄のαシヌクレイン陽性構造の比較検討.
  • Author(s): 高橋晶, 新井哲明, 水上勝義, 近藤ひろみ, 大島健一, 新里和弘, 細川雅人, 秋山治彦, 朝田隆
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば市
• [Presentation] シード依存的な細胞内TDP-43蓄積による細胞死の誘導.
  • Author(s): 野中隆, 鈴掛(増田)雅美, 新井哲明, 吉田眞理, 村山繁雄, Mann David, 秋山治彦, 長谷川成人
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば市
• [Presentation] 中枢性呼吸障害の存在が示唆された進行性核上性麻痺の1剖検例.
  • Author(s): 小林禅, 赤座実穂, 石原正一郎, 沼沢祥行, 富満弘之, 鵜浦康司, 稲留征典, 新井哲明, 新谷周三
  • Organizer: 第592回日本内科学会関東地方会
  • Place of Presentation: 東京
• [Presentation] 前頭側頭葉変性症の分子病態とそれに基づく診療の進歩.
  • Author(s): 新井哲明
  • Organizer: 第７回日本認知症学会教育セミナー
  • Place of Presentation: 東京
  • Invited
• [Presentation] 前頭側頭葉変性症の分子病理.
  • Author(s): 新井哲明
  • Organizer: 第１９回九州老年期認知症研究会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 前頭側頭葉変性症.
  • Author(s): 新井哲明
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば市
  • Invited
• [Presentation] Accumulation of phosphorylated and cleaved TDP-43 in neurodegenerative disorders.
  • Author(s): Arai T
  • Organizer: Seoul Neuropathology Forum
  • Place of Presentation: Seoul
  • Invited
• [Book] ICD-10精神科診断ガイドブック (2013)
  • Author(s): 新井哲明
  • Publisher: 中山書店
• [Book] 抗認知症薬および脳循環・代謝改善薬,精神・神経の治療薬事典 (2013)
  • Author(s): 新井哲明
  • Publisher: 総合医学社
• [Book] 精神・神経の治療薬事典 (2013)
  • Author(s): 新井哲明
  • Publisher: 総合医学社
• [Book] アルツハイマー病治療薬の臨床、実践治療薬 (2012)
  • Author(s): 新井哲明
  • Publisher: 金芳堂
• [Book] 実践治療薬 (2012)
  • Author(s): 新井哲明
  • Publisher: 金芳堂
• [Book] 認知症診療の実践テクニック-患者・家族にどう向き合うか.非アルツハイマー型認知症とは (2011)
  • Author(s): 横田修, 根本清貴, 新井哲明
  • Publisher: 医学書院
• [Book] 筋萎縮性側索硬化症(ALS)マウス、seriesモデル動物利用マニュアル、疾患モデルの作製と利用、脳・神経疾患 (2011)
  • Author(s): 野中隆, 新井哲明, 長谷川成人
  • Publisher: LIFE-SCIENCE INFORMATION CENTER
• [Book] 認知症の薬物療法 (2011)
  • Author(s): 新井哲明
  • Publisher: 新興医学出版社
• [Book] 認知症診療の実践テクニック－患者・家族にどう向き合うか (2011)
  • Author(s): 横田修, 根本清貴, 新井哲明
  • Publisher: 医学書院
• [Book] seriesモデル動物利用マニュアル (2011)
  • Author(s): 野中隆, 新井哲明, 長谷川成人
  • Publisher: LIFE-SCIENCE INFORMATION CENTER