An investigation of neural substrates for decision-making disorder in OCD using fMRI with neurocomputational model

• Project/Area Number: 23591724
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: NARUMOTO Jin 京都府立医科大学, 医学(系)研究科(研究院), 講師 (30347463)
• Co-Investigator(Kenkyū-buntansha): KAWAWAKI Saori 株式会社国際電気通信基礎技術研究所, 脳情報通信総合研究所, 研究員 (00505985) ; YAMADA Kei 京都府立医科大学, 医学研究科, 教授 (80315960)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 強迫性障害 / 機能的MRI / 計算論 / 脳・神経 / MRI / 意思決定

Research Abstract

Patients with obsessive-compulsive disorder (OCD) impulsively act on compulsive behaviors to reduce obsession-related anxiety despite profound disadvantages to their life. Cumulative evidence has suggested dysfunctions of the ventral striatum and serotonergic function. We measured neural activity while subjects performed reward task by using fMRI. Activities in the ventral striatum of patients with OCD had a greater correlation with short-term reward prediction (steeper discounting) while activities in the dorsal striatum had less correlation with long-term reward prediction (slower discounting) compared with healthy controls. The result supports our hypothesis that expanded specialization for short-term reward prediction in the striatum underlies the neural substrates of OCD patients. These results suggest that abnormal activity of ventral striatum underlies pathophysiology of OCD.

Research Products

• [Journal Article] Voxel-based Morphometry Multi-center Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. (2014)
  • Author(s): de Wit SJ, Narumoto J, et al.
  • Journal Title: Am J Psychiatry Volume: 171 Issue: 3 Pages: 340-349
  • DOI: 10.1176/appi.ajp.2013.13040574
  • Peer Reviewed
• [Journal Article] 強迫性障害における認知機能障害 (2013)
  • Author(s): 中前貴,成本迅
  • Journal Title: 臨床精神医学 Volume: 42(12) Pages: 1513-1520
  • URL: http://mol.medicalonline.jp/library/journal/abstract?GoodsID=ao1clphd/2013/004212/009&name=1513-1520j&UserID=114.179.109.10
• [Journal Article] 精神科領域における最近のMRIの進歩安静時fMRI―精神科臨床研究への応用― (2013)
  • Author(s): 酒井雄希, 成本迅, 中前貴, 福居顯二
  • Journal Title: 月刊精神科 Volume: 22(4) Pages: 370-374
  • URL: http://jglobal.jst.go.jp/public/20090422/201302221628971634
• [Journal Article] Reduced Dorsolateral Prefrontal Cortex Hemodynamic Response in Adult Obsessive-Compulsive Disorder as Measured by Near-Infrared Spectroscopy during the verbal fluency task. (2013)
  • Author(s): Hirosawa R, Narumoto J, Sakai Y, Nishida S, Ishida T, Nakamae T, Takei Y, Fukui K.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: 9 Pages: 955-962
  • DOI: 10.2147/ndt.s45402
  • Peer Reviewed
• [Journal Article] 臨床医学研究を遂行するコツ 臨床研究で画像を取り扱うコツ． (2012)
  • Author(s): 成本 迅
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 32 Pages: 143-148
• [Journal Article] Relationship between severity of obsessive-compulsive symptoms and schizotypy in obsessive-compulsive disorder. (2012)
  • Author(s): Yamamoto H, Tsuchida H, Nakamae T, Nishida S, Sakai Y, Fujimori A, Narumoto J, Wada Y, Yoshida T, Taga C, Fukui K.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 8 Pages: 579-583
  • DOI: 10.2147/ndt.s38450
  • Peer Reviewed
• [Journal Article] 衝動的選択に関するセロトニンの計算論とイメージング (2011)
  • Author(s): 田中沙織,酒井雄希,成本迅,銅谷賢治
  • Journal Title: 臨床精神医学 Volume: 40 Pages: 479-489
  • URL: http://mol.medicalonline.jp/library/journal/download?GoodsID=ao1clphd/2011/004004/008&name=0479-0489j&UserID=114.179.109.10
• [Journal Article] Corticostriatal Functional Connectivity in Non-medicated Patients with Obsessive-Compulsive Disorder (2011)
  • Author(s): Sakai Y, Narumoto J, Nishida S, Nakamae T, Yamada K, Nishimura T, Fukui K
  • Journal Title: Eur Psychiatry Volume: 26 Issue: 7 Pages: 463-469
  • DOI: 10.1016/j.eurpsy.2010.09.005
  • Peer Reviewed
• [Journal Article] Anterior insular volume is larger in patients with obsessive-compulsive disorder (2011)
  • Author(s): Nishida S, Narumoto J, Sakai Y, Matsuoka T, Nakamae T, Yamada K, Nishimura T, Fukui K
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35(4) Issue: 4 Pages: 997-1001
  • DOI: 10.1016/j.pnpbp.2011.01.022
  • Peer Reviewed
• [Journal Article] Diffusion Tensor Imaging and Tract-Based Spatial Statistics in Obsessive-Compulsive Disorder (2011)
  • Author(s): Nakamae T, Narumoto J, Sakai Y, Nishida S, Yamada K, Nishimura T, Fukui K
  • Journal Title: J Psychiatr Res Volume: 45(5) Issue: 5 Pages: 687-90
  • DOI: 10.1016/j.jpsychires.2010.09.016
  • Peer Reviewed
• [Presentation] 強迫性障害の症状次元と関連する神経基盤について―脳血流SPECTを用いた検討― (2012)
  • Author(s): 伊藤惇,成本迅,酒井雄希,西田誠司,中前貴,奥山智緒,山田惠,福居顯二
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-29
• [Presentation] 無投薬強迫性障害患者における皮質厚と皮質表面積の検討 (2012)
  • Author(s): 中前貴,成本迅,西田誠司,酒井雄希,山田惠,久保田学,宮田淳,福居顯二
  • Organizer: 第4回日本不安障害学会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-04
• [Presentation] 無投薬強迫性障害患者における皮質厚と皮質表面積の検討． (2012)
  • Author(s): 中前 貴，成本 迅，西田誠司，酒井雄希，山田 惠，久保田学，宮田 淳，福居顯二．
  • Organizer: 第4回日本不安障害学会
  • Place of Presentation: 早稲田大学国際会議場（東京都）
• [Presentation] 安静時fMRIを用いた無投薬強迫性障害患者における線条体‐視床機能結合の変化 (2011)
  • Author(s): 酒井雄希,成本迅,西田誠司,中前貴,山田惠,西村恒彦,福居顯二
  • Organizer: 第107回日本精神神経学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-27
• [Presentation] Altered functional connectivity between the bilateral prefrontal cortex in obsessive-compulsive disorder (2011)
  • Author(s): Nakamae T, Narumoto J, Sakai Y, Nishida S, Yamada K, Nishimura T, Fukui K
  • Organizer: International Anxiety Disorder Symposium (IADS) 2011
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2011-05-24
• [Presentation] 臨床研究で画像を取り扱うコツ (2011)
  • Author(s): 成本 迅
  • Organizer: 第21回日本臨床精神神経薬理学会．第41回日本神経精神薬理学会合同年会．(招待講演)
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] 安静時fMRIを用いた無投薬強迫性障害患者における線条体‐視床機能結合の変化． (2011)
  • Author(s): 酒井雄希，成本 迅，西田誠司，中前 貴，山田 惠，西村恒彦，福居顯二．
  • Organizer: 第107回日本精神神経学会学術総会．
  • Place of Presentation: ホテル・グランパシフィック・ダイバ（東京都）
• [Presentation] Altered functional connectivity between the bilateral prefrontal cortex in obsessive-compulsive disorder. (2011)
  • Author(s): Nakamae T, Narumoto J, Sakai Y, Nishida S, Yamada K, Nishimura T, Fukui K.
  • Organizer: International Anxiety Disorder Symposium (IADS) 2011.
  • Place of Presentation: アムステルダム（オランダ）
• [Presentation] 強迫性障害の症状次元と関連する神経基盤について―脳血流SPECTを用いた検討―．
  • Author(s): 伊藤 惇，成本 迅，酒井雄希，西田誠司，中前 貴，奥山智緒，山田 惠，福居顯二．
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸