| Project/Area Number |
23591762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Mie University |
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Principal Investigator |
SAKUMA HAJIME 三重大学, 医学(系)研究科(研究院), 教授 (60205797)
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Kakuya 三重大学, 医学部附属病院, 助教 (50378353)
NAGATA Motonori 三重大学, 医学部附属病院, 助教 (40402028)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | MRI / Myocardial Strain / DENSE MRI / SENC MRI / Ischemic Heart Disease / Myocardial Infarction / Myocardium / Strain / Magnetic Resonance / Sweden / 国際情報交換 / スウェーデン / 心筋 / ストレイン / 壁運動 / 心筋梗塞 / DENSE / SENC |
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| Research Abstract |
The purposes of this study were (1) to developed and optimize displacement encoding with stimulated echo (DENSE) MRI for reproducible quantification of myocardial strain, (2) to compare regional myocardial strain determined by strain encoded (SENC) MRI with the value obtained by speckle tracking echocardiography, and (3) to determine if speckle tracking analysis of cine MRI can provide assessment of altered myocardial strain in patients with myocardial infarction by using DENSE MRI as a reference standard. We found that (1) use of spiral acquisition reduced artifact on DENSE MRI and allows for reproducible quantification of circumferential and radial strain, (2) longitudinal myocardial strain of the right ventricle can be accurately assessed with SENC MRI and (3) speckle tracking of cine MRI and DENSE MRI demonstrated an excellent agreement and moderate agreement for global and regional myocardial strain, respectively, in patients with myocardial infarction.
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