| Project/Area Number |
23591771
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kagawa University |
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Principal Investigator |
AGA Fumitoshi 香川大学, 医学部附属病院, その他 (30596078)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuka 香川大学, 医学部附属病院, 講師 (30335872)
NISHIYAMA Yoshihiro 香川大学, 医学部, 教授 (50263900)
KUDOMI Nobuyuki 香川大学, 医学部, 准教授 (20552045)
HOSHIKAWA Hiroshi 香川大学, 医学部, 准教授 (70294767)
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| Research Collaborator |
NORIKANE Takashi 香川大学, 医学部附属病院, 病院助教 (90623223)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 頭頸部癌 / 低酸素細胞 / PET検査 / F-18 FMISO / 分子イメージング |
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| Research Abstract |
Tumor hypoxia induces aggressiveness, increases metastatic potential, and promotes tumor progression and resistance to anticancer therapy. Hypoxia-inducible factor-1 (HIF-1) strongly influences angiogenesis, a key element in the growty of solid tumors and formation of metastases. In solid tumors including head and neck cancer, the progression has been reported to be poor if the tumor was in a hypoxic state before treatment. In-vivo measurement of hypoxia in individual patients is of clinical interest. The purpose of the study was to evaluate tumor hypoxia using F-18 FMISO PET in relation to the expression of HIF-1 in patients with head and neck cancer. Our result had weak correlation between hypoxic volume using F-18 FMISO PET and HIF-1.
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