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Neural correlate of abnormal eating behavior in semantic dementia

Research Project

Project/Area Number 23591718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKumamoto University

Principal Investigator

IKEDA Manabu  熊本大学, 大学院生命科学研究部, 教授 (60284395)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Mamoru  熊本大学, 医学部附属病院, 講師 (20452881)
HIRAI Toshinori  熊本大学, 大学院生命科学研究部, 准教授 (40274724)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords老年精神医学 / 神経回路 / 認知症 / 前頭側頭型認知症 / 意味性認知症 / 食行動 / 過食 / 異食 / 嗜好 / 神経基盤
Research Abstract

As is well known, patients with frontotemporal lobar degeneration (FTLD) show various abnormal eating behaviors. However there are few researches focused on eating behavior in semantic dementia (SD) that is a clinical subtype of FTLD. Subjects were 19 SD patients, in which assessment scale of eating behaviors and brain SPECT were undergone. The assessment scale consists of 5 domains: swallowing problem, appetite change, food preference, eating habits and other oral behaviors. Semi-quantitative methods were used to assess rCBF changes. Regional tracer uptake was measured in region of interest (ROI) over the bilateral superior and inferior frontal cortex, lateral and medial temporal cortex, thalamus and cerebellum, and calculated ROI ratios divided by ROI in cerebellum. Using partial correlation analysis adjusted by duration of illness showed significant correlations between right frontal cortex and increased appetite, and between bilateral temporal cortex and changes of food preference.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (65 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 21 results) Presentation (22 results) (of which Invited: 2 results) Book (20 results)

  • [Journal Article] Multicenter population-based study on the prevalence of early onset dementia in Japan : Vascular dementia as its prominent cause2014

    • Author(s)
      Ikejima C, Ikeda M, Hashimoto M, Ogawa Y, Tanimukai S, Kashibayashi T, Miyanaga K, Yonemura K, Kakuma T, Murotani K, Asada T
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 68 Pages: 216-224

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maluticenter population-based study on the prevalence of early onset dementia in Japan: Vascular dementia as its prominent cause2014

    • Author(s)
      Ikejima C, Ikeda M, Hashimoto M, Ogawa Y, Tanimukai S, Kashibayashi T, Miyanaga K, Yonemura K, Kakuma T, Morotani K, Asada T
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 68 Pages: 216-241

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] on behalf of the Donepezil-DLB Study Investigators. Long-term safety and efficacy of Donepezil in patients with dementia with Lewy Bodies : Results from a 52-week, open-label, multicenter extension study2013

    • Author(s)
      Ikeda M, Mori E, Kosaka K, Iseki E, Hashimoto M, Matsukawa N, Matsuo K, Nakagawa M
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 36(3-4) Pages: 229-241

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of increasing donepezil in mild to moderate Alzheimer's disease patients who show a diminished response to 5 mg donepezil : a preliminary study2013

    • Author(s)
      Yatabe Y, Hashimoto M, Kaneda K, Honda K, Ogawa Y, Yuki S, Ikeda M
    • Journal Title

      Psychogeriatrics

      Volume: 13(2) Pages: 88-93

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of delirium among outpatients with dementia2013

    • Author(s)
      Hasegawa N, Hashimoto M, Yuki S, Honda K, Yatabe Y, Araki K, Ikeda M
    • Journal Title

      Int Psychogeriatr

      Volume: 25(11) Pages: 1877-1883

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between primary progressive aphasia and neurodegenerative dementia2013

    • Author(s)
      Ichimi N, Hashimoto M, Matsushita M, Yano H, Yatabe Y, Ikeda M
    • Journal Title

      East Asian Arch Psychiatry

      Volume: 23(3) Pages: 120-125

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the utility of everyday memory test and the Alzheimer's Disease Assessment Scale-Cognitive part for evaluation of mild cognitive impairment and very mild Alzheimer's disease2013

    • Author(s)
      Adachi H, Ikeda M, Komori K, Shinagawa S, Toyota Y, Kashibayashi T, Ishikawa T, Tachibana N
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 67(3) Pages: 148-153

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The usefulness of monitoring sleep talking for the diagnosis of dementia with Lewy bodies2013

    • Author(s)
      Honda K, Hashimoto M, Yatabe Y, Kaneda K, Yuki S, Ogawa Y, Matsuzaki S, Tsuyuguchi A, Tanaka H, Kashiwagi H, Hasegawa N, Ishikawa T, Ikeda M
    • Journal Title

      Int Psychogeriatrics

      Volume: 25 Pages: 851-858

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of the utility of the everyday memory test and Alzheimer’s Disease Assessment Scale-Cognition part (ADAS-Cog) for evaluation of mild cognitive impairment (MCI) and very mild Alzheimer’s disease2013

    • Author(s)
      Adachi H, Ikeda M, Komori K, Shinagawa S, Toyota Y, Kashibayashi T, Ishikawa T, Tachibana N
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 67 Pages: 148-153

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The relationship between primary progressive aphasia and neurodegenerative dementia2013

    • Author(s)
      Ichimi N, Hashimoto M, Matsushita M, Yano H, Yatabe Y, Ikeda M
    • Journal Title

      East Asian Archives of Psychiatry

      Volume: 23 Pages: 120-125

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of delirium among outpatients with dementia2013

    • Author(s)
      Hasegawa N, Hashimoto M, Yuuki S, Honda K, Yatabe Y, Araki K, Ikeda M
    • Journal Title

      International Psychogeriatrics

      Volume: 25 Pages: 1877-1883

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of increasing donepezil in mild to moderate Alzheimer’s disease patients who show a diminished response to 5 mg donepezil: a preliminary study2013

    • Author(s)
      Yatabe Y, Hashimoto M, Kaneda K, Honda K, Ogawa Y, Yuuki S, Ikeda M
    • Journal Title

      Psychogeriatrics

      Volume: 13 Pages: 88-93

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases2013

    • Author(s)
      Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Yoko Shimomura a, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 335 Pages: 89-95

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term safety and efficacy of Donepezil in patients with dementia with Lewy Bodies: Results from a 52-week, open-label, multicenter extension study2013

    • Author(s)
      Ikeda M, Mori E, Kosaka K, Iseki E, Hashimoto M, Matsukawa N, Matsuo K, Nakagawa M, on behalf of the Donepezil-DLB Study Investigators
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 36 Pages: 229-241

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia(2013発行予定)2013

    • Author(s)
      Uetani H, Hirai T, Hashimoto M, Ikeda M, Kitajima M, Sakamoto F, Utsunomiya D, Oda S, Sugiyama S, Matsubara J, Yamashita
    • Journal Title

      Am J Neuroradiol

      Volume: Epub ahead of print

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A comparison of family care infrastructure for demented elderly in inner cities and regional areas in Japan2012

    • Author(s)
      Shinagawa S, Yatabe Y, Hashimoto M, Nakayama K, Ikeda M
    • Journal Title

      Psychogeriatrics

      Volume: 12 Pages: 159-164

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Donepezil for demenia with Lewy bodies: a randomized, placebo-controlled trial.2012

    • Author(s)
      Mori Y, , Osaki Y.
    • Journal Title

      Ann Neurol

      Volume: 72 Issue: 1 Pages: 41-52

    • DOI

      10.1002/ana.23557

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gogi aphasia: The early description of semantic dementia in Japan2011

    • Author(s)
      Ikeda M, Kitamura I, Ichimi N, Hashimoto M, Lambon Ralph MA, Komori K
    • Journal Title

      Acta Neuropsychologica

      Volume: 9 Pages: 133-140

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 認知機能障害を伴う要介護高齢者の日常生活動作と行動・心理症状を測定する新評価票2011

    • Author(s)
      今井幸充,長田久雄,本間 昭,萱間真美,三上裕司,加藤伸司,木村隆次,石田光広,沖田裕子,遠藤英俊,池田 学,半田幸子
    • Journal Title

      日本老年精神医学雑誌

      Volume: 22 Pages: 1155-1165

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 前頭側頭葉変性症の臨床行動学 -抽象的態度の障害との関連 -2011

    • Author(s)
      橋本 衛,小川雄右,池田 学
    • Journal Title

      高次脳機能研究

      Volume: 31 Pages: 269-276

    • Related Report
      2011 Research-status Report
  • [Journal Article] 前頭側頭型認知症2011

    • Author(s)
      石川智久,池田 学
    • Journal Title

      総合臨牀

      Volume: 60 Pages: 1851-1858

    • Related Report
      2011 Research-status Report
  • [Journal Article] Patient-related factors associated with depressive state in caregivers of patients with dementia

    • Author(s)
      Hasegawa N, Hashimoto M, Koyama A, Ishikawa T, Yatabe Y, Honda K, Yuki S, Araki K, Ikeda M
    • Journal Title

      JAMDA

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is sense of coherence helpful in coping with caregiver burden for dementia?

    • Author(s)
      Matsushita M, Ishikawa T, Koyama A, Hasegawa N, Ichimi N, Yano H, Hashimoto M, Fujii N, Ikeda M
    • Journal Title

      Psychogeriatrics

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Keynote address : Overview on the diagnosis and management of frontotemporal lobar degeneration2014

    • Author(s)
      Ikeda M
    • Organizer
      9th Annual Meeting of Taiwanese Society of Geriatric Psychiatry
    • Place of Presentation
      Chung Shan Medical University, Taichung city, Taiwan
    • Year and Date
      2014-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ASAD Joint Symposium on Dementia : Frontotemporal Dementia in Asia2014

    • Author(s)
      Ikeda M
    • Organizer
      14th Asian & Oceanian Congress of Neurology
    • Place of Presentation
      The Venetian Macao, Macao, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Frontotemporal Dementia in Asia2014

    • Author(s)
      Ikeda M
    • Organizer
      14th Asian & Oceaninan Congress of Neurology, The Venetian Macao
    • Place of Presentation
      Macao, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] 若年性認知症を地域で支えるために2013

    • Author(s)
      池田学
    • Organizer
      第16回日本老年行動科学会
    • Place of Presentation
      愛媛県松山市 (基調講演)
    • Year and Date
      2013-08-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 褥瘡の危険因子を作らないための取り組み.(シンポジウム)「認知症の予防について」2013

    • Author(s)
      池田学
    • Organizer
      第15回日本褥瘡学会学術集会
    • Place of Presentation
      兵庫県神戸市 (発表19日)
    • Year and Date
      2013-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 認知症の病態と治療薬の動向(シンポジウム)「レビー小体型認知症と前頭側頭葉変性症の病態と治療」2013

    • Author(s)
      池田学
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      沖縄県宜野湾市
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Dementia care. Community outreach services for dementia : Basic requirements2013

    • Author(s)
      Ikeda M
    • Organizer
      7th Congress of Asian Society Against Dementia
    • Place of Presentation
      Cebu city, Philippines
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium : Frontotemporal lobar degeneration in Asia. FTLD in Asia–overview2013

    • Author(s)
      Ikeda M
    • Organizer
      International Psychiatric Association 16^<th> International Congress
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Frontotemporal lobar degeneration in Asia. FTLD in Asia - overview2013

    • Author(s)
      Ikeda M
    • Organizer
      International Psychiatric Association 16th International Congress
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dementia care. Community outreach services for dementia: Basic requirements2013

    • Author(s)
      Ikeda M
    • Organizer
      7th Congress of Asian Society Against Dementia
    • Place of Presentation
      Cebu city, Philippines
    • Related Report
      2013 Annual Research Report
  • [Presentation] レビー小体型認知症と前頭側頭葉変性症の病態と治療2013

    • Author(s)
      池田 学
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] The outreach intervention for early-onset dementia by multi-disciplinary staffs in Japan2012

    • Author(s)
      Ikeda M
    • Organizer
      Biennial meeting of World Federation of Neurology, Research Group of Aphasia & Cognitive Disorders
    • Place of Presentation
      Hyderabad,India
    • Related Report
      2012 Research-status Report
  • [Presentation] Therapeutic Strategies in Dementia with Lewy bodies2012

    • Author(s)
      Ikeda M
    • Organizer
      28th International Kumamoto Medical Bioscience Symposium
    • Place of Presentation
      熊本県医師会館
    • Related Report
      2012 Research-status Report
  • [Presentation] (Keynote Address)Older Adults and Mental Health in the Face of Natural Disasters-Tohoku Tsunami Disaster2012

    • Author(s)
      Ikeda M
    • Organizer
      International Psychiatric Association International Meeting 2012
    • Place of Presentation
      Cairns,Australia
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Depressive state in caregivers of patients with dementia2012

    • Author(s)
      Hasegawa N, Koyama A, Hashimoto M, Ishikawa T, Yatabe Y, Kaneda K, Honda K, Yuuki S, Ogawa Y, Araki K, Ikeda M
    • Organizer
      International Psychiatric Association International Meeting 2012
    • Place of Presentation
      Kuala Lumpur,Malaysia
    • Related Report
      2012 Research-status Report
  • [Presentation] Vascular lesions in neuro-degenerative dementia2012

    • Author(s)
      Ikeda M
    • Organizer
      6th Congress of Asian Society Against Dementia
    • Place of Presentation
      Kuala Lumpur,Malaysia
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Challenges in care management for early onset dementia2011

    • Author(s)
      Ikeda M, Komatsu Y, Maruyama T, Hasegawa N, Matsushita M, Yatabe Y, Hashimoto M
    • Organizer
      5th Congress of Asian Society Against Dementia
    • Place of Presentation
      Hong Kong
    • Related Report
      2011 Research-status Report
  • [Presentation] Eating behavior in dementia2011

    • Author(s)
      Ikeda M
    • Organizer
      Taiwan Dementia Society 2011(招待講演)
    • Place of Presentation
      Taipei
    • Related Report
      2011 Research-status Report
  • [Presentation] Pharmacotherapy for BPSD in fronto-temporal dementia in Japan2011

    • Author(s)
      Ikeda M
    • Organizer
      15th International Psychiatric Association
    • Place of Presentation
      Hague
    • Related Report
      2011 Research-status Report
  • [Presentation] 基調講演「認知症医療 -診断から生活支援まで-」2011

    • Author(s)
      池田 学
    • Organizer
      文部科学省学術フロンティア推進事業「認知症のトータルケアに関する学際的研究」公開シンポジウム(招待講演)
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 若年性認知症を地域で支えるために

    • Author(s)
      池田 学
    • Organizer
      第16回日本老年行動学会
    • Place of Presentation
      愛媛大学城北キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Overview on the diagnosis and management of frontotemporal lobar degeneration

    • Author(s)
      Ikeda M
    • Organizer
      9th Annual Meeting of Taiwanese Society of Geriatric Psychiatry
    • Place of Presentation
      Chung Shan Medical University, Taichung city, Taiwan
    • Related Report
      2013 Annual Research Report
  • [Book] 前頭側頭葉変性症(含:進行性失語症).第4版わかりやすい内科学2014

    • Author(s)
      池田学 (井村裕夫編)
    • Publisher
      文光堂,東京
    • Related Report
      2013 Final Research Report
  • [Book] 第4版わかりやすい内科学2014

    • Author(s)
      池田 学
    • Total Pages
      992
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] 脳の理解.認知症予防専門士テキストブック2013

    • Author(s)
      池田学 (浦上克哉,川瀬康裕,児玉直樹編)
    • Publisher
      徳間書店,東京
    • Related Report
      2013 Final Research Report
  • [Book] 前頭側頭型認知症.神経・精神疾患診療マニュアル2013

    • Author(s)
      池田学 (北川泰久,寺本明,三村將編)
    • Publisher
      日本医師会,東京
    • Related Report
      2013 Final Research Report
  • [Book] 認知症.脳血管障害と神経心理学第2版2013

    • Author(s)
      池田学 (平山恵造,田川皓一編)
    • Publisher
      医学書院,東京
    • Related Report
      2013 Final Research Report
  • [Book] 認知症とケア.脳とこころのプライマリケア2知能の衰え2013

    • Author(s)
      池田学,小松優子 (池田学編集)
    • Publisher
      シナジー,東京
    • Related Report
      2013 Final Research Report
  • [Book] 改訂阪老年病・認知症〜長寿の秘訣〜2013

    • Author(s)
      池田学 (荻原俊男監修)
    • Publisher
      メディカルレビュー社,東京
    • Related Report
      2013 Final Research Report
  • [Book] 梅毒.誤診症例から学ぶ認知症とその他の疾患の鑑別2013

    • Author(s)
      松崎志保,橋本衛,池田学
    • Publisher
      医学書院,東京
    • Related Report
      2013 Final Research Report
  • [Book] 認知症予防専門士テキストブック2013

    • Author(s)
      池田 学
    • Total Pages
      305
    • Publisher
      徳間書店
    • Related Report
      2013 Annual Research Report
  • [Book] 神経・精神疾患診療マニュアル2013

    • Author(s)
      池田 学
    • Total Pages
      362
    • Publisher
      日本医師会
    • Related Report
      2013 Annual Research Report
  • [Book] 脳血管障害と神経心理学 第2版2013

    • Author(s)
      池田 学
    • Total Pages
      550
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 脳とこころのプライマリケア2 知能の衰え2013

    • Author(s)
      池田 学,小松優子
    • Total Pages
      535
    • Publisher
      シナジー
    • Related Report
      2013 Annual Research Report
  • [Book] 今日の神経疾患治療指針2013

    • Author(s)
      池田 学,橋本 衛
    • Total Pages
      1100
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 今日の治療指針2013年版ー私はこう治療している2013

    • Author(s)
      池田 学
    • Total Pages
      1955
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] Principles of Deglutition: A Multidisciplinary Text for Swallowing and its Disorders2012

    • Author(s)
      Manabu Ikeda, John Hodges
    • Total Pages
      1017
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report
  • [Book] 認知症 臨床の最前線2012

    • Author(s)
      池田 学編
    • Total Pages
      232
    • Publisher
      医歯薬出版
    • Related Report
      2012 Research-status Report
  • [Book] BPSDの初期対応ガイドライン2012

    • Author(s)
      池田 学
    • Total Pages
      171
    • Publisher
      ライフ・サイエンス
    • Related Report
      2012 Research-status Report
  • [Book] 認知症 臨床の最前線2012

    • Author(s)
      池田 学(編著)
    • Total Pages
      232
    • Publisher
      医歯薬出版
    • Related Report
      2011 Research-status Report
  • [Book] 今日の精神疾患治療指針2012

    • Author(s)
      橋本 衛,池田 学(分担執筆)
    • Total Pages
      985
    • Publisher
      医学書院
    • Related Report
      2011 Research-status Report
  • [Book] 神経疾患最新の治療2012-20142012

    • Author(s)
      遊亀誠二,池田 学(分担執筆)
    • Total Pages
      436
    • Publisher
      南江堂
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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