An exploration for the reason about accumulation of Vitronectin in the mouse model of Tauopathy

• Project/Area Number: 23591735
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: MARUYAMA masahiro 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (80396481)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: ビトロネクチン / タウモデルマウス / 脳萎縮 / ビトロネクチン受容体 / タウオパチーモデルマウス / タウオパチー / 中枢神経分子マーカー / インテグリン受容体 / 再ミエリン化 / 神経修復機構 / オリゴデンドロサイト前駆細胞 / 歯状回分子層 / 中枢疾患分子マーカー

Research Abstract

The accumulation of vitronectin(Vn) in the perforant pathway of hippocampal area was found in PS19 tau mice. The hippocampus of PS19 mice has been known as the primary region of pathology with hyperphosphorylated tau accumulation. Interestingly, less Vn showed more hippocampal atrophy in the PS19 mice. Crossbreeding of the PS19 mice with Vn null mice confirmed the enhanced hippocampal atrophy. These findings suggest that Vn may have a protective function against the neuronal loss in PS19 mice.

Research Products

• [Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls (2013)
  • Author(s): Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.
  • Journal Title: Neuron Volume: 79 Issue: 6 Pages: 1094-1108
  • DOI: 10.1016/j.neuron.2013.07.037
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison of the binding characteristics of [^<18>F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology (2013)
  • Author(s): Ryuichi Harada
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 40 Issue: 1 Pages: 125-132
  • DOI: 10.1007/s00259-012-2261-2
  • Peer Reviewed
• [Journal Article] PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders. (2011)
  • Author(s): Higuchi M, Maeda J, Ji B, Tokunaga M, Zhang MR, Maruyama M, Ono M, Fukumura T, Suhara T.
  • Journal Title: Curr Top Behav Neurosci. Volume: epub ahead of print
  • Peer Reviewed
• [Presentation] 接着分子ビトロネクチンによるタウ病態の制御 (2013)
  • Author(s): 丸山将浩
  • Organizer: 2013タウ研究ミーティング
  • Place of Presentation: 愛知
  • Year and Date: 2013-08-09
• [Presentation] 接着分子ビトロネクチンによるタウ病態の制御 (2013)
  • Author(s): 丸山 将浩
  • Organizer: 2013 タウ研究ミーティング
  • Place of Presentation: あいち健康プラザ
• [Presentation] 接着性タンパクvitronectinがタウ病理と神経変性に及ぼす影響 (2012)
  • Author(s): 丸山将浩
  • Organizer: 2012タウ研究ミーティング
  • Place of Presentation: 京都
  • Year and Date: 2012-06-10
• [Presentation] 接着性タンパクvitronectinがタウ病理と神経変性に及ぼす影響 (2012)
  • Author(s): 丸山 将浩
  • Organizer: タウ研究ミーティング
  • Place of Presentation: 同志社大学