Evaluation of anatomical liver function in hepatectomy using SPECT/CT fused imaging

• Project/Area Number: 23591779
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: YAMASHITA Yasuyuki 熊本大学, 生命科学研究部, 教授 (60220349)
• Co-Investigator(Kenkyū-buntansha): SHIRAISHI Shinya 熊本大学, 生命科学研究部, 助教 (50433008) ; YOSHIDA Morikatsu 熊本大学, 医学部附属病院, 特任助教 (20508494) ; KAWANAKA Koichi 熊本大学, 生命科学研究部, 助教 (60398188) ; SAKAMOTO Fumi 熊本大学, 医学部附属病院, 医員 (10551252)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 画像診断学 / 生体肝移植 / 肝予備能評価 / アシアロシンチグラフィー / マルチスライスＣＴ / SPECT / SPECT/CT / 肝切除 / GSA / マルチスライスCT

Research Abstract

We proposed Liver Uptake Value (LUV) and Functional Liver Index (FLI) as quantitative indices for evaluating the regional function of liver. LUV and FLI correlated with the degree of hepatic fibrosis. The LUV of future remnant liver obtained before hepatectomy was related with the postoperative hepatic functional reserve. Moreover, we suggested that surgery can be performed safely in patients whose LUV(BSA) of the liver remnant is above 27.0.

Research Products

• [Journal Article] Diagnosis of dementia with Lewy bodies: diagnostic performance of combined 123I-IMP brain perfusion SPECT and 123I-MIBG myocardial scintigraphy. (2014)
  • Author(s): Sakamoto F, Shiraishi S, Yoshida M, Tomiguchi S, Hirai T, Namimoto T, Hashimoto M, Ikeda M, Uetani H, Yamashita Y.
  • Journal Title: Annals of Nuclear Medicine Volume: 28 Pages: 203-211
  • Peer Reviewed
• [Journal Article] Added value of high-b-value (b = 3000 s/mm2) diffusion-weighted imaging at 3 T in relation to fluid-attenuated inversion recovery images for the evaluation of cortical lesions in inflammatory brain diseases. (2013)
  • Author(s): Iwashita K, Hirai T, Kitajima M, Shigematsu Y, Uetani H, Iryo Y, Azuma M, Hayashida E, Ando Y, Murakami R, Yamashita Y.
  • Journal Title: Journal of Computer Assisted Tomography Volume: 37 Pages: 338-342
  • Peer Reviewed
• [Journal Article] Usefulness of the SPACE pulse sequence at 1.5T MR cholangiography: comparison of image quality and image acquisition time with conventional 3D-TSE sequence. (2013)
  • Author(s): Nakaura T, Kidoh M, Maruyama N, Kawahara T, Namimoto T, Sakai Y, Harada K, Yamashita Y.
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 38 Pages: 1014-1019
  • Peer Reviewed
• [Journal Article] Dynamic computed tomography of locally advanced pancreatic cancer: effect of low tube voltage and a hybrid iterative reconstruction algorithm on image quality. (2013)
  • Author(s): Yamamura S, Oda S, Utsunomiya D, Funama Y, Imuta M, Namimoto T, Hirai T, Chikamoto A, Baba H, Yamashita Y.
  • Journal Title: Journal of Computer Assisted Tomography Volume: 37 Pages: 790-796
  • Peer Reviewed
• [Journal Article] Comparison of 3D Phase-Sensitive Inversion-Recovery and 2D Inversion-Recovery MRI at 3.0 T for the Assessment of Late Gadolinium Enhancement in Patients with Hypertrophic Cardiomyopathy. (2013)
  • Author(s): Morita K, Utsunomiya D, Oda S, Komi M, Namimoto T, Hirai T, Hashida M, Takashio S, Yamamuro M, Yamashita Y.
  • Journal Title: Academic Radiology Volume: 20 Pages: 752-757
  • Peer Reviewed
• [Journal Article] Timing of the hepatic arterial phase at Gd-EOB-DTPA-enhanced hepatic dynamic MRI: Comparison of the test-injection and the fixed-time delay method. (2013)
  • Author(s): Nakamura S, Nakaura T, Kidoh M, Utsunomiya D, Doi Y, Harada K, Uemura S, Yamashita Y.
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 38 Pages: 548-554
  • Peer Reviewed
• [Journal Article] Fused 99m-Tc-GSA SPECT/CT imaging for the preoperative evaluation of postoperative liver function : can the liver uptake index predict postoperative hepatic functional reserve? (2012)
  • Author(s): Morikatsu Yoshida•Shinya Shiraishi•Fumi Sakaguchi•Daisuke Utsunomiya•Kuniyuki Tashiro•Seiji Tomiguchi•Hirohisa Okabe•Toru Beppu•Hideo Baba•Yasuyuki Yamashita
  • Journal Title: Jap J Radiol Volume: 30 Pages: 255-62
  • NAID: 210000176186
  • Peer Reviewed
• [Journal Article] A quantitative index measured on 99mTc GSA SPECT/CT 3D fused images to evaluate severe fibrosis in patients with chronic liver disease (2012)
  • Author(s): Morikatsu Yoshida•Shinya Shiraishi•Fumi Sakaguchi•Daisuke Utsunomiya•Kuniyuki Tashiro•Seiji Tomiguchi•Hirohisa Okabe•Toru Beppu•Hideo Baba•Yasuyuki Yamashita
  • Journal Title: Jap J Radiol Volume: 30 Pages: 435-41
  • NAID: 50008479769
  • Peer Reviewed
• [Journal Article] Fused 99m-Tc-GSA SPECT/CT imaging for the preoperative evaluation of postoperative liver function: can the liver uptake index predict postoperative hepatic functional reserve? (2012)
  • Author(s): Yoshida M
  • Journal Title: Jpn J radiol. Volume: 30 Pages: 255-262
  • NAID: 210000176186
  • Peer Reviewed
• [Journal Article] A quantitative index measured on 99mTc GSA SPECT/CT 3D fused images to evaluate severe fibrosis in patients with chronic liver disease. (2012)
  • Author(s): Yoshida M
  • Journal Title: Jpn J Radiol . Volume: 30 Pages: 435-441
  • NAID: 50008479769
  • Peer Reviewed
• [Journal Article] FDG-PET/CT-based gross tumor volume contouring for radiation therapy planning: an experimental phantom study. (2012)
  • Author(s): Toya R
  • Journal Title: J Radiat Res. Volume: 53 Pages: 338-341
  • Peer Reviewed
• [Journal Article] Clinical usefulness of a collimator distance dependent resolution recovery in myocardial perfusion SPECT: a clinical report from a single institute. (2011)
  • Author(s): K. Tashiro
  • Journal Title: Ann Nucl Med. Volume: 25 Pages: 133-137
  • Peer Reviewed
• [Journal Article] Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system. (2011)
  • Author(s): T. Beppu
  • Journal Title: J Gastroenterol. Volume: 46 Pages: 938-943
  • Peer Reviewed
• [Presentation] 肝切除後の静脈還流障害が肝機能に与える影響について (2013)
  • Author(s): 吉田守克、白石慎哉、坂本史、冨口静二、別府透、馬場秀夫、山下康行
  • Organizer: 第8回肝癌治療シミュレーション研究会
  • Place of Presentation: 椿山荘
  • Year and Date: 2013-09-28
• [Presentation] ^<99m>Tc-GSA SPECT/CT融合画像を用いた肝機能の定量評価について (2013)
  • Author(s): 吉田守克、白石慎哉、冨口静二、山下康行
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 術後肝不全の評価に^<99m>Tc-GSA SPECT/CTが有用であった症例 (2013)
  • Author(s): 吉田守克、白石慎哉、津田紀子、坂本史、冨口静二、別府透、馬場秀夫、山下康行
  • Organizer: 第176回日本医学放射線学会九州地方会
  • Place of Presentation: 熊本大学医学部
• [Presentation] 臨床病期N0M0の食道扁平上皮癌におけるEDG-PET/CTを用いた予後予測 (2013)
  • Author(s): 白石慎哉、坂本 史、吉田守克、津田紀子、冨口静二、山下康行
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 123I-IMP-SPECTおよび123I-MIBGを複合的に用いたDLB診断能評価 (2013)
  • Author(s): 坂本 史、白石慎哉、吉田守克、津田紀子、冨口静二、山下康行
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 悪性リンパ腫の末梢神経再発診断にFDG-PET/CT が有用であった一例 (2013)
  • Author(s): 西尾 啓、白石 慎哉、坂本 史、吉田 守克、河中 功一、山下 康行、冨口 静二
  • Organizer: 第 177 回 日本医学放射線学会九州地方会
  • Place of Presentation: 長崎大学病院
• [Presentation] 肝切除後の静脈還流障害が肝機能に与える影響について (2013)
  • Author(s): 吉田守克、白石慎哉、別府 透、坂本 史、冨口静二、馬場秀夫、山下康行
  • Organizer: 第8回肝癌治療シミュレーション研究会
  • Place of Presentation: 椿山荘東京
• [Presentation] ^<99m>Tc- Galactosyl Human Serum Albumin Scintigraphy with SPECT CT for the Assessment of Hepatic Function during Liver Regeneration after Hepatectomy (2012)
  • Author(s): 吉田守克、白石慎哉、坂本史、冨口静二、山下康行
  • Organizer: 第98回北米放射線学会
  • Place of Presentation: イリノイ州シカゴ、マコーミックプレイス
• [Presentation] ^<99m>Tc-GSA SPECT/CT融合画像を用いた肝切除術前における術後合併症の予測 (2012)
  • Author(s): 吉田守克、白石慎哉、津田紀子、坂本史、河中功一、冨口静二、別府透、馬場秀夫、山下康行
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌
• [Presentation] 心サルコイドーシスの治療効果判定および病態解明に造影MRIと67Ga SPECT/CTのマルチモダリティ診断が有用であった1例 (2012)
  • Author(s): 坂本 史
  • Organizer: 第175回日本医学放射線学会九州地方会
  • Place of Presentation: 鹿児島大学医学部鶴陵会館
• [Presentation] 99mTc-GSA SPECT/CTを用いた肝切除術前における術後合併症の予測 (2012)
  • Author(s): 吉田守克
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌・ニトリ文化ホール
• [Presentation] 123I-IMP-SPECTおよび123I-MIBGを用いたDLB診断能の評価 (2012)
  • Author(s): 坂本 史
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌・ニトリ文化ホール
• [Presentation] 肝切除前経皮的門脈塞栓術(PTPE)後の非塞栓肝領域の予備能予測について-^<99>mTc-GSA SPECT/CT融合画像の有用性- (2011)
  • Author(s): 吉田守克、白石慎哉、坂本史、冨口静二、別府透、馬場秀夫、山下康行
  • Organizer: 第6回肝癌治療シミュレーション研究会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2011-09-24
• [Presentation] ^<99m>Tc-GSA SPECT/CT 3次元融合画像を用いた術後肝再生能予測について (2011)
  • Author(s): 吉田守克、白石慎哉、坂本史、冨口静二、別府透、馬場秀夫、山下康行
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場
• [Presentation] Impact of hybrid FDG-PET/CT on gross tumor volume definition of cervical esophageal cancer: improving inter- and intra-observer Variations. (2011)
  • Author(s): R. Toya
  • Organizer: The 53rd Annual Meeting Society for Radiation Oncology
  • Place of Presentation: Miami Beach Cinvention Center (Florida, U.S.A.)
• [Presentation] Hyperplastic hematopoietic bone marrow mimicking vertebral metastases on MRI and FDG-PET studies: diagnostic value of CT and bone scintigraphy for differentiating the two entities. (2011)
  • Author(s): S. Inoue
  • Organizer: 97th Radiological Society of North America
  • Place of Presentation: McCormick Place (Chicago, U.S.A.)
• [Presentation] 子宮筋肉腫と子宮筋腫の鑑別診断におけるFDG－PETの有用性について (2011)
  • Author(s): 阪口 史
  • Organizer: The 12th Annual Symposium Japanese Society for the Advancement of Women's Imaging
  • Place of Presentation: 淡路夢舞台国際会議場（淡路市）
• [Presentation] 肝切除前PTPE後の非塞栓肝領域の予備能予測について―99mTc-GSA SPECT/CT融合画像の有用性― (2011)
  • Author(s): 吉田守克
  • Organizer: 第6回肝癌治療シミュレーション研究会
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] 脂肪を含む後縦隔腫瘍の一例 (2011)
  • Author(s): 吉田守克
  • Organizer: 第25回胸部放射線研究会
  • Place of Presentation: 下関市生涯学習プラザ（下関市）
• [Presentation] 99mTc-GSA SPECT/CT 3次元融合画像を用いた術後肝再生能予測について (2011)
  • Author(s): 吉田守克
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場（つくば市）
• [Presentation] 子宮肉腫・子宮筋腫の鑑別診断におけるFDG-PETの有用性について (2011)
  • Author(s): 阪口 史
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場（つくば市）