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Minimally invasive response evaluation in vivo for the dual therapy of the angiogenesis inhibitors

Research Project

Project/Area Number 23591763
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionShiga University of Medical Science

Principal Investigator

SHINICHI Ota  滋賀医科大学, 医学部, 講師 (30583637)

Co-Investigator(Kenkyū-buntansha) SONODA Akinaga  滋賀医科大学, 医学部, 助教 (00571051)
新田 哲久  滋賀医科大学, 医学部, 講師 (40324587)
Co-Investigator(Renkei-kenkyūsha) NITTA Norihisa  滋賀医科大学, 医学部, 講師 (40324587)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords血管新生阻害薬 / 抗腫瘍効果 / 画像評価 / 病理評価
Research Abstract

The anti-tumor effect of the angiogenesis inhibitors increased in the following order; bevacizumab, sorafenib, and thalidomide. The anti-tumor effects of the dual therapies except sorafenib and thalidomide were lower than those of the single therapies. However, the numbers of the dual therapies were not enough to consider them, therefore, more studies about the dual therapies were necessary. When the anti-tumor effect of the angiogenesis inhibitor was determined, the best and simple way was to measure the change of the tumor sizes before and after the therapy using CT. To measure the change of enhancement ratio using CT / DSA and to evaluate the necrosis ratio and the numbers of tumor vessels pathologically were unfitted for the response evaluation of the angiogenesis inhibitors.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] ウサギ肝腫瘍モデルを用いたソラフェニブ併用肝動脈塞栓の治療効果の検討2014

    • Organizer
      第43回日本IVR学会総会
    • Place of Presentation
      奈良
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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