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Evaluation of anatomical liver function in hepatectomy using SPECT/CT fused imaging

Research Project

Project/Area Number 23591779
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKumamoto University

Principal Investigator

YAMASHITA Yasuyuki  熊本大学, 生命科学研究部, 教授 (60220349)

Co-Investigator(Kenkyū-buntansha) SHIRAISHI Shinya  熊本大学, 生命科学研究部, 助教 (50433008)
YOSHIDA Morikatsu  熊本大学, 医学部附属病院, 特任助教 (20508494)
KAWANAKA Koichi  熊本大学, 生命科学研究部, 助教 (60398188)
SAKAMOTO Fumi  熊本大学, 医学部附属病院, 医員 (10551252)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords画像診断学 / 生体肝移植 / 肝予備能評価 / アシアロシンチグラフィー / マルチスライスCT / SPECT / SPECT/CT / 肝切除 / GSA / マルチスライスCT
Research Abstract

We proposed Liver Uptake Value (LUV) and Functional Liver Index (FLI) as quantitative indices for evaluating the regional function of liver. LUV and FLI correlated with the degree of hepatic fibrosis. The LUV of future remnant liver obtained before hepatectomy was related with the postoperative hepatic functional reserve. Moreover, we suggested that surgery can be performed safely in patients whose LUV(BSA) of the liver remnant is above 27.0.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (21 results)

  • [Journal Article] Diagnosis of dementia with Lewy bodies: diagnostic performance of combined 123I-IMP brain perfusion SPECT and 123I-MIBG myocardial scintigraphy.2014

    • Author(s)
      Sakamoto F, Shiraishi S, Yoshida M, Tomiguchi S, Hirai T, Namimoto T, Hashimoto M, Ikeda M, Uetani H, Yamashita Y.
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 28 Pages: 203-211

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Added value of high-b-value (b = 3000 s/mm2) diffusion-weighted imaging at 3 T in relation to fluid-attenuated inversion recovery images for the evaluation of cortical lesions in inflammatory brain diseases.2013

    • Author(s)
      Iwashita K, Hirai T, Kitajima M, Shigematsu Y, Uetani H, Iryo Y, Azuma M, Hayashida E, Ando Y, Murakami R, Yamashita Y.
    • Journal Title

      Journal of Computer Assisted Tomography

      Volume: 37 Pages: 338-342

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of the SPACE pulse sequence at 1.5T MR cholangiography: comparison of image quality and image acquisition time with conventional 3D-TSE sequence.2013

    • Author(s)
      Nakaura T, Kidoh M, Maruyama N, Kawahara T, Namimoto T, Sakai Y, Harada K, Yamashita Y.
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 38 Pages: 1014-1019

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic computed tomography of locally advanced pancreatic cancer: effect of low tube voltage and a hybrid iterative reconstruction algorithm on image quality.2013

    • Author(s)
      Yamamura S, Oda S, Utsunomiya D, Funama Y, Imuta M, Namimoto T, Hirai T, Chikamoto A, Baba H, Yamashita Y.
    • Journal Title

      Journal of Computer Assisted Tomography

      Volume: 37 Pages: 790-796

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of 3D Phase-Sensitive Inversion-Recovery and 2D Inversion-Recovery MRI at 3.0 T for the Assessment of Late Gadolinium Enhancement in Patients with Hypertrophic Cardiomyopathy.2013

    • Author(s)
      Morita K, Utsunomiya D, Oda S, Komi M, Namimoto T, Hirai T, Hashida M, Takashio S, Yamamuro M, Yamashita Y.
    • Journal Title

      Academic Radiology

      Volume: 20 Pages: 752-757

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Timing of the hepatic arterial phase at Gd-EOB-DTPA-enhanced hepatic dynamic MRI: Comparison of the test-injection and the fixed-time delay method.2013

    • Author(s)
      Nakamura S, Nakaura T, Kidoh M, Utsunomiya D, Doi Y, Harada K, Uemura S, Yamashita Y.
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 38 Pages: 548-554

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fused 99m-Tc-GSA SPECT/CT imaging for the preoperative evaluation of postoperative liver function : can the liver uptake index predict postoperative hepatic functional reserve?2012

    • Author(s)
      Morikatsu Yoshida•Shinya Shiraishi•Fumi Sakaguchi•Daisuke Utsunomiya•Kuniyuki Tashiro•Seiji Tomiguchi•Hirohisa Okabe•Toru Beppu•Hideo Baba•Yasuyuki Yamashita
    • Journal Title

      Jap J Radiol

      Volume: 30 Pages: 255-62

    • NAID

      210000176186

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A quantitative index measured on 99mTc GSA SPECT/CT 3D fused images to evaluate severe fibrosis in patients with chronic liver disease2012

    • Author(s)
      Morikatsu Yoshida•Shinya Shiraishi•Fumi Sakaguchi•Daisuke Utsunomiya•Kuniyuki Tashiro•Seiji Tomiguchi•Hirohisa Okabe•Toru Beppu•Hideo Baba•Yasuyuki Yamashita
    • Journal Title

      Jap J Radiol

      Volume: 30 Pages: 435-41

    • NAID

      50008479769

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fused 99m-Tc-GSA SPECT/CT imaging for the preoperative evaluation of postoperative liver function: can the liver uptake index predict postoperative hepatic functional reserve?2012

    • Author(s)
      Yoshida M
    • Journal Title

      Jpn J radiol.

      Volume: 30 Pages: 255-262

    • NAID

      210000176186

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A quantitative index measured on 99mTc GSA SPECT/CT 3D fused images to evaluate severe fibrosis in patients with chronic liver disease.2012

    • Author(s)
      Yoshida M
    • Journal Title

      Jpn J Radiol .

      Volume: 30 Pages: 435-441

    • NAID

      50008479769

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] FDG-PET/CT-based gross tumor volume contouring for radiation therapy planning: an experimental phantom study.2012

    • Author(s)
      Toya R
    • Journal Title

      J Radiat Res.

      Volume: 53 Pages: 338-341

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical usefulness of a collimator distance dependent resolution recovery in myocardial perfusion SPECT: a clinical report from a single institute.2011

    • Author(s)
      K. Tashiro
    • Journal Title

      Ann Nucl Med.

      Volume: 25 Pages: 133-137

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system.2011

    • Author(s)
      T. Beppu
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 938-943

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 肝切除後の静脈還流障害が肝機能に与える影響について2013

    • Author(s)
      吉田守克、白石慎哉、坂本史、冨口静二、別府透、馬場秀夫、山下康行
    • Organizer
      第8回肝癌治療シミュレーション研究会
    • Place of Presentation
      椿山荘
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] ^<99m>Tc-GSA SPECT/CT融合画像を用いた肝機能の定量評価について2013

    • Author(s)
      吉田守克、白石慎哉、冨口静二、山下康行
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 術後肝不全の評価に^<99m>Tc-GSA SPECT/CTが有用であった症例2013

    • Author(s)
      吉田守克、白石慎哉、津田紀子、坂本史、冨口静二、別府透、馬場秀夫、山下康行
    • Organizer
      第176回日本医学放射線学会九州地方会
    • Place of Presentation
      熊本大学医学部
    • Related Report
      2013 Final Research Report
  • [Presentation] 臨床病期N0M0の食道扁平上皮癌におけるEDG-PET/CTを用いた予後予測2013

    • Author(s)
      白石慎哉、坂本 史、吉田守克、津田紀子、冨口静二、山下康行
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 123I-IMP-SPECTおよび123I-MIBGを複合的に用いたDLB診断能評価2013

    • Author(s)
      坂本 史、白石慎哉、吉田守克、津田紀子、冨口静二、山下康行
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性リンパ腫の末梢神経再発診断にFDG-PET/CT が有用であった一例2013

    • Author(s)
      西尾 啓、白石 慎哉、坂本 史、吉田 守克、河中 功一、山下 康行、冨口 静二
    • Organizer
      第 177 回 日本医学放射線学会九州地方会
    • Place of Presentation
      長崎大学病院
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝切除後の静脈還流障害が肝機能に与える影響について2013

    • Author(s)
      吉田守克、白石慎哉、別府 透、坂本 史、冨口静二、馬場秀夫、山下康行
    • Organizer
      第8回肝癌治療シミュレーション研究会
    • Place of Presentation
      椿山荘東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] ^<99m>Tc- Galactosyl Human Serum Albumin Scintigraphy with SPECT CT for the Assessment of Hepatic Function during Liver Regeneration after Hepatectomy2012

    • Author(s)
      吉田守克、白石慎哉、坂本史、冨口静二、山下康行
    • Organizer
      第98回北米放射線学会
    • Place of Presentation
      イリノイ州シカゴ、マコーミックプレイス
    • Related Report
      2013 Final Research Report
  • [Presentation] ^<99m>Tc-GSA SPECT/CT融合画像を用いた肝切除術前における術後合併症の予測2012

    • Author(s)
      吉田守克、白石慎哉、津田紀子、坂本史、河中功一、冨口静二、別府透、馬場秀夫、山下康行
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 心サルコイドーシスの治療効果判定および病態解明に造影MRIと67Ga SPECT/CTのマルチモダリティ診断が有用であった1例2012

    • Author(s)
      坂本 史
    • Organizer
      第175回日本医学放射線学会九州地方会
    • Place of Presentation
      鹿児島大学医学部鶴陵会館
    • Related Report
      2012 Research-status Report
  • [Presentation] 99mTc-GSA SPECT/CTを用いた肝切除術前における術後合併症の予測2012

    • Author(s)
      吉田守克
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌・ニトリ文化ホール
    • Related Report
      2012 Research-status Report
  • [Presentation] 123I-IMP-SPECTおよび123I-MIBGを用いたDLB診断能の評価2012

    • Author(s)
      坂本 史
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌・ニトリ文化ホール
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝切除前経皮的門脈塞栓術(PTPE)後の非塞栓肝領域の予備能予測について-^<99>mTc-GSA SPECT/CT融合画像の有用性-2011

    • Author(s)
      吉田守克、白石慎哉、坂本史、冨口静二、別府透、馬場秀夫、山下康行
    • Organizer
      第6回肝癌治療シミュレーション研究会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2011-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] ^<99m>Tc-GSA SPECT/CT 3次元融合画像を用いた術後肝再生能予測について2011

    • Author(s)
      吉田守克、白石慎哉、坂本史、冨口静二、別府透、馬場秀夫、山下康行
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of hybrid FDG-PET/CT on gross tumor volume definition of cervical esophageal cancer: improving inter- and intra-observer Variations.2011

    • Author(s)
      R. Toya
    • Organizer
      The 53rd Annual Meeting Society for Radiation Oncology
    • Place of Presentation
      Miami Beach Cinvention Center (Florida, U.S.A.)
    • Related Report
      2011 Research-status Report
  • [Presentation] Hyperplastic hematopoietic bone marrow mimicking vertebral metastases on MRI and FDG-PET studies: diagnostic value of CT and bone scintigraphy for differentiating the two entities.2011

    • Author(s)
      S. Inoue
    • Organizer
      97th Radiological Society of North America
    • Place of Presentation
      McCormick Place (Chicago, U.S.A.)
    • Related Report
      2011 Research-status Report
  • [Presentation] 子宮筋肉腫と子宮筋腫の鑑別診断におけるFDG-PETの有用性について2011

    • Author(s)
      阪口 史
    • Organizer
      The 12th Annual Symposium Japanese Society for the Advancement of Women's Imaging
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 肝切除前PTPE後の非塞栓肝領域の予備能予測について―99mTc-GSA SPECT/CT融合画像の有用性―2011

    • Author(s)
      吉田守克
    • Organizer
      第6回肝癌治療シミュレーション研究会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 脂肪を含む後縦隔腫瘍の一例2011

    • Author(s)
      吉田守克
    • Organizer
      第25回胸部放射線研究会
    • Place of Presentation
      下関市生涯学習プラザ(下関市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 99mTc-GSA SPECT/CT 3次元融合画像を用いた術後肝再生能予測について2011

    • Author(s)
      吉田守克
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 子宮肉腫・子宮筋腫の鑑別診断におけるFDG-PETの有用性について2011

    • Author(s)
      阪口 史
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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