| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
The aim of this study is to clarify the pathogenesis of Schizophrenic disorder from the point of view of neuropathological approach. In this period, it has been detected as achievement as follows: 1) Dopaminergic neuronal impairment has been detected in the frontal cortex of genetic modified model animals (mouse) of Schizophrenia. 2) Similarly, it has been detected that the number of GABAergic neurons was reduced in the frontal cortex of the model animals. 3) The vulnerability of the brain tissue in Heschl's gyrus of schizophrenic disease has been detected by the morphometric analysis for the neuropathologocal specimens of post mortem human brain. 4) In the cortex of same area, the decrease of myelin protein was observed. These phenomena may be thought to relate to the volume reduction by neuroimeging observation in this gyrus.
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