The effect of insulin-resistance on increasing poor response to agents in the patients with treatment-resistance depressive disorder

• Project/Area Number: 23591695
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: NARITA Kosuke 群馬大学, 医学部附属病院, 講師 (70345677)
• Co-Investigator(Kenkyū-buntansha): FUKUDA Masato 群馬大学, 大学院医学系研究科, 教授 (20221533) ; 三國 雅彦 群馬大学, その他部局等, 名誉教授 (00125353)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 治療抵抗性気分障害 / インスリン抵抗性 / 気分障害 / 脳形態画像 / MRI / VBM / ASL

Research Abstract

In this study, we aimed to investigate physiological mechanisms regarding the effect of insulin-resistance on increasing poor response to agents in the patients with treatment-resistance depressive disorder, by Voxel-based-morphometry (VBM), Intimal-media thickness ( IMT) and flow-mediated vasodialation (FMD).

Research Products

• [Journal Article] Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation : a near-infrared spectroscopy study (2013)
  • Author(s): Takei Y, Suda M, Aoyama Y, Yamaguchi M, Sakurai N, Narita K, Fukuda M, Mikuni M
  • Journal Title: J Psychiatr Res Volume: 47(11) Pages: 1581-9
• [Journal Article] Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation: a near-infrared spectroscopy study (2013)
  • Author(s): Takei Y, Suda M, Aoyama Y, Yamaguchi M, Sakurai N, Narita K, Fukuda M, Mikuni M
  • Journal Title: J Psychiat Res Volume: 47 Issue: 11 Pages: 1581-9
  • DOI: 10.1016/j.jpsychires.2013.07.029
  • Peer Reviewed
• [Journal Article] Effects of antidepressants and mood stabilizers on serum levels of adiponectin. (2012)
  • Author(s): Omata N, Murata T, Narita K, Maruoka N, Mitsuya H, Mita K, Nishimoto T, Sato M, Wada Y.
  • Journal Title: Neuro Endocrinol Lett. Volume: 33 Pages: 1-2
  • Peer Reviewed
• [Journal Article] Associations among parenting experiences during childhood and adolescence, hypothalamus-pituitary-adrenal axis hypoactivity, and hippocampal gray matter volume reduction in young adults (2012)
  • Author(s): Narita K, Fujihara K, Takei Y, Suda M, Aoyama Y, Uehara T, Majima T, Kosaka H, Amanuma M, Fukuda M, Mikuni M
  • Journal Title: Hum Brain Mapp Volume: 33 Issue: 9 Pages: 2211-2223
  • DOI: 10.1002/hbm.21354
  • Peer Reviewed
• [Journal Article] Associations among parenting experiences during childhood and adolescence, hypothalamus-pituitary-adrenal axis hypoactivity, and hippocampal gray matter volume reduction in young adults. (2012)
  • Author(s): Narita K, Fujihara K, Takei Y, Suda M, Aoyama Y, Uehara T, Majima T, Kosaka H, Amanuma M, Fukuda M, Mikuni M.
  • Journal Title: Hum Brain Mapp Volume: In press
  • Peer Reviewed