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Correlation between Morphologic Changes and Autism Spectrum Tendency in Obsessive-Compulsive Disorder

Research Project

Project/Area Number 23591733
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

NAKAGAWA AKIKO  千葉大学, 医学(系)研究科(研究院), 特任教授 (70253424)

Co-Investigator(Kenkyū-buntansha) YOSHIURA Takashi  鹿児島大学, 医歯(薬)学総合研究科, 教授 (40322747)
HIRANO Yoshiyuki  千葉大学, 大学院医学研究院, 特任講師 (50386843)
MIYAZAKI Tetsuji  川崎医科大学, 医学部, 講師 (50412185)
伊東 克能  川崎医科大学, 医学部, 教授 (00274168)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsOCD / ASD / VBM / DLPFC / Amygdala / AQ / 強迫性障害 / 広汎性発達障害 / D-YBOCS / AQ-J / DTI / OCD、連合王国
Outline of Final Research Achievements

Objectives: In this study we investigated the Autistic Spectrum Disorders (ASD) tendency of OCD patients from a neuroimaging point of view using voxel-based morphometry. Methods: We investigated the regional volume difference between OCD patients (n=20) and healthy controls (n=30) as well as the correlation between Autism-Spectrum Quotient (AQ) scores and regional cerebral volumes of OCD patients. Results: OCD patients showed significantly decreased volumes in bilateral middle frontal gyri compared to controls. Correlational analysis showed significant positive correlations between AQ scores and regional Grey matter (GM) volumes in the left dorsolateral prefrontal cortex (DLPFC) and left amygdala. Furthermore, the GM volumes of these regions were positively correlated with each other. Conclusion: ASD traits in OCD patients were positively correlated with regional GM volumes in left DLPFC and amygdala, which could contribute to the heterogeneity of symptoms of OCD patients.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Correlation between morphologic changes and autism spectrum tendency in obsessive-compulsive disorder2015

    • Author(s)
      Tomoko Kobayashi, Yoshiyuki Hirano, Kiyotaka Nemoto, Chihiro Sutoh, Kazuhiro Ishikawa, Haruko Miyata, Junko Matsumoto, Koji Matsumoto, Yoshitada Masuda, Michiko Nakazato, Eiji Shimizu,and Akiko Nakagawa
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: -

    • NAID

      130005108990

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 強迫性障害の認知行動療法2013

    • Author(s)
      中川彰子
    • Journal Title

      最新精神医学

      Volume: 18 Pages: 35-44

    • Related Report
      2013 Research-status Report
  • [Journal Article] 強迫性障害ー今、何が問題になっているか2012

    • Author(s)
      中川彰子
    • Journal Title

      臨床精神医学

      Volume: 41 Pages: 5-12

    • Related Report
      2011 Research-status Report
  • [Presentation] 強迫性障害における自閉傾向と脳の形態との関連2014

    • Author(s)
      小林 智子、 平野 好幸、 根本 清貴、 須藤千尋、宮田 はる子、松本淳子、 浅野 憲一、中里 道子、 清水 栄司、中川 彰子
    • Organizer
      第41回日本脳科学会
    • Place of Presentation
      福井県県民ホール(福井県福井市)
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Correlation between regional gray matter volume and autistic traits in obsessive-compulsive disorder (OCD).2014

    • Author(s)
      .Nakagawa A, Hirano Y, Kobayashi T, Miyata H, Matsumoto J, Asano K, Matsumoto K, Nemoto K, Masuda Y, Nakazato M, Shimizu E
    • Organizer
      44th European Association for Behavioural and Cognitive Therapies Congress
    • Place of Presentation
      The Hague(Nederland)
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical Feature of Obsessive-Compulsive Disorder with Pervasive Developmental Disorder2013

    • Author(s)
      Nakagawa A, Isomura K, Hiraoka Y, Takei Y, Nakatani E, Yoshioka K, Tomita M, Aoki S
    • Organizer
      The 7th World Congress of Behavioral and Cognitive Psychotherapies
    • Place of Presentation
      Lima (Peru)
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinical Features of Obsessive-Compulsive Disorder with Pervasive Developmental Disorder2011

    • Author(s)
      Akiko Nakagawa, Yoko Yamashita, Yuko Takei et al
    • Organizer
      41st annual EABCT Congress
    • Place of Presentation
      Raykjavik, Iceland
    • Related Report
      2011 Research-status Report
  • [Remarks] 子どものこころの発達研究センター

    • URL

      http://www.m.chiba-u.ac.jp/class/rccmd/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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