Biomarker exploration of VEGF inhibitor (bevacizumab) in lung cancer

• Project/Area Number: 23591750
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: KYOICHI Kaira 群馬大学, 医学(系)研究科(研究院), 講師 (40400783)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: べバシズマブ / VEGF / FDG-PET / 肺癌 / FDG PET / 血管新生阻害 / PET

Research Abstract

The level of FDG accumulation within lung cancer cells was closely associated with glucose metabolism (Glut1) and hypoxia(HIF-1). In vitro and in vivo studies, the uptake of FDG within tumor cells showed a mild change after bevacizumab monotherapy, but that markedly revealed a significant reduction after combination of paclitaxel and bevacizumab. Moreover, we had planed a clinical trial to examine the therapeutic monitoring of platinum-based regimens plus bevacizumab for patients with lung cancer. The results suggest that FDG-PET is useful tool to evaluate the treatment response after the regimens including bevacizumab in patients with lung cancer.

Research Products

• [Journal Article] Prognostic impact of F-FDG uptake on PET in non0small cell lung cancer patients with postoperative recurrence following platinum-based chemotherapy (2014)
  • Author(s): Kaira K, Yamamoto N, Kenmotsu H, et al
  • Journal Title: Respir Investig Volume: 52(2) Pages: 121-8
• [Journal Article] 18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms (2014)
  • Author(s): Kaira K, Yamamoto N, Endo M, et al
  • Journal Title: Oncol Rep Volume: 31(1) Pages: 209-15
• [Journal Article] Biological significance of 18F-FDG uptake on PET in patients with non-small-cell lung cancer (2014)
  • Author(s): Kaira K, Serizawa M, Koh Y, et al
  • Journal Title: Lung Cancer Volume: 83(2) Pages: 197-204
• [Journal Article] Biological significance of 18F-FDG uptake on PET in patients with non-small-cell lung cancer. (2014)
  • Author(s): Kaira K, Serizawa M, Koh Y, Takahashi T, Yamaguchi A, Hanaoka H, Oriuchi N, Endo M, Ohde Y, Nakajima T, Yamamoto N.
  • Journal Title: Lung Cancer Volume: 83 Issue: 2 Pages: 197-204
  • DOI: 10.1016/j.lungcan.2013.11.025
  • Peer Reviewed
• [Journal Article] Prognostic impact of 18F-FDG uptake on PET in non-small cell lung cancer patients with postoperative recurrence following platinum-based chemotherapy. (2014)
  • Author(s): Kaira K, Yamamoto N, Kenmotsu H, Murakami H, Ono A, Naito T, Endo M, Takahashi T.
  • Journal Title: Respiratory investigation Volume: 52 Issue: 2 Pages: 121-8
  • DOI: 10.1016/j.resinv.2013.08.008
  • Peer Reviewed
• [Journal Article] 18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms. (2014)
  • Author(s): Kaira K, Yamamoto N, Endo M, Kenmotsu H, Naito T, Ono A, Murakami H, Ohde Y, Nakajima T, Takahashi T.
  • Journal Title: Oncology Reports Volume: 31 Issue: 1 Pages: 209-15
  • DOI: 10.3892/or.2013.2816
• [Journal Article] Phase II study of oral S-1 plus cisplatin with bevacizumab for advanced non-squamous non-small cell lung cancer (2013)
  • Author(s): Kaira K, Tomizawa Y, Yoshino R, et al
  • Journal Title: Lung Cancer Volume: 82(1) Pages: 103-8
• [Journal Article] Phase II study of oral S-1 and cisplatin with concurrent radiotherapy for locally advanced non-small-cell lung cancer (2013)
  • Author(s): Kaira K, Tomizawa Y, Yoshino R, et al
  • Journal Title: Lung Cancer Volume: 82(3) Pages: 449-54
• [Journal Article] Biological Correlation of 18F-FDG Uptake on PET in Pulmonary Neuroendocrine Tumors (2013)
  • Author(s): Kaira K, Murakami H, Endo M, et al
  • Journal Title: Anticancer Res Volume: 33(10) Pages: 4219-28
• [Journal Article] Phase II study of oral S-1 plus cisplatin with bevacizumab for advanced non-squamous non-small cell lung cancer. (2013)
  • Author(s): Kaira K, Tomizawa Y, Yoshino R, Miura Y, Yoshii A, Iwasaki Y, Koga Y, Ono A, Hisada T, Minato K, Sato K, Kazama T, Ishihara S, Kohyama K, Fueki N, Saito R, Sunaga N
  • Journal Title: Lung Cancer Volume: 82 Issue: 1 Pages: 103-8
  • DOI: 10.1016/j.lungcan.2013.07.008
  • Peer Reviewed
• [Journal Article] Biological correlation of 18F-FDG uptake on PET in pulmonary neuroendocrine tumors. (2013)
  • Author(s): Kaira K, Murakami H, Endo M, Ohde Y, Naito T, Kondo H, Nakajima T, Yamamoto N, Takahashi T.
  • Journal Title: Anticancer Research Volume: 33 Pages: 4219-28
• [Journal Article] Clinicopathological Significance of L-type Amino Acid Transporter 1 (LAT1) Expression in Patients with Adenoid Cystic Carcinoma. (2013)
  • Author(s): Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Kanai Y, Oyama T, Chikamatsu K.
  • Journal Title: Pathology and Oncology Research Volume: March 21
  • Peer Reviewed
• [Journal Article] 18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm : a clinicopathological study (2012)
  • Author(s): Kaira K, Abe M, Nakagawa K, et al
  • Journal Title: Eur J Radiol Volume: 81(9) Pages: 2423-9
• [Journal Article] F-FDG uptake on PET could be a predictive marker of excision repair cross-complementation group 1 (ERCC1) expression in patients with thoracic neoplasms? (2012)
  • Author(s): Kaira K, Endo M, Shukuya T, et al
  • Journal Title: Neoplasma Volume: 59(3) Pages: 257-63
• [Journal Article] Relationship between 18F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma (2012)
  • Author(s): Kaira K, Serizawa M, Koh Y, et al
  • Journal Title: Eur J Cancer Volume: 48(8) Pages: 1244-54
• [Journal Article] Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer. (2012)
  • Author(s): Kaira K
  • Journal Title: Br J Cancer Volume: 107 Issue: 4 Pages: 632-638
  • DOI: 10.1038/bjc.2012.310
  • Peer Reviewed
• [Journal Article] Kaira K, Serizawa M, Koh Y, Takahashi T, Hanaoka H, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N. (2012)
  • Author(s): Relationship between 18F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma.
  • Journal Title: European Journal of Cancer Volume: 48 Issue: 8 Pages: 1244-54
  • DOI: 10.1016/j.ejca.2012.01.016
  • Peer Reviewed
• [Journal Article] MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. (2011)
  • Author(s): Kaira K, Murakami H, Serizawa M, Koh Y, Abe M, Ohde Y, Takahashi T, Kondo H, Nakajima T, Yamamoto N.
  • Journal Title: Virchows Arch. Volume: 458 Pages: 615-20
  • Peer Reviewed
• [Journal Article] Expression of Excision Repair Cross-Complementation Group 1, Breast Cancer Susceptibility 1, and β III-Tubulin in Thymic Epithelial Tumors. (2011)
  • Author(s): Kaira K, Serizawa M, Koh Y, Miura S, Kaira R, Abe M, Nakagawa K, Ohde Y, Okumura T, Naito T, Murakami H, Takahashi T, Kondo H, Nakajima T, Endo M, Yamamoto N.
  • Journal Title: J Thorac Oncol. Volume: 6 Pages: 606-13
  • Peer Reviewed
• [Journal Article] Correlation between 18F-FDG uptake on PET and molecular biology in metastatic pulmonary tumors. (2011)
  • Author(s): Kaira K, Okumura T, Ohde Y, Takahashi T, Murakami H, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N
  • Journal Title: J Nucl Med Volume: 52 Pages: 705-11
  • Peer Reviewed
• [Journal Article] Expression of thymidylate synthase, orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in thymic epithelial tumors. (2011)
  • Author(s): Kaira K, Serizawa M, Koh Y, Miura S, Kaira R, Abe M, Nakagawa K, Ohde Y, Okumura T, Murakami H, Tsuya A, Nakamura Y, Naito T, Takahashi T, Kondo H, Nakajima T, Endo M, Yamamoto N.
  • Journal Title: Lung Cancer. Volume: 74 Pages: 419-25
  • Peer Reviewed
• [Journal Article] Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors. (2011)
  • Author(s): Kaira K, Ohde Y, Endo M, Nakagawa K, Okumura T, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Kondo H, Nakajima T, Yamamoto N.
  • Journal Title: Oncol Rep Volume: 26 Pages: 931-7
  • Peer Reviewed
• [Journal Article] Prognostic significance of thymidylate synthase expression in the adjuvant chemotherapy after resection for pulmonary metastases from colorectal cancer. (2011)
  • Author(s): Kaira K, Okumura T, Ohde Y, Takahashi T, Murakami H, Kondo H, Nakajima T, Yamamoto N.
  • Journal Title: Anticancer Res Volume: 31 Pages: 2763-71
  • Peer Reviewed
• [Journal Article] LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer. (2011)
  • Author(s): Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N.
  • Journal Title: Am J Transl Res. Volume: 3 Pages: 468-78
  • Peer Reviewed
• [Journal Article] Relationship between LAT1 expression and response to platinum-based chemotherapy in non-small cell lung cancer patients with postoperative recurrence. (2011)
  • Author(s): Kaira K, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Oriuchi N, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N.
  • Journal Title: Anticancer Res. Volume: 31 Pages: 3775-82
  • Peer Reviewed
• [Presentation] 悪性胸膜中皮腫におけるFDG集積の生物学的特性 (2013)
  • Author(s): 解良恭一
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2013-04-19
• [Presentation] 切除不能局所進行非小細胞肺癌におけるCDDP＋TS-1と胸部放射線同時併用療法の第I/II相試験 (2013)
  • Author(s): 解良恭一、富澤由雄、吉野麗子、吉井明弘、久田剛志、石塚全、前野敏孝、白井克幸、斎藤淳一、江原威、松浦正名、砂長則明
  • Organizer: 第54回日本肺癌学会総会
  • Place of Presentation: ホテルニューオータニ東京
• [Presentation] 悪性胸膜中皮腫におけるFDG集積の生物学的特性 (2013)
  • Author(s): 解良恭一、芹澤昌邦、洪泰浩、高橋利明、遠藤正浩、砂長則明、岩崎康樹、久田剛志、石塚全、山本信之
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 悪性胸膜中皮腫における18F-FDG集積の生物学的特性 (2013)
  • Author(s): 解良恭一
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 東京
• [Presentation] 切除不能局所進行非小細胞肺癌におけるCDDP+TS-1と胸部放射線同時併用療法の第I/II相試験 (2011)
  • Author(s): 解良恭一
  • Organizer: 第54回日本肺癌学会総会
  • Place of Presentation: ホテルニューオータニ東京(東京都)
  • Year and Date: 2011-11-22
• [Presentation] 胸腺上皮腫瘍における18F-FDG-PETの臨床病理学的意義. (2011)
  • Author(s): 解良恭一, 遠藤正浩, 解良梨恵子, 三浦理, 中村有希子, 津谷あす香, 剣持広和, 内藤立暁, 村上晴泰, 高橋利明, 山本信之.
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フオーラム