Study on the development and clinical utility of high-resolution MR endoscopy
| Project/Area Number |
23591753
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMADA Ichiro 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (90182518)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Jiro 東京医科歯科大学, 大学院保健衛生学研究科, 准教授 (80280973)
ITO Eisaku 東京医科歯科大学, 医学部附属病院, 助教 (80345298)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | MRI / 内視鏡 / MR内視鏡 / 高分解能 / 病理組織学 |
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| Outline of Final Research Achievements |
We developed the methods of high-resolution MR endoscopy (MRE) using a 3-T clinical MRI unit and a 7-T experimental MRI unit. The methods of high-resolution MRE were optimized using the experimental phantoms, experimental animals, and organ tissues resected from those patients who had various kinds of tumors. In order to develop high-resolution diffusion-weighted MRE, we performed diffusion-tensor imaging (DTI) and q-space imaging (QSI) in gastrointestinal tumors. We demonstrated the feasibility of high-resolution diffusion-weighted MRE to obtain the histopathologic information of tumors. Furthermore, we demonstrated that the high-resolution diffusion-weighted MRE is useful for tissue characterization, assessing depth of tumor invasion, diagnosing lymph node metastasis, and staging tumors.
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] 血管造影とSASItestの解離により局在診断に難渋したNETの1例2013
Author(s)
大木葉宣昭, 南勲, 三原正朋, 泉山肇, 吉本貴宣, 伴大輔, 落合高徳, 入江工, 富井翔平, 伊藤栄作, 明石巧, 田邉稔, 小川佳宏
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Journal Title
日本内分泌学会雑誌
Volume: 89
Pages: 984-984
Related Report
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[Journal Article] ESDを施行した胃底腺型腺癌の1例2013
Author(s)
藤本祐未, 荒木昭博, 金子俊, 河合富貴子, 加納嘉人, 後藤文男, 仁部洋一, 新田沙由梨, 長堀正和, 岡田英理子, 大塚和朗, 渡辺守, 天野与稔, 伊藤栄作, 河内洋, 江石義信
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Journal Title
Progress of Digestive Endoscopy
Volume: 82
Pages: 144-146
NAID
Related Report
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[Journal Article] 急性腎不全, 低K血症, 血栓性微小血管症を呈し, 緊急透析導入を要した2例2013
Author(s)
石本育栄, 伊藤栄作, 都嵜祥人, 吉崎幸, 安藤史顕, 日下敬太, 佐塚美幸, 飯盛聡一郎, 大井克征, 桑名仁, 油井直文, 蘇原映誠, 岡戸丈和, 野田裕美, 頼建光, 内田信一, 佐々木成
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Journal Title
臨床体液
Volume: 40
Pages: 27-32
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[Presentation] q-Space diffusion-weighted MR imaging of gastric carcinoma ex vivo: correlation with histopathologic findings.2014
Author(s)
Yamada I, Hikishima K, Miyasaka N, Kato K, Ito E, Kojima K, Kawano T, Kobayashi D, Eishi Y, Okano H
Organizer
The 100th Scientific Assembly and Annual Meeting of the Radiological Society of North America
Place of Presentation
Chicago, USA
Year and Date
2014-11-30 – 2014-12-05
Related Report
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[Presentation] Esophageal carcinoma: evaluation with diffusion-tensor MR imaging and tractography ex vivo.2013
Author(s)
Yamada I, Hikishima K, Miyasaka N, Tokairin Y, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H, Shibuya H
Organizer
The 99th Scientific Assembly and Annual Meeting of the Radiological Society of North America
Place of Presentation
Chicago, USA
Related Report
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[Presentation] Ultra-high-field (7.0-T) MR imaging of esophageal carcinoma ex vivo: correlation of high-spatial-resolution MR images and histopathologic findings.2013
Author(s)
Yamada I, Miyasaka N, Hikishima K,Tokairin Y, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H, Shibuya H
Organizer
The 99th Scientific Assembly and Annual Meeting of the Radiological Society of North America
Place of Presentation
Chicago, USA
Related Report
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