| Project/Area Number |
23591776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
UETANI Masataka 長崎大学, 医歯(薬)学総合研究科, 教授 (40176582)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Tetsuji 長崎大学, 大学病院, 講師 (30380893)
川上 純 長崎大学, 医歯(薬)学総合研究科, 教授 (90325639)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Atsushi 長崎大学, 医歯薬学研究科, 教授 (90325639)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 関節リウマチ / MRI / 手関節 / 骨髄浮腫 / 動脈血スピンラベル法 / 滑膜炎 / 血流評価 |
|---|
| Research Abstract |
Noncontrast MRI is effective in identifying bone lesions(bone marrow edema and erosion) in the wrist and finger joints associated with synovitis in early-stage RA as well as contrast MRI. The combination of MRI-proven bone marrow edema with the 2010 ACR/EULAR RA classification criteria improves the diagnostic probability of RA at an early stage. In addition, MRI-proven bone marrow edema was proved to be an indicator of control of bone and joint damage at 1-year after the treatment. Noncontrast MRI is cost-effective, as it can be efficiently conducted with lower magnetic field MR units and does not require additional cost of contrast media. The knowledge obtained by this study is expected to enhance the clinical application of noncontrast MRI in the evaluation of early-stage RA.
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