| Project/Area Number |
23591781
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ANDO Yukio 熊本大学, 大学院生命科学研究部, 教授 (20253742)
IKEDA Manabu 熊本大学, 大学院生命科学研究部, 教授 (60284395)
TOMIGUCHI Seiji 熊本大学, 大学院生命科学研究部, 教授 (20172182)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PET / アルツハイマー病 / SPECT / 標識合成 / アミロイドーシス / 18F-EFSB / 125I-EISB / PET検査試薬 / 11C-PIB / PIB / アルツハイマー / ピッツバーグ大学 |
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| Research Abstract |
[11C]PIB was synthesized and evaluated Quality control for Clinical use. By applying purification system,Radiochemical yield was 62.7% and radiochemical purity was 95% and more. On the other hand, EMSB (1-(2-mestyl-ethoxy)-2,5bis (phenylstyryl)benzene) is newly synthesized and (1-(125I-ethoxy)-2,5-bis (phenylstyryl) benzene) [125I]-EISB was obtained. The radiochemical yield and the radiochemical purity were 80-90% and 98.4% respectively. We injected [125I]-EISB to Alzheimer model mouse and analyzed its bio-distribution (%dose/g) of [125I]-EISB in the amyloid tissues. In the animal experiments showed that the bio-distribution (%dose/g) of [125I]-EISB gave a similar to the uptake as well as fluorescent agents MSB and PIB which have done in our institute. [125I]-EISB was a promising new radio-compound for the detection of the amyloid protein and make it possible to apply it to clinical use.
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