Neural correlate of abnormal eating behavior in semantic dementia
| Project/Area Number |
23591718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kumamoto University |
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Principal Investigator |
IKEDA Manabu 熊本大学, 大学院生命科学研究部, 教授 (60284395)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Mamoru 熊本大学, 医学部附属病院, 講師 (20452881)
HIRAI Toshinori 熊本大学, 大学院生命科学研究部, 准教授 (40274724)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 老年精神医学 / 神経回路 / 認知症 / 前頭側頭型認知症 / 意味性認知症 / 食行動 / 過食 / 異食 / 嗜好 / 神経基盤 |
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| Research Abstract |
As is well known, patients with frontotemporal lobar degeneration (FTLD) show various abnormal eating behaviors. However there are few researches focused on eating behavior in semantic dementia (SD) that is a clinical subtype of FTLD. Subjects were 19 SD patients, in which assessment scale of eating behaviors and brain SPECT were undergone. The assessment scale consists of 5 domains: swallowing problem, appetite change, food preference, eating habits and other oral behaviors. Semi-quantitative methods were used to assess rCBF changes. Regional tracer uptake was measured in region of interest (ROI) over the bilateral superior and inferior frontal cortex, lateral and medial temporal cortex, thalamus and cerebellum, and calculated ROI ratios divided by ROI in cerebellum. Using partial correlation analysis adjusted by duration of illness showed significant correlations between right frontal cortex and increased appetite, and between bilateral temporal cortex and changes of food preference.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Multicenter population-based study on the prevalence of early onset dementia in Japan : Vascular dementia as its prominent cause2014
Author(s)
Ikejima C, Ikeda M, Hashimoto M, Ogawa Y, Tanimukai S, Kashibayashi T, Miyanaga K, Yonemura K, Kakuma T, Murotani K, Asada T
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 68
Pages: 216-224
Related Report
Peer Reviewed
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[Journal Article] Maluticenter population-based study on the prevalence of early onset dementia in Japan: Vascular dementia as its prominent cause2014
Author(s)
Ikejima C, Ikeda M, Hashimoto M, Ogawa Y, Tanimukai S, Kashibayashi T, Miyanaga K, Yonemura K, Kakuma T, Morotani K, Asada T
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 68
Pages: 216-241
Related Report
Peer Reviewed
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[Journal Article] The usefulness of monitoring sleep talking for the diagnosis of dementia with Lewy bodies2013
Author(s)
Honda K, Hashimoto M, Yatabe Y, Kaneda K, Yuki S, Ogawa Y, Matsuzaki S, Tsuyuguchi A, Tanaka H, Kashiwagi H, Hasegawa N, Ishikawa T, Ikeda M
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Journal Title
Int Psychogeriatrics
Volume: 25
Pages: 851-858
Related Report
Peer Reviewed
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[Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases2013
Author(s)
Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Yoko Shimomura a, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H
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Journal Title
Journal of the Neurological Sciences
Volume: 335
Pages: 89-95
Related Report
Peer Reviewed
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[Journal Article] Long-term safety and efficacy of Donepezil in patients with dementia with Lewy Bodies: Results from a 52-week, open-label, multicenter extension study2013
Author(s)
Ikeda M, Mori E, Kosaka K, Iseki E, Hashimoto M, Matsukawa N, Matsuo K, Nakagawa M, on behalf of the Donepezil-DLB Study Investigators
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Journal Title
Dement Geriatr Cogn Disord
Volume: 36
Pages: 229-241
Related Report
Peer Reviewed
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[Journal Article] Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia(2013発行予定)2013
Author(s)
Uetani H, Hirai T, Hashimoto M, Ikeda M, Kitajima M, Sakamoto F, Utsunomiya D, Oda S, Sugiyama S, Matsubara J, Yamashita
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Journal Title
Am J Neuroradiol
Volume: Epub ahead of print
Related Report
Peer Reviewed
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[Presentation] Depressive state in caregivers of patients with dementia2012
Author(s)
Hasegawa N, Koyama A, Hashimoto M, Ishikawa T, Yatabe Y, Kaneda K, Honda K, Yuuki S, Ogawa Y, Araki K, Ikeda M
Organizer
International Psychiatric Association International Meeting 2012
Place of Presentation
Kuala Lumpur,Malaysia
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