| Project/Area Number |
23591742
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
ZHAO SONGJI 北海道大学, 医学(系)研究科(研究院), 教授 (80374239)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIJIMA Kenichi 北海道大学, 大学院医学研究科, 特任講師 (60364254)
TAKEI Toshiki 北海道大学, 大学院医学研究科, 助教 (60374493)
SHIGA Tohru 北海道大学, 大学院医学研究科, 准教授 (80374495)
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| Co-Investigator(Renkei-kenkyūsha) |
KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | がん分子イメージング / がんの分子標的療法 / 細胞増殖 / 血管新生 / PET/CT / SPECT/CT / ＰＥＴ / ＳＰＥＣＴ |
|---|
| Research Abstract |
An early and accurate identification of the tumor response to therapy with molecular targeted drugs is indispensable for selecting optimal personalized treatment strategies. Thus, in this study we utilized molecular imaging technologies including PET and SPECT for visualizing tumor proliferation and angiogenesis/hypoxia, and demonstrated their usefulness in determining the tumor response to molecular targeted drugs at an earlier time stage using animal models. We also demonstrated the potential of our novel candidate compound for angiogenesis imaging in in vitro and in vivo studies. The present results could provide important evidence that may lead to the development of a novel diagnostic and assessment tool for measuring the tumor response to treatment with molecular targeted drugs, taking advantage of molecular imaging technologies for visualizing changes in tumor pathological states at the molecular and cellular levels.
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