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Comorbidity and daytime function of patients with narcolepsy

Research Project

Project/Area Number 23591739
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNeuropsychiatric Research Institute

Principal Investigator

HAYASHIDA KENICHI  公益財団法人神経研究所, 研究部, 研究員 (30338933)

Co-Investigator(Kenkyū-buntansha) OZAKI Akiko  東邦大学, 看護学部, 教授 (30305429)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsナルコレプシー / カタプレキシー / 情動脱力発作 / 診断 / 発症 / QOL / 周期性四肢運動障害 / 中枢性過眠症 / 特発性過眠症 / 睡眠関連運動障害 / 睡眠関連呼吸障害 / レム睡眠行動障害 / 過眠症 / 睡眠学 / 睡眠障害
Research Abstract

Narcolepsy with Cataplexy (NA-CA) was shown to be complicated with REM sleep behavior disorder and/or Periodic leg movement during sleep (PLMS) possibly due to depressomotor function during sleep, which is influenced by dysfunction of orexin neurons (Hcrt-1). NA-CA with PLMS was characterized by a disrupted nocturnal sleep, however, PLMS did not seem to affect daytime sleepiness and quality of life (QOL) of patients affected with NA-CA.
In order to promote early diagnosis and treatment of NA, improvement of the access to information about both the concept of the disorder and medical institutions specialized in sleep disorders via the Internet would be desirable.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Differences in brain morphological findings between narcolepsy with and without cataplexy2013

    • Author(s)
      Nakamura M, Nishida S, Hayashida K, Ueki Y, Dauvilliers Y, Inoue Y
    • Journal Title

      PLoS One

      Volume: 8(11)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Factors Associated with Duration Before Receiving Definitive Diagnosis of Narcolepsy among Japanese Patients Affected with the Disorder.2013

    • Author(s)
      Ueki Y, Hayashida K, Komada Y, Nakamura M, Kobayashi M, Iimori M, Inoue Y.
    • Journal Title

      Int J Behav Med.

      Volume: 印刷中 Issue: 6 Pages: 966-970

    • DOI

      10.1007/s12529-013-9371-5

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in brain morphological findings between narcolepsy with and without cataplexy.2013

    • Author(s)
      Nakamura M, Nishida S, Hayashida K, Ueki Y, Dauvilliers Y, Inoue Y.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 11 Pages: e81059-e81059

    • DOI

      10.1371/journal.pone.0081059

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ナルコレプシー患者の確定診断期間に影響する因子について2014

    • Author(s)
      植木洋一郎、林田健一、井上雄一
    • Organizer
      第39回日本睡眠学会定期学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] 過眠症サブグループにおける睡眠関連運動障害および呼吸障害の合併についての検討2014

    • Author(s)
      木下明彦、笹井妙子、井上雄一
    • Organizer
      第39回日本睡眠学会定期学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 閉塞性睡眠時無呼吸症候群における呼吸関連指標の自然経過に関する検討2012

    • Author(s)
      林田健一、小林美奈、難波一義、植木洋一郎、樋上茂、井上雄一
    • Organizer
      第37回日本睡眠学会定期学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Invited
  • [Presentation] 行動誘発性睡眠不足症候群2012

    • Author(s)
      林田健一
    • Organizer
      第37回日本睡眠学会定期学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 遠隔睡眠医療による睡眠医療連携にむけての課題

    • Author(s)
      林田健一
    • Organizer
      日本睡眠学会第36回定期学術集会(招待講演)
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Book] 睡眠とその障害のクリニカルクエスチョン2002014

    • Author(s)
      林田健一
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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