| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of the present study was to investigate the extended clinical course of dementia with Lewy bodies (DLB). First, sixteen patients had been prospectively followed for 2 years and their cognitive function was assessed by MMSE annually. It became apparent that cognitive function of the patients with DLB could be maintained at least for one year with medication, however, cognitive function declined after 2 years of the baseline assessment despite the continuation of medication. Second, we evaluated the impact of severity of dementia on expression of BPSD in patients with DLB and Alzheimer’s disease (AD). It became evident that the relationship of dementia stage with the expression of BPSD was different according to the type of dementia. BPSD and dementia stage were correlated in AD subjects, in whom psychiatric symptoms increase as the disease progresses, but not in DLB subjects. These findings provide the important information in the management of patients with DLB.
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