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A study on autonomic nervous system activities during sleep and the prognosis of major depression

Research Project

Project/Area Number 23591726
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKitasato University

Principal Investigator

MIYAOKA Hitoshi  北里大学, 医学部, 教授 (40209862)

Co-Investigator(Kenkyū-buntansha) TAGAYA Hirokuni  北里大学, 医療衛生学部, 教授 (50342928)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsうつ病 / 自律神経 / 予後
Research Abstract

Previous studies have shown that incidence of depression or its severity is associated with autonomic nerves system activities. But no study on autonomic nerves system activities as a marker for prognosis of depression has been performed yet. This study aims to examine to what extent changes in the autonomic nervous system during sleep in the early treatment can predict the prognosis of depression treatment, by using major depression patients who meet DSM-4 diagnostic criteria and by measuring autonomic nervous system activities during their sleep. In the antidepressant efficacy cases, it was speculated that parasympathetic components during sleep may improve from the early stage, but this study shows a tendency that parasympathetic component during sleep is inhibited.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results) (of which Invited: 1 results) Book (4 results)

  • [Journal Article] Higher cortisol levels at diurnal trough predict greater attentional bias towards threat in healthy young adults.2013

    • Author(s)
      Hakamata Y, Izawa S, Sato E, Komi S, Murayama N, Moriguchi Y, Hanakawa T, Inoue Y, Tagaya H.
    • Journal Title

      J Affect Disord

      Volume: 151(2) Issue: 2 Pages: 775-9

    • DOI

      10.1016/j.jad.2013.06.031

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropsychological Detection of the Early Stage of Amnestic Mild Cognitive Impairment without Objective Memory Impairment.2012

    • Author(s)
      Murayama N, et al.
    • Journal Title

      Dementia and Geriatric Cognitive Disorders

      Volume: 35 Issue: 1-2 Pages: 98-105

    • DOI

      10.1159/000346286

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intelligence or years of education: which is better correlated with memory function in normal elderly Japanese subjects?2012

    • Author(s)
      Murayama N, et al.
    • Journal Title

      Psychogeriatrics

      Volume: 13 Issue: 1 Pages: 9-16

    • DOI

      10.1111/j.1479-8301.2012.00408.x

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] アンチグラフを用いて調べた睡眠指標と空腹時血糖およびHbAlcとの関連―労働者を対象とした検討―2012

    • Author(s)
      田中美加, 金子新子, 鎌田直樹, 田ヶ谷浩邦
    • Journal Title

      産業精神保健

      Volume: 20(3) Pages: 250-258

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] アクチグラフを用いて調べた睡眠指標と空腹時血糖およびHbA1cとの関連 -労働者を対象とした検討-2012

    • Author(s)
      田中美加、金子新子、鎌田直樹、田ヶ谷浩邦
    • Journal Title

      産業精神保健

      Volume: 20(3) Pages: 250-258

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brief Morning Exposure to Bright Light Improves Subjective Symptoms and Performance in Nurses with Rapidly Rotating Shifts2011

    • Author(s)
      Tanaka K, Takahashi M, Tanaka M, Takanao T, Nishinoue N, Kaku A, Kato N, Tagaya H, Miyaoka H
    • Journal Title

      Journal of Occupational Health

      Volume: 53 Issue: 4 Pages: 258-266

    • DOI

      10.1539/joh.L10118

    • NAID

      130004447543

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between Autonomic Nervous System Activity during Sleep and Fasting Glucose in Japanese Workers2011

    • Author(s)
      Kamata N, Tanaka K, Morita S, Tagaya H, Kawashima M, Shichiri M, Miyaoka H
    • Journal Title

      Industrial Health

      Volume: 49 Issue: 4 Pages: 427-433

    • DOI

      10.2486/indhealth.MS1257

    • NAID

      130004483490

    • ISSN
      0019-8366, 1880-8026
    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 睡眠・精神とメラノプシン2013

    • Author(s)
      田ヶ谷浩邦
    • Organizer
      第49回日本眼光学学会総会シンポジウム3メラノプシンとロービジョン
    • Place of Presentation
      京都
    • Year and Date
      2013-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳糖代謝量に左右差がある軽度認知障害と初期アルツハイマー病の記憶機能の特徴2013

    • Author(s)
      村山憲男, 井関栄三, 田ヶ谷浩邦, 太田一実, 笠貫浩史, 藤城弘樹, 佐藤潔, 新井平伊
    • Organizer
      第28回日本老年精神医学会
    • Place of Presentation
      大阪
    • Year and Date
      2013-06-05
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Glucose tolerance were not affected by acute sleep enhancement by ultra-short acting hypnotics in healthy young males2013

    • Author(s)
      Tagaya H, Kumagai Y, Kuroyama M, Wakisaka M, Sato M, M. M
    • Organizer
      World Sleep 2013
    • Place of Presentation
      Baltimore, MA.USA
    • Year and Date
      2013-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 超短時間型BZ系およびnon-BZ系睡眠薬服用によるPVTへの影響は、服用12時間後には消失したが、DSSTスコア低下は残存していた2013

    • Author(s)
      田ヶ谷浩邦, 熊谷雄治, 黒山政一, 袴田優子, 村山憲男
    • Organizer
      日本睡眠学会第38回定期学術集会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Glucose tolerance were not affected by acute sleep enhancement by ultra-short acting hypnotics in healthy young malesdministration

    • Author(s)
      Tagaya H, Kumagai Y, Kuroyama M, Wakisaka M, Sato M, M. M.
    • Organizer
      worldsleep2013
    • Place of Presentation
      Baltimore, MA USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 睡眠・精神とメラノプシン

    • Author(s)
      田ヶ谷浩邦
    • Organizer
      第49回日本眼光学学会総会 シンポジウム3
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 睡眠相遅延症候群(睡眠相後退症候群)脳とこころのプライマリーケア3こころと身体の相互作用2013

    • Author(s)
      田ヶ谷浩邦 (編集 : 宮岡等, 日野原重明)
    • Related Report
      2013 Final Research Report
  • [Book] 高照度光療法.メンタル医療―原因解明と診断,治療の最前線―2013

    • Author(s)
      田ヶ谷浩邦, 村山憲男, 袴田優子 (編集:糸川昌成)
    • Related Report
      2013 Final Research Report
  • [Book] 脳とこころのプライマリケア3 こころと身体の相互作用2013

    • Author(s)
      田ヶ谷浩邦、宮岡等、日野原重明、他
    • Total Pages
      607
    • Publisher
      シナジー
    • Related Report
      2013 Annual Research Report
  • [Book] メンタル医療 -原因解明と診断, 治療の最前線-2013

    • Author(s)
      田ヶ谷浩邦、 村山憲男、 袴田優子、糸川昌成、他
    • Total Pages
      221
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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