Study of non-contrast MR imaging in evaluation of rheumatoid arthritis
Project/Area Number |
23591776
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Nagasaki University |
Principal Investigator |
UETANI Masataka 長崎大学, 医歯(薬)学総合研究科, 教授 (40176582)
|
Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Tetsuji 長崎大学, 大学病院, 講師 (30380893)
川上 純 長崎大学, 医歯(薬)学総合研究科, 教授 (90325639)
|
Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Atsushi 長崎大学, 医歯薬学研究科, 教授 (90325639)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
Keywords | 関節リウマチ / MRI / 手関節 / 骨髄浮腫 / 動脈血スピンラベル法 / 滑膜炎 / 血流評価 |
Research Abstract |
Noncontrast MRI is effective in identifying bone lesions(bone marrow edema and erosion) in the wrist and finger joints associated with synovitis in early-stage RA as well as contrast MRI. The combination of MRI-proven bone marrow edema with the 2010 ACR/EULAR RA classification criteria improves the diagnostic probability of RA at an early stage. In addition, MRI-proven bone marrow edema was proved to be an indicator of control of bone and joint damage at 1-year after the treatment. Noncontrast MRI is cost-effective, as it can be efficiently conducted with lower magnetic field MR units and does not require additional cost of contrast media. The knowledge obtained by this study is expected to enhance the clinical application of noncontrast MRI in the evaluation of early-stage RA.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion.2014
Author(s)
Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
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Journal Title
Rheumatology (Oxford).
Volume: 53
Issue: 3
Pages: 562-569
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis2014
Author(s)
Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N., Ichinose K., Arima K., Tamai M., Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
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Journal Title
Rheumatology
Volume: 22
Pages: 22-22
URL
Related Report
Peer Reviewed
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[Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion.2014
Author(s)
Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
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Journal Title
Rheumatology (Oxford)
Volume: 53
Pages: 562-569
NAID
Related Report
Peer Reviewed
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[Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis.2014
Author(s)
Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
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Journal Title
Rheumatology
Volume: 22
Pages: 22-22
Related Report
Peer Reviewed
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[Journal Article] Confirmation of effectiveness of tocilizumab by ultrasonography and magnetic resonance imaging in biologic agent-naive early-stage rheumatoid arthritis patients.2013
Author(s)
Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Kawakami A.
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Journal Title
Modern Rheumatology
Volume: Equb ahead of print
Issue: 6
Pages: 1-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach.2012
Author(s)
Kita J, Tamai M, Arima K, Kawashiri SY, Horai Y, Iwamoto N, Okada A, Koga T, Nakashima Y, Suzuki T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
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Journal Title
Mod Rheumatol
Volume: 23
Issue: 2
Pages: 254-259
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis.2012
Author(s)
Kawashiri SY, Suzuki T, Okada A, Yamasaki S, Tamai M, Nakamura H, Origuchi T, Mizokami A, Uetani M, Aoyagi K, Eguchi K, Kawakami A
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Journal Title
Mod Rheumatol
Volume: 23
Issue: 1
Pages: 36-43
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drags shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors2011
Author(s)
Kita J, Tamai M(筆頭共著者), ArimaK, Nakashima Y, Suzuki T, Kawashiri SY, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Aramaki T, Nakashima M, Fujikawa K, Tsukada T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
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Journal Title
Mod Rheumatol
Volume: (E-pub)
Issue: 2
Pages: 195-201
DOI
Related Report
Peer Reviewed
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[Journal Article] Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration2011
Author(s)
Kita J, Tamai M(筆頭共著者), ArimaK, Nakashima Y, Suzuki T, Kawashiri SY, Iwamoto N, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
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Journal Title
Mod Rheumatol
Volume: (E-pub)
Issue: 3
Pages: 346-352
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis : comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaaceticacid (Gd-DTPA)-enhanced MRI-based findings2011
Author(s)
Tamai M, Kawakami A, Uetani M, Fukushima A, Arima K, Fujikawa K, Iwamoto N, Aramaki T, Kamachi M, Nakamura H, Ida H, Origuchi T, Aoyagi K, Eguchi K
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Journal Title
Mod Rheumatol
Volume: (E-pub)
Issue: 5
Pages: 654-658
DOI
Related Report
Peer Reviewed
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[Journal Article] Magnetic resonance imaging of wrist and finger joints distinguishes secondary Sjogren's syndrome with rheumatoid arthritis from primary Sjogren's syndrome with articular manifestations2011
Author(s)
Iwamoto N, Kawakami A, Tamai M, Arima K, Nakamura H, Kawashiri SY, Kita J, Okada A, Koga T, Kamachi M, Yamasaki S, Ichise K, Inoda H, Origuchi T, Uetani M, Eguchi K
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Journal Title
Clinical and Experimental Rheumatology
Volume: 29
Issue: 3
Pages: 1062-1063
DOI
Related Report
Peer Reviewed
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[Journal Article] Magnetic resonance imaging of wrist and finger joints distinguishes secondary Sjogren's syndrome with rheumatoid arthritis from primary Sjogren's syndrome with articular manifestations.2011
Author(s)
Iwamoto N, Kawakami A, Tamai M, Arima K, Nakamura H, Kawashiri SY, Kita J, Okada A, Koga T, Kamachi M, Yamasaki S, Ichise K, Inoda H, Origuchi T, Uetani M, Eguchi K
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Journal Title
Clinical and Experimental Rheumatology
Volume: 29
Pages: 1062-1063
Related Report
Peer Reviewed
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[Journal Article] Comparative study of the detection of joint injury in early-stage rheumatoid arthritis by magnetic resonance imaging of the wrist and finger joints and physical examination.2011
Author(s)
Kita J, Tamai M, Arima K, Nakashima Y, Suzuki T, Kawashiri SY, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Aramaki T, Nakashima M, Fujikawa K, Tsukada T, Ida H, Aoyagi K, et al.
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Journal Title
Arthritis Care & Research
Volume: 63
Issue: 3
Pages: 436-439
DOI
Related Report
Peer Reviewed
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[Presentation] Combination of magneticimaging (MRI)- proven osteitis with 2010 RA classification criteria improves the diagnostic probability of rheumatoid arthritis (RA)2013
Author(s)
Tamai M, Kita K, Nakashima Y, Nishino A, Suzuki T, Horai Y, Okada A, Koga T,Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Fukushima A, Aoyagi K, Eguchi K, Kawakami A
Organizer
ACR/AHRP meeting 2012
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Stringent therapies improve both radiographic and clinical outcome in early-stage RA patients from Japanese population: longitudinal study from Nagasaki early arthritis cohort2013
Author(s)
Tamai M, Nakashima Y, Suzuki T, Kita J, Okada A, Kawashiri S, Iwamoto N,Ichinose K, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
ACR/AHRP meeting 2013
Place of Presentation
San Diego, USA
Related Report
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[Presentation] The severity of synovial inflammation assessed by musculoskeletal ultrasonography correlates with that of osteitis assessed by magnetic resonance imaging in patients with rheumatoid arthritis2013
Author(s)
Kawashiri S, Suzuki T, Nakashima Y,Horai Y, Okada A, Iwamoto N, Ichinose K,Arima K, Tamai M, Nakamura H, Origuchi T,Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
EULAR 2013
Place of Presentation
Madrid, Spain
Related Report
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[Presentation] Combination of magnetic imaging (MRI)-proven osteitis with 2010 RAclassification criteria improves the diagnostic probability of rheumatoid arthritis (RA)2013
Author(s)
Tamai M, Nakashima Y, Suzuki T, Kita J, Okada A, Kawashiri S, Iwamoto N,Ichinose K, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
EULAR 2013
Place of Presentation
Madrid, Spain
Related Report
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[Presentation] RAの寛解基準 Mriからみた寛解基準の意義2013
Author(s)
川上 純, 玉井 慎美, 川尻 真也, 中村 英樹, 折口 智樹, 上谷 雅孝, 青柳 潔, 江口 勝美
Organizer
第57回日本リウマチ学会総会・学術集会・国際リウマチシンポジウム
Place of Presentation
国立京都国際会館(京都市左京区)
Related Report
Invited
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[Presentation] リウマチ性疾患の画像 ACUSON S2000 ABVS(Automated Breast Volume Scanner)を用いた関節リウマチ患者における手指関節自動スキャンの検討.2013
Author(s)
川尻 真也, 鈴木 貴久, 中島 好一, 寶來 吉朗, 岡田 覚丈, 岩本 直樹, 一瀬 邦弘, 玉井 慎美, 有馬 和彦, 中村 英樹, 折口 智樹, 上谷 雅孝, 青柳 潔, 川上 純
Organizer
第57回日本リウマチ学会総会・学術集会・国際リウマチシンポジウム
Place of Presentation
国立京都国際会館(京都市左京区)
Related Report
-
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[Presentation] Stringent Therapies Improve Clinical, Radiographic and Magnetic Resonance Imaging Outcome In Early-Stage Rheumatoid Arthritis Patients From Japanese Population: Longitudinal Study From Nagasaki Early Arthritis Cohort.2013
Author(s)
Tamai M, Nakashima Y, Kita K, Takatani A, Nishino A, Suzuki T, Horai Y, Okada A, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Nakamura H, Origuchi T, Uetani M, Eguchi K, Kawakami A
Organizer
American College of Rheumatology, 77th Annual Meeting
Place of Presentation
The San Diego convention center(米国)
Related Report
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[Presentation] Combination Of Magnetic Resonance Imaging-Proven Osteitis With 2010 RA Classification Criteria Improves The Diagnostic Probability Of Early Rheumatoid Arthritis Whose Disease Duration Less Than 6 Months.2013
Author(s)
Tamai M, Kita K, Nakashima Y, Nishino A, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Fukushima A, Aoyagi K, Eguchi K, Kawakami A
Organizer
American College of Rheumatology, 77th Annual Meeting
Place of Presentation
The San Diego convention center(米国)
Related Report
-
[Presentation] Stringent Therapies Improve Both Radiographic And Clinical Outcome In Early-Stage RA Patients From Japanese Population: Longitudinal Study From Nagasaki Early Arthritis Cohort2013
Author(s)
Tamai M, Nakashima Y, Suzuki T, Kita J, Okada A, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
EULAR 2013
Place of Presentation
Feria de Madrid(スペイン)
Related Report
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[Presentation] The Severity Of Synovial Inflammation Assessed By Musculoskeletal Ultrasonography Correlates With That Of Osteitis Assessed By Magnetic Resonance Imaging In Patients With Rheumatoid Arthritis2013
Author(s)
Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
EULAR 2013
Place of Presentation
Feria de Madrid(スペイン)
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[Presentation] Automated Breast Volume Scanner (ABVS), A New Automated Ultrasonic Device, Is Useful To Examine Joint Injury In Patients With Rheumatoid Arthritis2013
Author(s)
Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
EULAR 2013
Place of Presentation
Feria de Madrid(スペイン)
Related Report
-
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[Presentation] Combination of magnetic imaging (MRI)- proven osteitis with 2010 RA classification criteria improves the diagnostic probability of rheumatoid arthritis (RA)2012
Author(s)
Tamai M, Nakashima Y, Suzuki T,Horai Y, Okada K, Kita J, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Nakamura H,Origuchi T, Uetani M, Aoyagi K, Eguchi K,Kawakami A
Organizer
ACR/AHRP meeting 2012
Place of Presentation
Washington, USA
Related Report
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[Presentation] The presence of magnetic resonancc imaging-proven osteitis at entry predicts the development of rapid radiographic progression in patients with early rhewmtoid arthritis2012
Author(s)
Tamai M, Nakashima Y, Suzuki T, Okada K, Kita J, Horai Y, Iwamoto N, Ichinose K,Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
EULAR2012
Place of Presentation
Berlin, Germany
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-
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[Presentation] 関節リウマチ予後における関節MRI2012
Author(s)
玉井 慎美, 有馬 和彦, 岩本 直樹, 岡田 覚丈, 喜多 潤子, 川尻 真也, 一瀬 邦弘, 中村 英樹, 川上 純,青柳 潔、上谷 雅孝、折口 智樹、江口 勝美
Organizer
第40回 日本臨床免疫学会
Place of Presentation
東京
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[Presentation] リウマチ性疾患の画像(3) 関節エコーは2010年分類基準の早期関節リウマチにおける診断能を向上させる2012
Author(s)
川尻 真也, 西野 文子, 鈴木 貴久, 中島 好一, 寶來 吉朗, 岡田 覚丈, 一瀬 邦弘, 玉井 慎美, 山崎 聡士, 中村 英樹, 川上 純,折口 智樹、青柳 潔、上谷 雅孝、江口勝美
Organizer
第56回 日本リウマチ学会総会・学術集会・国際リウマチシンポジウム
Place of Presentation
東京
Related Report
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[Presentation] The presence of magnetic resonance imaging-proven osteitis at entry predicts the development of rapid radiographic progression in patients with early rheumatoid arthritis2012
Author(s)
Tamai M, Nakashima Y, Suzuki T, Okada A, Kita J, Horai Y, Kawashiri S, Iwamoto N. Ichinose K, Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Aoyagi, Eguchi K, Kawakami A
Organizer
EULAR 2012
Place of Presentation
Berlin
Related Report
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[Presentation] Combination of Magnetic Resonance Imaging (MRI)-Proven Osteitis with 2010 RA Classification Criteria Improves the Diagnostic Probability of Rheumatoid Arthritis (RA)2012
Author(s)
Tamai M, Nakashima Y, Suzuki T, Horai Y, Okada A, Kita J, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi , Eguchi K, Kawakami A
Organizer
ACR/AHRP Annual Meeting
Place of Presentation
Washington
Related Report
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[Presentation] Evaluation of the patients with early arthritis by 2010 RA criteria in conjunction with MRI of wrists and finger joints2011
Author(s)
Tamai M, Arima K, Uetani M, Iwamoto N,Kita J, Okada A, Koga T, Kawashiri SY,Ichinose K, Yamasaki S, Nakamura H, Ida H,Origuchi T, Aoyagi K, Eguchi K, Kawakami A
Organizer
ACR/ARHP Meeting 2011
Place of Presentation
Chicago, USA
Related Report
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[Presentation] Evaluation of the patients with early arthritis by 2010 ACR/EULAR criteria in conjunction with MRI of wrists and finger joints2011
Author(s)
Tamai M, Arima K, Iwamoto N, Okada A,Kita J, Koga T, Kawashiri SY, Yamasaki S,Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
EULAR 2011
Place of Presentation
London, UK
Related Report
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[Presentation] Evaluation of the patients with early arthritis by 2010 ACR/EULAR criteria in conjunction with MRI of wrists and finger joints2011
Author(s)
Tamai M, Arima K, Iwamoto N, Okada A, Kita J, Koga T, Kawashiri SY, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
Organizer
Annual European Congress of Rheumatology EULAR 2011
Place of Presentation
London
Related Report
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[Presentation] Evaluation of the patients with early arthritis by 2010 RA criteria in conjunction with MRI of wrists and finger joints2011
Author(s)
Tamai M, Arima K, Uetani M, Iwamoto N, Kita J, Okada A, Koga T, Kawashiri SY, Ichinose K, Yamasaki S, Nakamura H, Ida H, Origuchi T, Aoyagi K, Eguchi K, Kawakami A
Organizer
ACR/ARHP Annual Scientific Meeting 2011
Place of Presentation
Chicago
Related Report
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