| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
TDP-43, FUS and tau are the major components of the neuronal and glial inclusions in a variety of neurodegenerative disorders. The distributions of these proteins were related to the clinical features in most disorders. The combined accumulation of these proteins frequently occurred in many of neurodegenerative disorders, including frontotemporal lobar degeneration, motor neuron diseases and diffuse neurofibrillary tangles with calcification. Methylene blue reduced tau accumulation in mice harboring tau gene mutation, suggesting that inhibition of tau aggregation by it may have potential as a drug candidate for the treatment of tauopathy. The results of the present study suggest developing the methods to detect each protein in biological fluids may be important for the diagnosis and the disease modifying therapy for the diseases.
|
