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The correlation between FDG uptake and various oncogenes expression in pancreas cancer

Research Project

Project/Area Number 23591782
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionUniversity of Miyazaki

Principal Investigator

NAGAMACHI SHIGEKI  宮崎大学, 医学部, 准教授 (40180517)

Co-Investigator(Kenkyū-buntansha) FURUKOJI Eiji  宮崎大学, 医学部医学科, 助教 (00423723)
KIYOHARA Shogo  宮崎大学, 医学部医学科, その他 (30599585)
MIZUTANI Youichi  宮崎大学, 医学部医学科, 助教 (40599586)
KONDOU Kazuhiro  宮崎大学, 医学部医学科, 准教授 (10244196)
TAKAHASHI Nobuyasu  宮崎大学, 医学部医学科, 准教授 (20404436)
NISHII Ryuichi  宮崎大学, 医学部医学科, 講師 (60463212)
Co-Investigator(Renkei-kenkyūsha) KAWAI Keiichi  金沢大学, 医学部保健学科, 教授 (30204663)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsすい臓がん / 癌遺伝子 / RT-PCR / FDG-PET / ADC / prognosis / 膵臓癌 / FDG-PET/CT / 予後 / SUVmax / 癌遺伝子発現
Research Abstract

We examined correlation among FDG uptake indices (SUVmax), MRI diffusion index(ADC) and various oncogenes expression in pancreas cancer. In addition, we evaluated the association those parameters and prognoses.Positive weak correlations were noted among SUVmax and EGFR, Ki-67, CDH13, VEGFA, p53.The value of SUV max was significantly higher in the recurrent group compared with that of the non-recurrence group. As for ADC mean level, it was significantly lower in the recurrent group. Both CDH13 and VEGFA demonstrated significantly higher values in the recurrent group.In pancreas cancer, gene expressions such as involving in tumor-vascular proliferation and tissue adhesion were the important prognostic factor.In addition, both SUV max and ADC mean were important imaging biomarker for predicting prognosis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2013 2012 Other

All Presentation (9 results)

  • [Presentation] The correlation between SUVmax of ^<18>F-FDG PET/CT and apparent diffusion coefficients (ADC) in pancreas cancer and biliary cancer ?2013

    • Author(s)
      Shigeki Nagamachi, MD, Ryuichi Nishii, MD, Youichi Mizutani, MD Syogo Kiyohara, MD, Seigo Fujita,MD, Hideyuki Wakamatsu, MD, Shigemi Futami, MD, Shozo Tamura, MD
    • Organizer
      RSNA
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlations between FDG Uptake Indices and the Expression of Various Type Oncogenes (KRAS, BRAF, HIF-1, EGFR, CDH13, p53, Ki67, Glut 1 and Glut 3) in Biliary Cancer: A Comparison Study to MRI Diffusion Weighted Image Parameters2013

    • Author(s)
      Shigeki Nagamachi
    • Organizer
      北米放射線学会(RSNA2013)
    • Place of Presentation
      シカゴ、アメリカ合衆国
    • Related Report
      2013 Annual Research Report
  • [Presentation] Correlations between FDG uptake indices and the expression of various type oncogene (EGFR,B-RAF,HIF-1,Glut 1,Glut 3) in bile-duct cancer: Comparison with diffusion weighted MRI image parameters.2013

    • Author(s)
      Shigeki Nagamachi
    • Organizer
      第72回日本医学放射線学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Correlations between FDG uptake indices and the expression of various type oncogene (EGFR, CDH13, p53, Ki67, KRAS, BRAF, HIF-1, Glut 1 and Glut 3) in pancreas cancer : Comparison with diffusion weighted MRI image parameters2012

    • Author(s)
      Nagamachi S, Nishii R, Shibata N, Kiyohara S, Mizutani Y, Ouchida J, Tamura S, Kawai KKondo K ,Kai M, Chijiiwa K, Wakamatsu H, Fujita S
    • Organizer
      RSNA
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2012-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] The correlation between ^<18>F-FDG PET/CT and apparent diffusion coefficients (ADC) in pancreas cancer2012

    • Author(s)
      Shigeki Nagamachi, MD, Ryuichi Nishii, MD, Youichi Mizutani, MD Syogo Kiyohara, MD, Seigo Fujita, MD, Hideyuki Wakamatsu, MD, Shigemi Futami, MD, Shozo Tamura, MD
    • Organizer
      EANM
    • Place of Presentation
      Milano(Italy)
    • Year and Date
      2012-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] The correlation between FDG uptake and expression of various oncogene in pancreas or biliary-tract cancer2012

    • Author(s)
      Shigeki Nagamachi、Ryuichi Nishii、Nobuhiro Shibata、Shogo Kiyohara、Youichi Mizutani、Hideyuki Wakamatsu、Seigo Fujita、Shigemi Futami、Shozo Tamura、Keiichi Kawai、et al
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] 膵腫瘍におけるFDG集積と腫瘍遺伝子(EGFR, CDH13, p53, Ki67, Glut 1、Glut 3) 発現との相関の検討2012

    • Author(s)
      長町茂樹、西井龍一、柴田伸弘、清原省吾、水谷陽一、 大内田次郎、田村正三、川井恵一、近藤千博、 甲斐眞弘、千々岩一男、若松秀行、藤田晴吾、二見繁美、
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] Correlations between FDG uptake indices and the expression of various type oncogene (EGFR, CDH13, p53, Ki67, KRAS, BRAF, HIF-1, Glut 1 and Glut 3) in pancreas cancer: Comparison with diffusion weighted MRI image parameters.2012

    • Author(s)
      Nagamachi S, Nishii R, Shibata N, Kiyohara S, Mizutani Y, Ouchida J, Tamura S, Kawai K,Kondo K , Kai M, Chijiiwa K, Wakamatsu H, Fujita S
    • Organizer
      RSNA2012(第98回北米放射線学会)
    • Place of Presentation
      McCormick Place Chicago, Illinois (IL), United States
    • Related Report
      2012 Research-status Report
  • [Presentation] 胆道・膵臓悪性腫瘍におけるFDG集積強度と癌関連遺伝子発現程度との相関

    • Author(s)
      長町茂樹
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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