Study for FKBP5 and CRHR1 in depression and panic disorder

• Project/Area Number: 23591719
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Oita University
• Principal Investigator: AKIYOSHI Jotaro 大分大学, 医学部, 准教授 (00159344)
• Co-Investigator(Kenkyū-buntansha): TANAKA Yoshihiro 大分大学, 医学部, 助教 (60516102) ; ISHITOBI Yoshinobu 大分大学, 医学部, 助教 (40516118) ; KOHNO Kentaro 大分大学, 医学部, 医員 (30555181) ; IMANAGA Junko 大分大学, 医学部, 医員 (30583504) ; INOUE Ayako 大分大学, 医学部, 医員 (10630949) ; ANDO Tomoko 大分大学, 医学部, 臨床心理士 (80516120) ; KAWANO Aimi 大分大学, 医学部, 臨床心理士 (80583492) ; 花田 浩昭 大分大学, 医学部, 助教 (80444884) ; 兼久 雅之 大分大学, 医学部, その他 (40555190) ; 丸山 義博 大分大学, 医学部, その他 (80555186)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: FKBP5 / CRHR1 / ストレス / 唾液アミラーゼ / 唾液コルチゾール / 遺伝子 / PCR / うつ病 / パニック障害 / 大うつ病性障害

Research Abstract

CRHR1 and FKBP5 gene were also found an association with depression and panic disorder. These genetic polymorphisms were found to be associated with anxiety. The context of FKBP5 gene polymorphism was significantly related to the VBM of frontal lobe and amygdala. CRHR1 genes and FKBP5 related to the stress were associated with depression and panic disorder. Our results showed that a significant interaction exists between FKBP5 SNPs, salivary cortisol and salivary amylase responses at three levels of regulation. Salivary cortisol and amylase responses were significantly associated with FKBP5. The brain volume could be also affected by these genes.

Research Products

• [Journal Article] Ishitobi Y, Nakayama S, Kanehisa M, Higuma H, Maruyama Y, Okamoto S, Inoue A, Imanaga J, Tanaka Y, Tsuru J, Hanada H, Akiyoshi J. (2013)
  • Author(s): Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.
  • Journal Title: Psychiatr Genet. Volume: 23 Issue: 6 Pages: 255-257
  • DOI: 10.1097/ypg.0000000000000002
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in patients with the generalized type of social anxiety disorder. (2013)
  • Author(s): Tamura A, Maruyama Y, Ishitobi Y, Kawano A, Ando T, Ikeda R, Inoue A, Imanaga J, Okamoto S, Kanehisa M, Ninomiya T, Tanaka Y, Tsuru J, Akiyoshi J.
  • Journal Title: Pharmacopsychiatry. Volume: 46 Issue: 07 Pages: 225-260
  • DOI: 10.1055/s-0033-1353157
  • Peer Reviewed
• [Journal Article] The thyrotropin-releasing hormone test may predict recurrence of clinical depression within ten years after discharge (2013)
  • Author(s): Tsuru J, Ishitobi Y, Ninomiya T, Kanehisa M, Imanaga J, Inoue A, Okamoto S, Maruyama Y, Higuma H, Tanaka Y, Hanada H, Isogawa K, Akiyoshi J
  • Journal Title: Neuro Endocrinol Lett Volume: 34(5) Pages: 409-17
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in obsessive-compulsive disorder patients (2013)
  • Author(s): Kawano A, Tanaka Y, Ishitobi Y, Maruyama Y, Ando T, Inoue A, Okamoto S, Imanaga J, Kanehisa M, Higuma H, Ninomiya T, Tsuru J, Akiyoshi J
  • Journal Title: Psychiatry Res Volume: 209(1) Pages: 85-90
  • Peer Reviewed
• [Journal Article] The value of ethyl cysteinate dimer single photon emission computed tomography in predicting antidepressant treatment response in patients with major depression. (2013)
  • Author(s): Hanada H, Imanaga J, Yoshiiwa A, Yoshikawa T, Tanaka Y, Tsuru J, Inoue A, Ishitobi Y, Okamoto S, Kanehisa M, Maruyama Y, Ninomiya T, Higuma H, Isogawa K, Kawasaki T, Fujioka T, Akiyoshi J.
  • Journal Title: Int J Geriatr Psychiatry. Volume: 28 Issue: 7 Pages: 756-765
  • DOI: 10.1002/gps.3887
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in obsessive-compulsive disorder patients. (2013)
  • Author(s): Kawano A, Tanaka Y, Ishitobi Y, Maruyama Y, Ando T, Inoue A, Okamoto S, Imanaga J, Kanehisa M, Higuma H, Ninomiya T, Tsuru J, Akiyoshi J.
  • Journal Title: Psychiatry Res. Volume: 209 Pages: 85-90
  • Peer Reviewed
• [Journal Article] The thyrotropin-releasing hormone test may predict recurrence of clinical depression within ten years after discharge. (2013)
  • Author(s): Tsuru J, Ishitobi Y, Ninomiya T, Kanehisa M, Imanaga J, Inoue A, Okamoto S, Maruyama Y, Higuma H, Tanaka Y, Hanada H, Isogawa K, Akiyoshi J.
  • Journal Title: Neuro Endocrinol Lett. Volume: 34 Pages: 409-417
  • Peer Reviewed
• [Journal Article] Hippocampal agenesis in an individual who engaged in violent criminal behaviors after discontinuing carbamazepine and paroxetine treatment. (2013)
  • Author(s): Hiroaki Hanada, Jotaro Akiyoshi, Masayuki Kanehisa, Yoshinobu Ishitobi, Jusen Tsuru, Yoshihiro Tanaka, Tsuyoshi Shimomura, Yoshihisa Kawano.
  • Journal Title: Journal of forensic sciences Volume: 58(1) Issue: 1 Pages: 255-258
  • DOI: 10.1111/j.1556-4029.2012.02248.x
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in panic disorder patients. (2012)
  • Author(s): Yoshihiro Tanaka, Yoshinobu Ishitobi, Jotaro Akiyoshi. et al
  • Journal Title: Neuroscience Research Volume: 73(1) Issue: 1 Pages: 80-84
  • DOI: 10.1016/j.neures.2012.01.006
  • Peer Reviewed
• [Journal Article] Serum ghrelin levels and the effects of antidepressants in major depressive disorder and panic disorder. (2012)
  • Author(s): Yoshinobu Ishitobi, Kentaro Kohno,Jotaro Akiyoshi. et al
  • Journal Title: Neuropsychobiology Volume: 66(3) Issue: 3 Pages: 185-192
  • DOI: 10.1159/000339948
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in obsessive-compulsive disorder patients. (2012)
  • Author(s): Aimi Kawano, Yoshihiro Tanaka,Jotaro Akiyoshi. et al
  • Journal Title: Psychiatry Research Volume: article in press Issue: 1 Pages: 85-90
  • DOI: 10.1016/j.psychres.2012.11.010
  • Peer Reviewed
• [Journal Article] An uncommon case of random fire-setting behavior associated with Todd paralysis: a case report. (2012)
  • Author(s): Masayuki Kanehisa, Katsuhiko Morinaga, Hisae Kohno, Yoshihiro Maruyama, Taiga Ninomiya, Yoshinobu Ishitobi, Yoshihiro Tanaka, Jusen Tsuru, Hiroaki Hanada, Tomoya Yoshikawa, Jotaro Akiyoshi.
  • Journal Title: BMC Psychiatry Volume: 12 Issue: 1 Pages: 132-132
  • DOI: 10.1186/1471-244x-12-132
  • Peer Reviewed
• [Journal Article] Differences in salivary alpha-amylase and cortisol responsiveness following exposure to electrical stimulation versus the Trier Social Stress Tests. (2012)
  • Author(s): Yoshihiro Maruyama, Aimi Kawano,Jotaro Akiyoshi. et al
  • Journal Title: PLoS One Volume: 7(7) Issue: 7 Pages: e39375-e39375
  • DOI: 10.1371/journal.pone.0039375
  • Peer Reviewed
• [Journal Article] パニック障害(特集:メンタル医療の最新動向) (2012)
  • Author(s): 五十川浩一, 穐吉條太郎
  • Journal Title: ファインケミカル Volume: 41(7) Pages: 44-45
• [Journal Article] 多職種チームでの臨床心理士の役割 大分大学医学部附属病院救命救急センターにおける自殺未遂者ケア(特集:自殺対策 多職種でかかわる自殺未遂者ケア:ポイントと課題) (2012)
  • Author(s): 安東友子, 塩月一平, 穐吉條太郎, 寺尾 岳
  • Journal Title: 救急医学 Volume: 36(7) Pages: 829-832
  • NAID: 40019385400
• [Journal Article] 不安障害の病態と診断(特集:不安障害の病態・診断・治療の最前線) (2012)
  • Author(s): 穐吉條太郎
  • Journal Title: 精神神経学雑誌 Volume: 114(9) Pages: 1063-1069
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in panic disorder patients. (2012)
  • Author(s): Tanaka Y, Ishitobi Y, Akiyoshi J et al.
  • Journal Title: Neurosci Res Volume: 73(1) Pages: 80-84
  • Peer Reviewed
• [Journal Article] Administration of antisense DNA for GPR39-1b causes anxiolytic-like responses and appetite loss in rats. (2012)
  • Author(s): Ishitobi Y, Akiyoshi J, et al.
  • Journal Title: Neurosci Res Volume: 72(3) Pages: 257-262
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in major depressive disorder patients. (2012)
  • Author(s): Tanaka Y, Ishitobi Y, Akiyoshi J et al.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. Volume: 36(2) Pages: 220-224
  • Peer Reviewed
• [Journal Article] Aripprazole augmentation in 13 patients with refractory obsessive compulsive disorder a case series. (2012)
  • Author(s): Higuma H, Kanehisa M, Akiyoshi J et al.
  • Journal Title: World J Biol Psychiatry Volume: 13(1) Pages: 14-21
  • Peer Reviewed
• [Journal Article] Infrared radiation has potential antidepressant and anxiplytic effects in animal model of depression and anxiety. (2011)
  • Author(s): Yoshihiro Tanaka, Jotaro Akiyoshi et al.
  • Journal Title: Brain Stimil. Volume: 4 Pages: 71-76
  • Peer Reviewed
• [Journal Article] がん告知後に発症したうつ病の1例（in Japanese) (2011)
  • Author(s): 森永克彦、引地孝俊、兼久雅之、日隈晴香、穐吉條太郎
  • Journal Title: 精神科 Volume: 19（1） Pages: 66-69
• [Journal Article] 不安障害治療の現在・過去・未来（in Japanese） (2011)
  • Author(s): Ishogawa K, Tanaka Y, Akiyoshi J
  • Journal Title: ファルマシア Volume: 47(9) Pages: 833-838
• [Presentation] 機能画像法によるヒト脳注意関連神経回路と遺伝多形 (2014)
  • Author(s): 山田和寛, 藤井康右, 黒木千尋, 穐吉條太郎, 河野義久
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス(鹿児島)
• [Presentation] 機能画像法によるヒト脳注意関連神経回路と遺伝多形 (2014)
  • Author(s): 山田和寛, 藤井康右, 黒木千尋, 穐吉條太郎, 河野義久.
  • Organizer: 第91回日本生理学会大会.
  • Place of Presentation: 鹿児島大学 郡元キャンパス(鹿児島)
• [Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction (2013)
  • Author(s): Akiyoshi J, Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Inoue A, Kawano A, Ando T, Imanaga J, Okamoto S, Kanehisa M
  • Organizer: 21st World Congress of Psychiatric Genetics
  • Place of Presentation: Seaport Hotel & World Trade Center(アメリカ、ボストン)
• [Presentation] Association between transcription of neuroplasticity-related genes and variation in stress coping-style (2013)
  • Author(s): Aizawa S, Ishitobi Y, Ando T, Kawano A, Ikeda R, Inoue A, Kanehisa M, Higuma H, Ninomiya T, Maruyama Y, Okamoto S, Imanaga J, Tsuru J, Tanaka Y, Akiyoshi J
  • Organizer: 21st World Congress of Psychiatric Genetics
  • Place of Presentation: Seaport Hotel & World Trade Center(アメリカ、ボストン)
• [Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction (2013)
  • Author(s): Akiyoshi J, Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Kawano A, Ando T, Inoue A, Imanaga J, Okamoto S, Kanehisa M
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] The catechol-O-methultransferase gene (COMT), other gene polymorphism and congnitive function (2013)
  • Author(s): Ishitobi Y, Tanaka Y, Maruyama Y, Kawano A, Ando T, Inoue A, Okamoto S, Imanaga J, Kanehisa M, Higuma H, Ninomiya T, Tsuru J, Akiyoshi J
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction. (2013)
  • Author(s): Jotaro A, Jusen T, Yoshihiro T, Yoshinobu I, Yoshihiro M, Aimi K, Tomoko A, Ayako I, Junko I, Shizuko O, Masayuki K.
  • Organizer: 11th World Congress of Biological Psychiatry.
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] The catechol-O-methultransferase gene (COMT), other gene polymorphism and congnitive function. 11th World Congress of Biological Psychiatry. (2013)
  • Author(s): Yoshinobu I, Yoshihiro T, Yoshihiro M, Aimi K, Tomoko A, Ayako I, Shizuko O, Junko I, Masayuki K, Haruka H, Taiga N, Jusen T, Jotaro A.
  • Organizer: 11th World Congress of Biological Psychiatry.
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction. (2013)
  • Author(s): Jotaro A, Jusen T, Yoshihiro T, Yoshinobu I, Yoshihiro M, Ayako I, Aimi K, Tomoko A, Junko I, Shizuko O, Masayuki K
  • Organizer: 21st World Congress of Psychiatric Genetics.
  • Place of Presentation: Seaport Hotel&World Trade Center(アメリカ、ボストン)
• [Presentation] Association between transcription of neuroplasticity-related genes and variation in stress coping-style. (2013)
  • Author(s): Saeko A, Yoshinobu I, Tomoko A, Aimi K, Rie I, Ayako I, Masayuki K, Haruka H, Taiga N, Yoshihiro M, Shizuko O, Junko I, Jusen T, Yoshihiro T, Jotaro A.
  • Organizer: 21st World Congress of Psychiatric Genetics.
  • Place of Presentation: Seaport Hotel&World Trade Center(アメリカ、ボストン)
• [Presentation] 認知行動療法の科学的根拠について (2013)
  • Author(s): 穐吉條太郎
  • Organizer: 第5回日本不安障害学会学術大会
  • Place of Presentation: 札幌
• [Presentation] 不安障害の病態と診断 (2012)
  • Author(s): 穐吉條太郎
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 双極性障害における物理的ストレスによる唾液アミラーゼ反応 (2012)
  • Author(s): 田中悦弘、石飛佳宣、安東友子、河野愛生、丸山義博、岡本静子、兼久雅之、二宮大雅、津留壽船、花田浩昭、児玉健介、穐吉條太郎
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 双極性障害における感覚運動統合の機能不全とストレスの関連研究 (2012)
  • Author(s): 今永淳子、井上綾子、上田萌江、石飛佳宣、田中悦弘、河野愛生、安東友子、兼久雅之、日隈晴香、丸山義博、二宮大雅、岡本静子、津留壽船、穐吉條太郎
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 回避性パーソナリティ障害における電気刺激ストレスによる唾液アミラーゼ・コルチゾール反応 (2012)
  • Author(s): 丸山義博、石飛佳宣、田中悦弘、河野愛生、安東友子、岡本静子、井上綾子、今永淳子、兼久雅之、日隈晴香、二宮大雅、津留壽船、花田浩昭、穐吉條太郎
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 社交不安障害患者における唾液アミラーゼ・コルチゾールの反応 (2012)
  • Author(s): 田村亜佑美、石飛佳宣、田中悦弘、河野愛生、安東友子、井上綾子、今永淳子、兼久雅之、日隈晴香、丸山義博、二宮大雅、岡本静子、津留壽船、穐吉條太郎
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 機能的MRIにおける恐怖表情認識とCRH遺伝子の関連研究 (2012)
  • Author(s): 藤内美里、石飛佳宣、井上綾子、兼久雅之、日隈晴香、丸山義博、二宮大雅、岡本静子、田中悦弘、津留壽船、花田浩昭、児玉健介、穐吉條太郎
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] うつ病およびパニック障害におけるTMEM132D遺伝子・COMT遺伝子・GABRA6遺伝子とfMRIの関連研究 (2012)
  • Author(s): 井上綾子、上田萌江、石飛佳宣、田中悦弘、兼久雅之、日隈晴香、丸山義博、二宮大雅、岡本静子、津留壽船、花田浩昭、児玉健介、穐吉條太郎
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Salivary α-amylase and cortisol responsiveness following electrical physical stress in bipolar disorder patients (2012)
  • Author(s): Jotaro Akiyoshi, Yoshihiro Tanaka, Yoshinobu Ishitobi. et al
  • Organizer: 42nd International Society of Psychoneuroendocrinology Conference
  • Place of Presentation: アメリカ・ニューヨーク
• [Presentation] Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population (2012)
  • Author(s): Yoshinobu Ishitobi, Shinya Nakayama, Jotaro Akisyohi. et al
  • Organizer: 42nd International Society of Psychoneuroendocrinology Conference
  • Place of Presentation: アメリカ・ニューヨーク
• [Presentation] Ultrasound induced administration of DNA for hepatocyte growth factor causes an antidepressive and anxiolytic response in rats (2012)
  • Author(s): Masayuki Kanehisa, Yu Hashimoto, Jotaro Akiyoshi. et al
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] 電気刺激ストレスにおける唾液アミラーゼ、コルチゾールとBDNF遺伝子多型との関連研究 (2012)
  • Author(s): 津留壽船、石飛佳宣、丸山義博、田中悦弘、河野愛生、安東友子、岡本静子、今永淳子、井上綾子、兼久雅之、日隈晴香、二宮大雅、花田浩昭、穐吉條太郎
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] うつ病・不安モデルにおける新しい近赤外線照射による抗うつ・抗不安効果 (2012)
  • Author(s): 岸田康雅、石飛佳宣、田中悦弘、津留壽船、兼久雅之、井上綾子、今永淳子、日隈晴香、丸山義博、二宮大雅、岡本静子、花田浩昭、 五十川浩一、穐吉條太郎
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] パニック障害における感覚運動統合の機能不全とストレスの関連研究 (2012)
  • Author(s): 藍澤早恵子、今永淳子、井上綾子、石飛佳宣、田中悦弘、河野愛生、安東友子、兼久雅之、日隈晴香、丸山義博、二宮大雅、岡本静子、津留壽船、穐吉條太郎
  • Organizer: 第65回九州精神神経学会
  • Place of Presentation: 大分
• [Presentation] Ultrasound induced administration of DNA for hepatocyte growth factor causes an antidepressive and anxiolytic responcce in rats. (2011)
  • Author(s): M. Kanehisa, T. Ninomiya, J Akiyoshi et al.
  • Organizer: Society for Neuroscience2011.
  • Place of Presentation: ワシントン
• [Presentation] Aripiprazole augmentation in 13 patients with refractory obsessive-compulsive disorder: A case series. (2011)
  • Author(s): H. Higuma, M. Kanehisa, J Akiyoshi et al.
  • Organizer: Society for Neuroscience2011.
  • Place of Presentation: ワシントン
• [Presentation] Difference of salivary alpha-amylase and cortisol response following electrical stimulation stress in Obsessive Compulsive Disorder. (2011)
  • Author(s): A. Kawano, J. Akiyoshi et al.
  • Organizer: Society for Neuroscience2011.
  • Place of Presentation: ワシントン
• [Presentation] Difference of salivary alpha-amylase and cortisol response following electric stimulation stress and Trier Social Stress Tests in healthy volunteers. (2011)
  • Author(s): Y. Maruyama, A. Kawano, J Akiyoshi et al.
  • Organizer: Society for Neuroscience2011.
  • Place of Presentation: ワシントン
• [Presentation] Association between corticotrophin-releasing hormone receptor 1&2(CRHR1&2) gene polymorphism and personality traits. (2011)
  • Author(s): Y. Ishitobi, M. Kanehisa, J Akiyoshi et al.
  • Organizer: Society for Neuroscience2011.
  • Place of Presentation: ワシントン
• [Presentation] Changes in dorsolateral prefrontal cerebral cortex perfusion after antidepressant treatment for geriatric depression: A 99mTc-ECS SPECT study. Anxiety and Depression (2011)
  • Author(s): J. Akiyoshi, H. Hanada et al.
  • Organizer: 21st Neuropharmacology Conference.
  • Place of Presentation: アメリカ
• [Presentation] 老年期うつ病における抗うつ薬投与後の寛解・非寛解におけるSPECT変化. (2011)
  • Author(s): 今永淳子, 吉岩あおい, 穐吉條太郎 他13名
  • Organizer: 第107回日本精神神経学会学術総会.
  • Place of Presentation: 東京
• [Presentation] 肝細胞成長因子(HGF)遺伝子脳内強制発現による不安・抑うつ行動解析. (2011)
  • Author(s): 兼久雅之, 橋本侑, 穐吉條太郎 他9名
  • Organizer: 第107回日本精神神経学会学術総会.
  • Place of Presentation: 東京
• [Presentation] 大うつ病性障害およびパニック障害とFKBP5遺伝子の関連研究. (2011)
  • Author(s): 畠中健吾, 兼久雅之,穐吉條太郎 他9名
  • Organizer: 第107回日本精神神経学会学術総会.
  • Place of Presentation: 東京
• [Book] ストレスの基本理解と抗ストレス食品の開発(横越英彦 監修) (2011)
  • Author(s): 穐吉條太郎.
  • Publisher: シーエムシー出版.
• [Book] 不安障害の臨床 (2011)
  • Author(s): 穐吉條太郎、五十川浩一、河野伸子
  • Total Pages: 99
  • Publisher: 新興医学出版社
• [Book] Different views of anxiety disorders(Edit by Salih Selek) (2011)
  • Author(s): Jotaro Akiyoshi, Yoshihiro Tanaka et al.
  • Publisher: INTECH.