| Project/Area Number |
23591753
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMADA Ichiro 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (90182518)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Jiro 東京医科歯科大学, 大学院保健衛生学研究科, 准教授 (80280973)
ITO Eisaku 東京医科歯科大学, 医学部附属病院, 助教 (80345298)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | MRI / 内視鏡 / MR内視鏡 / 高分解能 / 病理組織学 |
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| Outline of Final Research Achievements |
We developed the methods of high-resolution MR endoscopy (MRE) using a 3-T clinical MRI unit and a 7-T experimental MRI unit. The methods of high-resolution MRE were optimized using the experimental phantoms, experimental animals, and organ tissues resected from those patients who had various kinds of tumors. In order to develop high-resolution diffusion-weighted MRE, we performed diffusion-tensor imaging (DTI) and q-space imaging (QSI) in gastrointestinal tumors. We demonstrated the feasibility of high-resolution diffusion-weighted MRE to obtain the histopathologic information of tumors. Furthermore, we demonstrated that the high-resolution diffusion-weighted MRE is useful for tissue characterization, assessing depth of tumor invasion, diagnosing lymph node metastasis, and staging tumors.
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