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A prospective study of the pathogenesis of Premenstrual Mood Disorder

Research Project

Project/Area Number 23591702
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionMie University

Principal Investigator

OKANO TADAHARU  三重大学, 保健管理センター, 教授 (90169128)

Co-Investigator(Kenkyū-buntansha) 杉山 隆  愛媛大学, 医学部, 教授 (10263005)
高山 恵理奈  三重大学, 医学部附属病院, 医員 (90589847)
Project Period (FY) 2011-04-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords月経前気分不快障害 / 分娩 / 好発時期 / 危険因子 / マタニティー・ブルーズ / マタニティブルーズ / 産後うつ病 / postnatal depression / PMDD
Outline of Final Research Achievements

Objective: The aim of this study is to examine the prevalence of PMS and PMDD after delivery. Methods: A longitudinal survey was done at Mie University Hospital. Of 218 subjects approached, 200 pregnant women were finally analyzed for sociodemographic data, menstrual history, and premenstrual symptoms. Results: The prevalence of PMDD was 7.3 % (9/124) and moderate to severe PMS was 8.1% at one year after delivery. Only two of PMDD women had previous histories of PMDD episode. Women with PMMD group showed significantly higher HADS-A scores and HADS-D scores and EPDS scores. Women with histories of PMS group showed significantly higher Stein’s scores and EPDS scores in 5th day postpartum. Conclusions: Prevalence rate of PMDD at one year after delivery is similar to other studies from Western countries. Most of the instances of PMDD were the first episode after delivery. There must be some mechanism suggested for the first onset of PMDD according to the change of hormonal mechanism.

Report

(7 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2017 2015 2011

All Journal Article (4 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Maternity bluesの病態と社会心理および生物学的関連性2015

    • Author(s)
      岡野禎冶
    • Journal Title

      臨床精神薬理

      Volume: 18 Pages: 415-421

    • Related Report
      2015 Research-status Report
  • [Journal Article] 周産期におけるうつ病の危険因子と予防2015

    • Author(s)
      岡野禎冶
    • Journal Title

      臨床精神医学

      Volume: 44 Pages: 527-533

    • Related Report
      2015 Research-status Report 2014 Research-status Report
  • [Journal Article] 産褥期のうつ病の研究概観2011

    • Author(s)
      岡野禎治
    • Journal Title

      看護研究

      Volume: 44 Pages: 438-445

    • Related Report
      2011 Research-status Report
  • [Journal Article] 夢幻・錯乱状態2011

    • Author(s)
      岡野禎治
    • Journal Title

      精神科治療学

      Volume: 27 Pages: 408-409

    • Related Report
      2011 Research-status Report
  • [Presentation] A Prospective study for incidence of premenstrual dysphoric disorder (PMDD) from late pregnancy to one year after delivery.2017

    • Author(s)
      Tadaharu Okano, Erina Takayama, Kaori Namekata & Takashi Sugiyama
    • Organizer
      7th World Congress on Women's Mental Health
    • Place of Presentation
      Dublin
    • Year and Date
      2017-03-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 周産期精神医学、過去、現在、未来2015

    • Author(s)
      岡野禎治
    • Organizer
      日本周産期メンタルヘルス学会
    • Place of Presentation
      自治医科大学(栃木県下野市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] A study of the relationship between premenstrual dysphoric disorder and maternal psychiatric state in postpartum period.2015

    • Author(s)
      Tadaharu Okano
    • Organizer
      第4回Invernational Congress of Dual disorder
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-04-17 – 2015-04-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 産褥精神病再考-診断基準と分類-2011

    • Author(s)
      岡野禎治
    • Organizer
      第3回「急性精神病」フォーラム(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] 脳とこころのプライマリケア第7巻食事と性2011

    • Author(s)
      岡野禎治
    • Total Pages
      300
    • Publisher
      株式会社シナジー
    • Related Report
      2011 Research-status Report
  • [Book] マタニティサイクルとメンタルヘルス2011

    • Author(s)
      岡野禎治
    • Total Pages
      164
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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