Longitudinal study of Dementia with Lewy bodies
| Project/Area Number |
23591717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Manabu 熊本大学, 生命科学研究部, 教授 (60284395)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | レビー小体型認知症 / 臨床経過 / 症候学 / 長期経過 / 臨床症候 / DLB / 国際情報交流 |
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| Outline of Final Research Achievements |
The aim of the present study was to investigate the extended clinical course of dementia with Lewy bodies (DLB). First, sixteen patients had been prospectively followed for 2 years and their cognitive function was assessed by MMSE annually. It became apparent that cognitive function of the patients with DLB could be maintained at least for one year with medication, however, cognitive function declined after 2 years of the baseline assessment despite the continuation of medication. Second, we evaluated the impact of severity of dementia on expression of BPSD in patients with DLB and Alzheimer’s disease (AD). It became evident that the relationship of dementia stage with the expression of BPSD was different according to the type of dementia. BPSD and dementia stage were correlated in AD subjects, in whom psychiatric symptoms increase as the disease progresses, but not in DLB subjects. These findings provide the important information in the management of patients with DLB.
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] Relationship between dementia severity and behavioral and psychological symptoms of dementia in dementia with Lewy bodies and Alzheimer’s disease patients.2015
Author(s)
Hashimoto M, Yatabe Y, Ishikawa T, Fukuhara R, Kaneda K, Honda K, Yuki S, Ogawa Y, Imamura T, Kazui H, Kamimura N, Shinagawa S, Mizukami K, Mori E, Ikeda M
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Journal Title
Dementia Geriatr Cogn Disord EXTRA
Volume: -
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Relationship between dementia severity and behavioural and psychological symptoms in early-onset Alzheimer's disease.2015
Author(s)
Tanaka H, Hashimoto M, Fukuhara R, Ishikawa T, Yatabe Y, Kaneda K, Yuuki S, Honda K, Matsuzaki S, Tsuyuguchi A, Hatada Y, Ikeda M.
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Journal Title
Psychogeriatrics
Volume: -
Issue: 4
Pages: 242-7
DOI
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Peer Reviewed / Open Access
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[Journal Article] The usefulness of monitoring sleep talking for the diagnosis of dementia with Lewy bodies.2013
Author(s)
Honda K, Hashimoto M, Yatabe Y, Kaneda K, Yuki S, Ogawa Y, Matsuzaki S, Tsuyuguchi A, Tanaka H, Kashiwagi H, Hasegawa N, Ishikawa T, IkedaM.
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Journal Title
Int Psychogeriatr.
Volume: 25(5)
Pages: 851-858
Related Report
Peer Reviewed
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[Journal Article] Prevalence and Topography of Small Hypointense Foci Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia.2013
Author(s)
Uetani H, Hirai T, Hashimoto M, Ikeda M, Kitajima M, Sakamoto F, Utsunomiya D, Oda S, Sugiyama S, Matsubara J, Yamashita Y
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Journal Title
Am J Neuroradiol.
Volume: 34(5)
Issue: 5
Pages: 984-989
DOI
Related Report
Peer Reviewed
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[Presentation] レビー小体型の薬物療法2014
Author(s)
橋本 衛
Organizer
第29回日本老年精神医学会総会
Place of Presentation
千代田区、日本教育会館
Year and Date
2014-06-12 – 2014-06-13
Related Report
Invited
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[Presentation] Relationship between dementia severity and behavioral and psychological symptoms of dementia in dementia with Lewy bodies and Alzheimer’s disease patients.2013
Author(s)
Hashimoto M, Ogawa Y, Yatabe Y, Yuki S, Imamura T, Kazui H, Fukuhara R, Kamimura N, Shinagawa S, Mizukami K, Mori E, Ikeda M
Organizer
16th International Congress of International psychogeriatrics association.
Place of Presentation
Seoul Korea
Related Report
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