Prostate cancer in an aging society: What does MRI technology tell us about determining appropriate therapies?

• Project/Area Number: 23591792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Dokkyo Medical University
• Principal Investigator: KAJI Yasushi 獨協医科大学, 医学部, 教授 (10273947)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MRI / MR スペクトロスコピー / 前立腺 / 癌 / MR spectroscopy

Research Abstract

The purpose of this study was to improve the quality of three Tesla (3T) MR imaging and spectroscopy, whose information is helpful for determining the management of prostate cancer.
We examined the accuracy of anatomical information based on 3TMR imaging. Due to the excellent imaging contrast, the precise prostatic zonal anatomy was visualized in an analogous fashion to histological specimens. Further, dynamic contrast enhanced imaging demonstrated the accessory pudendal artery, one of the periprostatic normal variant structures. However, improvement of MR spectroscopy at 3T was very difficult because of the inequality of transmitted radiofrequency power.
We obtained the detailed anatomical structure of prostate. This will contribute greatly to pre-surgical planning.

Research Products

• [Journal Article] Prostate 3T-MR spectroscopic imaging without an endorectal surface coil using the MLEV-PRESS sequence. (2013)
  • Author(s): Takeshi Yoshizako, Koji Uchida, Shinji Hara, Yasushi Kaji, Masahiro Sumura, Mikio Igawa, Hajime Kitagaki, Mitsuhiro Uike, Tsuyoshi Matsuda
  • Journal Title: Jpn J Radiol Volume: 31 Issue: 3 Pages: 220-225
  • DOI: 10.1007/s11604-012-0165-5
  • NAID: 210000173593
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): 茂木俊一, 楫靖
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 33巻 Pages: 76-84
  • URL: http://www.jsmrm.jp/modules/journal/index.php?content_id=1
  • Peer Reviewed
• [Journal Article] PRESS法による前立腺のマルチボクセルプロトンMRS: ファントムを用いた測定時間短縮に関する検討 (2013)
  • Author(s): 茂木俊一, 楫靖, 勝又康友, 見田尊, 伊藤玲子, 池田弓恵, 大竹かおり, 堀越美代子, 北爪静香, 武井晃司, 熊坂文成, 加瀬嘉明, 山中英壽, 小倉治之, 曲友弘, 狩野臨, 富田光, 黒澤功
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 33 Pages: 76-84
  • NAID: 10031176735
  • Peer Reviewed
• [Journal Article] 画像診断の進歩-最新技術とその臨床応用：泌尿生殖器 (2013)
  • Author(s): 楫靖, 塩山靖和, 慎武, 稲村健介, 池田宏明, 比氣貞治
  • Journal Title: カレントテラピー Volume: 31 Pages: 839-843
• [Journal Article] MRIで観察する前立腺解剖 (2013)
  • Author(s): 楫靖
  • Journal Title: 臨床画像 Volume: 29 Pages: 114-119
• [Presentation] T2強調像で求めた前立腺各領域の体積の割合 (2014)
  • Author(s): 稲村健介, 楫靖
  • Organizer: 第33回日本画像医学会
  • Place of Presentation: 東京ステーションコンファレンス(東京都千代田区)
• [Presentation] 前立腺dynamic MRIによるaccessory pundendal arteryの観察 (2014)
  • Author(s): 比氣貞治, 楫靖
  • Organizer: 第32回日本画像医学会
  • Place of Presentation: 東京ステーションコンファレンス(東京都千代田区)
• [Presentation] Do T2-weighted images of the prostate gland reflect the glandular zonal anatomy precisely? (2013)
  • Author(s): Kensuke Inamura, Yasushi Kaji
  • Organizer: The 4th Asian Congress of Abdominal Radiology
  • Place of Presentation: Kaohsiung Medical University, Kaohsiung, Taiwan
• [Presentation] 前立腺癌の診断と治療のためのMRI (2013)
  • Author(s): 楫靖
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: ロイトン札幌（北海道札幌市）
  • Invited
• [Presentation] Clinical value of multiparametric MR imaging in the detection of prostate cancer. (2013)
  • Author(s): Tsutomu Tamada, Teruki Sone, Yasushi Kaji, Hiroki Higashi, Akira Yamamoto, Katsuyoshi Ito, Takeshi Fukunaga, Akihiko Kanki
  • Organizer: 99th Scientific Assembly and Annual Meeting, Radiological Society of North America
  • Place of Presentation: McCormick Place (Chicago, U.S.A)
• [Presentation] 前立腺dynamic MRIによるaccessory pundendal arteryの観察 (2013)
  • Author(s): 比氣貞治、池田宏明、塩山靖和、楫靖、安士正裕、釜井隆男
  • Organizer: 第32回日本画像医学会
  • Place of Presentation: ステーションコンファレンス東京（東京都）
• [Presentation] 教育講演 前立腺癌のMRI診断 (2013)
  • Author(s): 楫靖
  • Organizer: 第32回日本画像医学会
  • Place of Presentation: ステーションコンファレンス東京（東京都）
• [Presentation] Do T2-weighted images of the prostate gland reflect the glandular zonal anatomy precisely? (2013)
  • Author(s): Kensuke Inamura、Rika Yoshida、Yasushi Kaji
  • Organizer: The 4th Asian Congress of Abdominal Radiology
  • Place of Presentation: Kaohsiung Medical University (Kaohsiung)
• [Presentation] Multi-voxel法による前立腺プロトンMRS：不成功の原因に関する検討 (2012)
  • Author(s): 茂木俊一、楫靖、見田尊、伊藤玲子、池田弓恵、大竹かおり、山崎美代子、北爪静香、武井晃司、熊坂文成、加瀬嘉明、山中英壽、小倉治之、曲友弘、狩野臨、富田光、黒澤功
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 国立京都国際会館（京都府）
• [Presentation] 前立腺癌の最新情報ー診断から治療までー MRIを用いた前立腺癌の評価
  • Author(s): 楫靖
  • Organizer: 第47回 日本医学放射線学会秋季臨床大会
  • Place of Presentation: 下関
• [Presentation] 前立腺癌のMRI診断
  • Author(s): 楫靖
  • Organizer: 前立腺癌画像診断セミナー(招待講演)
  • Place of Presentation: 東京