A study of treatment strategies for obsessive-compulsive disorder by using cognitive performance and functional neuroimagings

• Project/Area Number: 23591709
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokushima
• Principal Investigator: SUMITANI Satsuki 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (90346594)
• Co-Investigator(Kenkyū-buntansha): HARADA Masafumi 徳島大学, 大学院ヘルスバイオサイエンス, 教授 (20228654) ; TOMOTAKE Masahito 徳島大学, 大学院ヘルスバイオサイエンス, 教授 (50294682)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 強迫性障害 / 認知機能 / 機能画像 / 前頭葉 / 基底核 / NIRS / MRS / 前頭葉機能 / GABA / 脳血流 / Stroop Test / グルタミン酸

Research Abstract

We studied to find strategies for obsessive compulsive disorder(OCD) by using cognitive performance and functional neuroimagings. We found abnormalities of metabolites of right basal ganglia of OCD patients by using 3 tesla proton magnetic resonance spectroscopy (MRS). Moreover we found a significantly lower cognitive performance and a hypofrontality of OCD patients by using multichannel NIRS compared to control group. It is suggested that we might choose strategies for OCD patients who have different biological feature individually.

Research Products

• [Journal Article] Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia (2014)
  • Author(s): Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T
  • Journal Title: Schizophr Bull Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Measuring quality of sleep and autonomic nervous function in healthy Japanese women (2014)
  • Author(s): Sato M, Yasuhara Y, Tanioka T, Iwasa Y, Miyake M, Yasui T, Tomotake M, Kobayashi H, Locsin RC
  • Journal Title: Neuropsychiatr Dis Treat Volume: 10 Pages: 89-96
  • Peer Reviewed
• [Journal Article] Psychiatric symptoms in a patient with isolated adrenocorticotropin deficiency: case report and literature review (2014)
  • Author(s): Morigaki Y, Iga JI, Kameoka N, Sumitani S, Ohmori T
  • Journal Title: Gen Hosp Psychiatry Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Preliminary Observation of Dynamic Changes in Alcohol Concentration in the Human Brain with Proton Magnetic Resonance Spectroscopy on a 3T MR Instrument (2013)
  • Author(s): Kubo H, Harada M, Sakama M, Matsuda T, Otsuka H
  • Journal Title: Magn Reson Med Sci Volume: 12(3) Pages: 235-240
  • NAID: 10031201762
  • Peer Reviewed
• [Journal Article] Successful treatment of stiff person syndrome with sequential use of tacrolimus (2013)
  • Author(s): Nakane S, Fujita K, Shibuta Y, Matsui N, Harada M, Urushihara R, Nishida Y, Izumi Y, Kaji R
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 84(10) Pages: 1177-1180
  • Peer Reviewed
• [Journal Article] A proton magnetic resonance spectroscopic study in autism spectrum disorders : amygdala and orbito-frontal cortex (2013)
  • Author(s): Mori K, Toda Y, Ito H, Mori T, Goji A, Fujii E, Miyazaki M, Harada M, Kagami S
  • Journal Title: Brain Dev Volume: 35(2) Pages: 139-145
  • Peer Reviewed
• [Journal Article] Factors associated with discharge of long-term inpatients with schizophrenia in Japan : a retrospective study (2013)
  • Author(s): Tanioka T, Chiba S, Onishi Y, Kataoka M, Kawamura A, Tomotake M, Williams CL, Yasuhara Y, Mifune K
  • Journal Title: Issues Ment Health Nurs Volume: 34 Pages: 256-264
  • Peer Reviewed
• [Journal Article] 精神科領域における最近のMRIの進歩高磁場MRSの精神疾患への応用 (2013)
  • Author(s): 住谷さつき
  • Journal Title: 精神科 Volume: 22(4) Pages: 394-400
• [Journal Article] 多チャンネル近赤外線スペクトロスコピーが示す広汎性発達障害の表情処理過程における前頭前野の賦活反応性の低下 (2013)
  • Author(s): 中土井芳弘, 渡部幸奈, 細川麻衣, 住谷さつき, 大森哲郎
  • Journal Title: 精神神経学雑誌 Volume: 115(3) Pages: 237-244
  • NAID: 10031195407
• [Journal Article] Multi-channel near-infrared spectroscopy shows reduced activation in the prefrontal cortex during facial expression processing in pervasive developmental disorder (2013)
  • Author(s): Nakadoi Y, Watabe Y, Hosokawa M, Sumitani S, Ohmori T.
  • Journal Title: Seishin Shinkeigaku Zasshi Volume: 115 Pages: 237-234
• [Journal Article] Factors associated with discharge of long-term inpatients with schizophrenia in Japan: a retrospective study. (2013)
  • Author(s): Tanioka T, Chiba S, Onishi Y, Kataoka M, Kawamura A, Tomotake M, Williams CL, Yasuhara Y, Mifune K.
  • Journal Title: Issues Ment Health Nurs Volume: 34 Pages: 256-264
  • Peer Reviewed
• [Journal Article] Preliminary observation of dynamic changes in alcohol concentration in the human brain with proton magnetic resonance spectroscopy on a 3T MR instrumen (2013)
  • Author(s): Kubo H, Harada M, Sakama M, Matsuda T, Otsuka H
  • Journal Title: Magn Reson Med Sci Volume: 12 Pages: 235-240
  • Peer Reviewed
• [Journal Article] 高磁場MRSの精神疾患への応用 (2013)
  • Author(s): 住谷さつき
  • Journal Title: 精神科 Volume: 22 Pages: 394-400
• [Journal Article] 広汎性発達障害における多チャンネル近赤外線スペクトロスコピーを用いた表情処理過程 (2013)
  • Author(s): 中土井芳弘 渡部幸奈 細川麻衣 住谷さつき 大森哲郎
  • Journal Title: 日本生物学的精神医学会誌 Volume: 24 Pages: 235-240
  • NAID: 130005395498
• [Journal Article] Multi-channel near-infrared spectroscopy shows reduced activation in the prefrontal cortex during facial expression processing in pervasive developmental disorder (2012)
  • Author(s): Nakadoi Y, Sumitani S, Watanabe Y, Akiyama M, Yamashita N, Ohmori T
  • Journal Title: Psychiatry Clin Neurosci Volume: 66(1) Pages: 26-33
  • Peer Reviewed
• [Journal Article] Multi-channel near-infrared spectroscopy reveals reduced prefrontal activation in schizophrenia patients during performance of the kana Stroop task (2012)
  • Author(s): Taniguchi K, Sumitani S, Watanabe Y, Akiyama M, Ohmori T
  • Journal Title: J Med Invest Volume: 59(1-2) Pages: 45-52
  • NAID: 130004465270
  • Peer Reviewed
• [Journal Article] Preliminary observations and diagnostic value of lipid peak in ovarian thecomas/fibrothecomas using in vivo proton MR spectroscopy at 3T (2012)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M
  • Journal Title: J Magn Reson Imaging Volume: 36(4) Pages: 907-911
  • Peer Reviewed
• [Journal Article] Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex (2012)
  • Author(s): Mori K, Mori T, Toda Y, Fujii E, Miyazaki M, Harada M, Kagami S
  • Journal Title: Brain Dev Volume: 34(6) Pages: 478-486
  • Peer Reviewed
• [Journal Article] Quality of life and its predictors in people with schizophrenia (2012)
  • Author(s): Tomotake M
  • Journal Title: J Med Invest Volume: 58 Pages: 167-174
  • NAID: 130004822653
  • Peer Reviewed
• [Journal Article] Clinical correlates associated with cognitive dysfunction in people with schizophrenia (2012)
  • Author(s): Tanaka T, Tomotake M, Ueoka Y, Kaneda Y, Taniguchi K, Nakataki M, Numata S, Tayoshi S, Yamauchi K, Sumitani S, Ohmori T, Ueno S, Ohmori T
  • Journal Title: Psychiatry Clin Neurosci Volume: 66 Pages: 491-498
  • Peer Reviewed
• [Journal Article] 強迫性障害の神経生物学的基盤 (2012)
  • Author(s): 住谷さつき
  • Journal Title: 臨床精神医学 Volume: 41(1) Pages: 13-20
• [Journal Article] 精神神経疾患領域におけるMR spectroscopy (2012)
  • Author(s): 住谷さつき
  • Journal Title: 画像診断 Volume: 32(6) Pages: 500-506
• [Journal Article] 自閉症スペクトラムと青年成人期精神障害の接点, 自閉症スペクトラムと強迫性障害 (2012)
  • Author(s): 住谷さつき
  • Journal Title: 児童青年精神医学とその近接領域 Volume: 53(4) Pages: 496-500
• [Journal Article] メンタルヘルスと栄養認知症と栄養 (2012)
  • Author(s): 住谷さつき
  • Journal Title: 四国医学雑誌 Volume: 68(1,2) Pages: 9-12
• [Journal Article] 自閉症スペクトラムと強迫性障害 (2012)
  • Author(s): 住谷さつき
  • Journal Title: 児童青年精神医学とその近接領域 Volume: 53(4) Pages: 496-500
  • NAID: 10031128255
• [Journal Article] Multi-channel near-infrared spectroscopy reveals reduced activation in the prefrontal cortex during the facial expression processing in patients with pervasive developmental disorders (2012)
  • Author(s): Nakadoi Y, Sumitani S, Watanabe Y, Akiyama M, Yamashita N, Ohmori T
  • Journal Title: Psychiatry Clin Neurosci Volume: 66(1) Issue: 1 Pages: 26-33
  • DOI: 10.1111/j.1440-1819.2011.02290.x
  • Peer Reviewed
• [Journal Article] Evaluation of the GABAergic nervous system in autistic brain: (123)I-iomazenil SPECT study (2012)
  • Author(s): Mori T, et al
  • Journal Title: Brain Dev Volume: 34 Issue: 8 Pages: 648-654
  • DOI: 10.1016/j.braindev.2011.10.007
  • Peer Reviewed
• [Journal Article] Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex (2012)
  • Author(s): Mori K, et al
  • Journal Title: Brain Dev Volume: 34 Issue: 6 Pages: 478-486
  • DOI: 10.1016/j.braindev.2011.09.001
  • Peer Reviewed
• [Journal Article] Measurement of variation in the human cerebral GABA level by in vivo MEGA-editing proton MR spectroscopy using a clinical 3 T instrument and its dependence on brain region and the female menstrual cycle (2011)
  • Author(s): Harada M, Kubo H, Nose A, Nishitani H, Matsuda T
  • Journal Title: Hum Brain Mapp Volume: 32(5) Pages: 828-833
  • Peer Reviewed
• [Journal Article] Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument (2011)
  • Author(s): Harada M, Taki MM, Nose A, Kubo H, Mori K, Nishitani H, Matsuda T
  • Journal Title: J Autism Dev Disord Volume: 41(4) Pages: 447-454
  • Peer Reviewed
• [Journal Article] Criterion and construct validity of the CogState Schizophrenia Battery in Japanese patients with schizophrenia (2011)
  • Author(s): Yoshida T, Suga M, Arima K, Muranaka Y, Tanaka T, Eguchi S, Lin C, Yoshida S, Ishikawa M, Higuchi Y, Seo T, Ueoka Y, Tomotake M, Kaneda Y, Darby D, Maruff P, Iyo M, Kasai K, Higuchi T, Sumiyoshi T, Ohmori T, Takahashi K, Hashimoto K
  • Journal Title: PLoS One Volume: Vol.6 Issue: 5 Pages: e20469-e20469
  • DOI: 10.1371/journal.pone.0020469
  • Peer Reviewed
• [Journal Article] Quality of life and cognitive dysfunction in people with schizophrenia (2011)
  • Author(s): Ueoka Y, Tomotake M, Tanaka T, Kaneda Y, Taniguchi K, Nakataki M, Numata S, Tayoshi S, Yamauchi K, Sumitani S, Ohmori T, Ueno S, Ohmori T
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 15 ; 35(1) Issue: 1 Pages: 53-9
  • DOI: 10.1016/j.pnpbp.2010.08.018
  • Peer Reviewed
• [Journal Article] Quality of life and its predictors in people with schizophrenia (2011)
  • Author(s): Tomotake M
  • Journal Title: The Journal of Medical Investigation Volume: 58 Issue: 3,4 Pages: 167-174
  • DOI: 10.2152/jmi.58.167
  • NAID: 130004822653
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed
• [Journal Article] Preliminary observations and clinical value of N-acetyl resonances in ovarian tumours using in-vivo proton MR spectroscopy at 3T. (2011)
  • Author(s): Takeuchi M, et al.
  • Journal Title: Eur Radiol. Volume: Dec;21(12) Issue: 12 Pages: 2640-6
  • DOI: 10.1007/s00330-011-2215-2
  • Peer Reviewed
• [Journal Article] Transient left temporal lobe lesion in Menkes disease may influence the generation of tonic spasms. (2011)
  • Author(s): Ito H, et al.
  • Journal Title: Brain Dev. Volume: Apr;33(4) Issue: 4 Pages: 345-8
  • DOI: 10.1016/j.braindev.2010.05.009
  • Peer Reviewed
• [Presentation] Development of a new motivational workbook for the treatment of anorexia nervosa (2013)
  • Author(s): M Tomotake, Y Nakadoi, S Chiba M Kataoka
  • Organizer: 15th International Congress of ESCAP, Convention Center Dubrin
  • Place of Presentation: Dubrin, Ireland
• [Presentation] Relation between disordered eating, sense of trust and perceived parenting in young women (2013)
  • Author(s): M Tomotake, S Chiba, M Kataoka, N Nishio H Hirano, C Imaizumi, A Suemasa A Tokubo Y Nakadoi
  • Organizer: 15th International Congress of ESCAP. Convention Center Dubrin
  • Place of Presentation: Dubrin, Ireland
• [Presentation] Clinical features and response to pharmacotherapy in patients with obsessive-compulsive disorder (2013)
  • Author(s): S.Sumitani, T.Ohmori
  • Organizer: 11^<th> World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Japan)
• [Presentation] Structural brain asymmetry in obsessive-compulsive disorder (2013)
  • Author(s): M.Nakataki, S.Sumitani, H. Kubo, S.Numata, J.Iga, S.Watanabe, M.Kinoshita, M.Harada, T.Ohmori
  • Organizer: 11^<th> World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Japan)
• [Presentation] Clinical features and response to pharmacotherapy in patients with obsessive-compulsive disorder (2013)
  • Author(s): S.Sumitani, T.Ohmori
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto International Conference Center, Kyoto
• [Presentation] Structural brain asymmetry in obsessive-compulsive disorder (2013)
  • Author(s): M.Nakataki, S.Sumitani, H. Kubo, S.Numata, J.Iga, S.Watanabe, M.Kinoshita, M.Harada, T.Ohmori
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto International Conference Center, Kyoto
• [Presentation] Zarit介護負担尺度を用いた高齢者の介護負担度に影響を与える要因の検討 (2012)
  • Author(s): 住谷さつき, 亀岡尚美, 細尾綾子, 亀沖彩乃, 大森哲郎
  • Organizer: 第32回日本精神科診断学会
  • Place of Presentation: カルチャーリゾートフェストーネ(沖縄県)
  • Year and Date: 2012-11-23
• [Presentation] 仮名と漢字における認知処理過程の差異-NIRSを用いた検討- (2012)
  • Author(s): 住谷さつき, 渡部幸奈, 細川麻衣, 大森哲郎
  • Organizer: 第12回精神疾患と認知機能研究会
  • Place of Presentation: 海運クラブ(東京都)
  • Year and Date: 2012-11-10
• [Presentation] メンタルヘルスと栄養 (2012)
  • Author(s): 住谷さつき
  • Organizer: 第244回徳島医学会学術集会
  • Place of Presentation: 長井記念ホール(徳島県) (シンポジウム)
  • Year and Date: 2012-02-12
• [Presentation] Caudate asymmetry in obesessive compulsive disorder: A voxel based morphometry study. (2012)
  • Author(s): M.Nakataki
  • Organizer: 28th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: The Stockholm Convention and Exhibition Centre, Stockholmsm&auml;ssan（Stockholm,Sweden）
• [Presentation] 自閉症スペクトラムと青年成人期精神障害の接点, 自閉症スペクトラムと強迫性障害 (2011)
  • Author(s): 住谷さつき
  • Organizer: 第52回児童青年精神医学会総会
  • Place of Presentation: あわぎんホール(徳島県) (シンポジウム)
• [Presentation] Relationship between the level of difficulty of task and hemodynamic change measured by NIRS (2011)
  • Author(s): S Sumitani, Y Uenishi, S Watanabe, Y Watanabe, M Akiyama, T Ohmori
  • Organizer: 10^<th> World Congress of Biological Psychiatry Prague Congress Centre
  • Place of Presentation: Czech Republic, Prague
• [Presentation] Relationship between he level of difficulty of task and hemodynamic change measured by NIRS (2011)
  • Author(s): S.Sumitani
  • Organizer: 10th World Conbress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 仮名と漢字における認知処理過程の差異－NIRSを用いた検討－
  • Author(s): 住谷さつき
  • Organizer: 第12回精神疾患と認知機能研究会
  • Place of Presentation: 海運クラブ（東京都）
• [Book] 子どもの心の処方箋ガイド (2014)
  • Author(s): 住谷さつき 分担
  • Total Pages: 370
  • Publisher: 中山書店
• [Book] 脳とこころのプライマリケア6 幻覚と妄想（堀口淳編集） (2011)
  • Author(s): 友竹正人，他
  • Publisher: シナジー