Association between MicroRNA Dysregulation and Oxidative Damage in Brains with Alzheimer's Disease
| Project/Area Number |
23591698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 認知症 / アルツハイマー病 / 加齢脳 / 酸化ストレス / RNA / ミトコンドリアDNA / 認知機能障害 / アメリカ合衆国 |
|---|
| Research Abstract |
An in situ approach in the cerebral cortex of postmortem brains revealed that levels of oxidative damage to nucleic acids in neurons increased during aging and remarkably increased at the stage of very mild Alzheimer's disease. The neuronal nucleic acids oxidation in aging was significantly associated with mitochondrial DNA deletion, and both of them were regarded as crucial alterations in the prodromal stage of neurodegeneration.In this study, however, specific reactions of microRNA were hardly detected in postmortem brains, which suggested requirements of strictly controlled conditions in the processing of the brains to investigate microRNA in situ.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Accumulation of intraneuronal amyloid-β is common in normal brain2014
Author(s)
Blair JA, Siedlak S, Wolfram J, Nunomura A, Castellani R, Ferreira S, Klein W, Wang Y, Casadesus G, Smith M, Perry G, Zhu X, Lee H
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Journal Title
Current Alzheimer Research
Volume: 11
Issue: 4
Pages: 317-324
DOI
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Peer Reviewed
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[Journal Article] Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links2013
Author(s)
Perry EA, Castellani RJ, Moreira PI, Nunomura A, Lui Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G
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Journal Title
Free Radical Research
Volume: 47巻
Pages: 507-510
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Peer Reviewed
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[Presentation] Alzheimer’s-like alterations in structural and functional brain imaging are associated with depressive symptoms and memory impairment in elderly depression2013
Author(s)
Tamaoki T, Nunomura A, Tamai K, Kitahara Y, Yasuda K, Uemura T, Matsushita Y, Ishiguro H, Ishigame K, Araki T, Motohashi N
Organizer
11th World Congress of Biological Psychiatry
Place of Presentation
Kyoto International Conference Center, Kyoto, Japan
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[Book] Thinking outside the box in Alzheimer disease treatment、In : Development of Therapeutic Agents2011
Author(s)
Castellani RJ, Marlatt MW, Nunomura A, Moreira PI, Lee HG, Casadesus G, Zhu X, Perry G, Smith MA (Gad SC (Ed))
Publisher
John Wiley & Sons, Inc.、Hoboken, NJ
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[Book] Oxidative stress in Alzheimer's disease : a critical appraisal of the causes and the consequences、In : Studies on Experimental Models : Oxidative Stress in Applied Basic Research and Clinical Practice, Part 32011
Author(s)
Chang J, Siedlak S, Moreira P, Nunomura A, Castellani RJ, Smith MA, Zhu X, Perry G, Casadesus G (Basu S, Wiklund L (Eds))
Publisher
Springer Science+Business Media LLC、New York
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