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A study on treatment, prevention, and medical safty of delirium

Research Project

Project/Area Number 23591728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionJuntendo University

Principal Investigator

HATTA Kotaro  順天堂大学, 医学部, 准教授 (90337915)

Co-Investigator(Kenkyū-buntansha) KISHI Yasuhiro  日本医科大学, 医学部, 教授 (60256930)
ODAWARA Toshinari  横浜市立大学, 大学病院, 准教授 (00244426)
TAKEUCHI Takashi  東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (70345289)
SUGITA Manabu  順天堂大学, 医学部, 准教授 (20322414)
USUI Chie  順天堂大学, 医学部, 准教授 (70453587)
KAMIJO Yoshito  北里大学, 医学部, 教授 (90255266)
MACHIDA Yutaka  順天堂大学, 医学部, 准教授 (90317470)
Co-Investigator(Renkei-kenkyūsha) NAKAMURA Hiroyuki  金沢大学, 医学部, 教授 (30231476)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsせん妄 / 予防 / 予測 / 治療 / ラメルテオン / メラトニン / 抗精神病薬 / ナチュラル・キラー細胞 / ナチュラルキラー細胞 / ランダム化比較試験 / 嚥下性肺炎 / コンジョイント分析 / リスペリドン / クエチアピン / ランダム化臨床試験 / インターロイキン1β
Outline of Final Research Achievements

First, we have demonstrated preventive effects of ramelteon, a melatonin agonist, on delirium through a randomized placebo-controlled trial. This finding supports a possible pathogenic role of melatonin neurotransmission in delirium. This accomplishment may provide a paradigm shift from treatment to prevention in clinical practice of delirium. Second, we have demonstrated the predictive value of a change in natural killer cell activity for delirium. The importance of delirium prediction may increase as we have developed an effective prevention method. Third, we have demonstrated that in the general hospital setting under management including fine dosage adjustment in individual patients and the early detection of side-effects, antipsychotics have a low risk in the treatment of patients with delirium, and have high efficacy.
These findings such as prevention, prediction, and treatment will provide clinical guidelines for delirium.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (38 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 4 results) Presentation (16 results) (of which Invited: 10 results) Book (4 results)

  • [Journal Article] せん妄の治療と対策2014

    • Author(s)
      八田耕太郎
    • Journal Title

      臨床精神医学

      Volume: 43 Pages: 847-852

    • Related Report
      2014 Annual Research Report
  • [Journal Article] せん妄2014

    • Author(s)
      八田耕太郎
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 935-937

    • Related Report
      2014 Annual Research Report
  • [Journal Article] その不眠をどう治療するか、あるいは治療しないか-せん妄-2014

    • Author(s)
      八田耕太郎
    • Journal Title

      精神科治療学

      Volume: 29 Pages: 1387-1392

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 臨床試験データをどう臨床に活かすか2014

    • Author(s)
      八田耕太郎
    • Journal Title

      臨床精神医学

      Volume: 43 Pages: 1749-1753

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial2014

    • Author(s)
      Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H; DELIRIA-J Group
    • Journal Title

      JAMA Psychiatry

      Volume: 71 Issue: 4 Pages: 397-403

    • DOI

      10.1001/jamapsychiatry.2013.3320

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The predictive value of a change in natural killer cell activity for delirium.2014

    • Author(s)
      Hatta K, Kishi Y, Takeuchi T, Wada K, Odawara T, Usui C, Machida Y, Nakamura H, for the DELIRIA-J Group
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 48 Pages: 26-31

    • DOI

      10.1016/j.pnpbp.2013.09.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients : a prospective observational study2014

    • Author(s)
      Hatta K, Kishi Y, Wada K, Odawara T, Takeuchi T, Shiganami T, Tsuchida K, Oshima Y, Uchimura N, Akaho R, Watanabe A, Taira T, Nishimura K, Hashimoto N, Usui C, Nakamura H
    • Journal Title

      Int J Geriatr Psychiatry

      Volume: 29(3) Issue: 3 Pages: 253-262

    • DOI

      10.1002/gps.3999

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] せん妄の原因,診断,治療の原則2013

    • Author(s)
      八田耕太郎
    • Journal Title

      精神科治療学

      Volume: 28 Pages: 985-990

    • Related Report
      2013 Research-status Report
  • [Journal Article] せん妄の診立てと治療2013

    • Author(s)
      八田耕太郎
    • Journal Title

      精神経誌

      Volume: 115 Pages: 1150-1156

    • Related Report
      2013 Research-status Report
  • [Journal Article] Three core domains of delirium validated using exploratory and confirmatory factor analyses2013

    • Author(s)
      Franco JG, Trzepacz PT, Meagher DJ, Kean J, Lee Y, Kim JL, Kishi Y, Furlanetto LM, Negreiros D, Huang MC, Chen CH, Leonard M, de Pablo J
    • Journal Title

      Psychosomatics

      Volume: 54 Issue: 3 Pages: 227-238

    • DOI

      10.1016/j.psym.2012.06.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高齢者によくみられる精神症状の鑑別診断と治療 せん妄2013

    • Author(s)
      岸泰宏
    • Journal Title

      日本臨床

      Volume: 71 Pages: 1738-1742

    • Related Report
      2013 Research-status Report
  • [Journal Article] せん妄のスクリーニングと症状評価に用いる尺度2013

    • Author(s)
      岸泰宏
    • Journal Title

      精神科治療学

      Volume: 28 Pages: 1115-1121

    • Related Report
      2013 Research-status Report
  • [Journal Article] 心臓血管手術と術後譫妄を考える 術後せん妄の診断と対応2013

    • Author(s)
      岸泰宏
    • Journal Title

      Cardiovascular Anesthesia

      Volume: 17 Pages: 9-16

    • Related Report
      2013 Research-status Report
  • [Journal Article] コンサルテーション・リエゾン精神医療とせん妄2013

    • Author(s)
      竹内 崇
    • Journal Title

      臨床精神医学

      Volume: 17 Pages: 491-495

    • Related Report
      2013 Research-status Report
  • [Journal Article] せん妄の非薬物療法的アプローチ2013

    • Author(s)
      竹内 崇
    • Journal Title

      精神科治療学

      Volume: 28 Pages: 1049-1054

    • Related Report
      2013 Research-status Report
  • [Journal Article] せん妄時の身体合併症と事故防止のために2013

    • Author(s)
      岡村泰、金子友子、小田原俊成
    • Journal Title

      精神科治療学

      Volume: 28 Pages: 1129-1136

    • Related Report
      2013 Research-status Report
  • [Journal Article] 入院患者のうつ病・認知症2013

    • Author(s)
      小田原俊成
    • Journal Title

      レジデントノート

      Volume: 15 Pages: 2382-2447

    • Related Report
      2013 Research-status Report
  • [Journal Article] せん妄の治療指針の作成2013

    • Author(s)
      八田耕太郎
    • Journal Title

      臨床精神医学

      Volume: 42 Pages: 355-360

    • Related Report
      2012 Research-status Report
  • [Presentation] Preventive effects of ramelteon on delirium in patients with mild cognitive impairment or dementia2015

    • Author(s)
      Hatta K
    • Organizer
      17th International Psychogeriatric Association (IPA) International Congress
    • Place of Presentation
      Berlin
    • Year and Date
      2015-10-13 – 2015-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Preventive effects of ramelteon on delirium2015

    • Author(s)
      Hatta K
    • Organizer
      3rd Annual Conference of the European Association of Psychosomatic Medicine
    • Place of Presentation
      Nuremberg
    • Year and Date
      2015-07-02 – 2015-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] “Treatment, prevention, and prediction of delirium2015

    • Author(s)
      Hatta K
    • Organizer
      2015 Korean Psychosomatic Society spring meeting
    • Place of Presentation
      Seoul
    • Year and Date
      2015-06-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] コンジョイント分析によるせん妄治療コンセンサス2014

    • Author(s)
      八田耕太郎
    • Organizer
      第27回日本総合病院精神医学会総会
    • Place of Presentation
      つくば・つくば国際会議場
    • Year and Date
      2014-11-28 – 2014-11-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] がん患者の難治性症状としてのせん妄予防の可能性2014

    • Author(s)
      八田耕太郎
    • Organizer
      第24 回日本臨床精神神経薬理学会・ 第44回日本神経精神薬理学会 合同年会
    • Place of Presentation
      名古屋・名古屋国際会議場
    • Year and Date
      2014-11-20 – 2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] DELIRIA-J2014

    • Author(s)
      八田耕太郎
    • Organizer
      第24 回日本臨床精神神経薬理学会・ 第44回日本神経精神薬理学会 合同年会
    • Place of Presentation
      名古屋・名古屋国際会議場
    • Year and Date
      2014-11-20 – 2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Preventive effects of ramelteon on delirium2013

    • Author(s)
      Kotaro Hatta, Yasuhiro Kishi, Takashi Takeuchi et al.
    • Organizer
      The 11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] The predictive value of change in natural killer cell activity for delirium2013

    • Author(s)
      Kotaro Hatta, Yasuhiro Kishi, Takashi Takeuchi et al.
    • Organizer
      The 11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] せん妄の診立てと治療2013

    • Author(s)
      八田耕太郎
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Invited
  • [Presentation] せん妄の治療指針改訂のための多施設共同研究の成果と課題2013

    • Author(s)
      八田耕太郎
    • Organizer
      第26回日本総合病院精神医学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ラメルテオンのせん妄予防効果に関する多施設共同プラセボ対照ランダム化臨床試験2013

    • Author(s)
      八田耕太郎,岸泰宏,和田健,竹内崇,小田原俊成,臼井千恵,中村裕之
    • Organizer
      第26回日本総合病院精神医学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] せん妄の診断と評価スケール2013

    • Author(s)
      岸泰宏
    • Organizer
      第26回日本総合病院精神医学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] せん妄の薬物療法2013

    • Author(s)
      竹内 崇
    • Organizer
      第26回日本総合病院精神医学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 認知症の幻覚妄想.夕暮れ症候群とせん妄2013

    • Author(s)
      小田原俊成
    • Organizer
      第32回日本認知症学会
    • Place of Presentation
      松本
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 指針改訂に向けたせん妄治療研究.WS3:せん妄の治療指針改訂に向けて2011

    • Author(s)
      八田耕太郎
    • Organizer
      第24回日本総合病院精神医学会総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] 心疾患に配慮したマネジメント

    • Author(s)
      竹内 崇
    • Organizer
      第70回日本循環器心身医学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 今日の治療指針2016年版:せん妄,手術後精神障害(ICU症候群)2016

    • Author(s)
      八田耕太郎(山口徹,北原光夫監修)
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] ナースの精神医学 改訂4版:リエゾン精神医学2015

    • Author(s)
      八田耕太郎(上島国利, 渡辺雅幸, 榊恵子編)
    • Total Pages
      358
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 精神科臨床エキスパート 他科からの依頼患者の診方と対応:意識障害・せん妄2015

    • Author(s)
      八田耕太郎(中村純編)
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 中外医学社2012

    • Author(s)
      八田耕太郎,岸泰宏
    • Total Pages
      172
    • Publisher
      病棟・ICUで出会うせん妄の診かた
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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