Development of therapeutic agents for Alzheimer's disease focused by a new modulator of gamma-secretase complex
Project/Area Number |
23591705
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Osaka University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YAMADA Kohei 浜松医科大学, 子どものこころの発達研究センター, 講師 (50588879)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | アルツハイマー病 / プレセニリン / ガンマセクレターゼ / アミロイド / 脳・神経 / 認知症 / ミトコンドリア / γセクレターゼ |
Outline of Final Research Achievements |
A-beta is known as a most important molecule of Alzheimer's disease (AD) pathogenesis. We tried to identify a new modulator of gamma-secretase which is the final cutting enzyme of the A-beta production using in vivo crosslink method. As a result, unknown molecule GL was identified as a immunoprecipitant with both presnilin-1 and aph-1 antibodies. It is indicated that GL binds to other gamma-secretase components, and attenuation of GL expression by siRNA decrease A-beta production. These results suggest that regulation of GL expression might be a new therapeutic target for AD prevention or inhibition of its development.
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Report
(5 results)
Research Products
(6 results)
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[Journal Article] N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism.2014
Author(s)
1.Iwata K, Matsuzaki H, Tachibana T, Ohno K, Yoshimura S, Takamura H, Yamada K, Matsuzaki S, Nakamura K, Tsuchiya KJ, Matsumoto K, Tsujii M, Sugiyama T, Katayama T, Mori N
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Journal Title
Molecular Autism
Volume: 5(33)
Issue: 1
Pages: 2040-2392
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lack of dopaminergic inputs elongates the primary cilia of striatal neurons.2014
Author(s)
2.Miyoshi K, Kasahara K, Murakami S, Takeshima M, Kumamoto N, Sato A, Miyazaki I, Matsuzaki S, Sasaoka T, Katayama T, Asanuma M.
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Journal Title
PLoS One
Volume: 9(5)
Issue: 5
Pages: e97918-e97918
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration2013
Author(s)
Magome T, Hattori T, Taniguchi M, Ishikawa T, Miyata S, Yamada K, Takamura H, Matsuzaki S, Ito A, Tohyama M, Katayama T
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Journal Title
Neurochemistry International
Volume: 63
Issue: 6
Pages: 561-569
DOI
Related Report
Peer Reviewed
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[Journal Article] DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices.2013
Author(s)
Koyama Y, Hattori T, Shimizu S, Taniguchi M, Yamada K, Takamura H, Kumamoto N, Matsuzaki S, Ito A, Katayama T, Tohyama M.
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Journal Title
J Chem Neuroanat.
Volume: 53
Pages: 1-10
DOI
Related Report
Peer Reviewed
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