Development of a chest digital tomosynthesis system for improvement of lung cancer detection

• Project/Area Number: 23591794
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kitasato University
• Principal Investigator: GOMI TSUTOMU 北里大学, 医療衛生学部, 准教授 (10458747)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Tohoru 北里大学, 医療衛生学部, 教授 (10197311) ; NOZAKI Miwako 獨協医科大学, 医学部, 教授 (30197727)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: X線 / 癌 / トモシンセシス / 肺がん

Research Abstract

We developed the ripple-artifacts reduction processing which added to a chest digital tomosynthesis image and performed fundamental experiment evaluation and clinical evaluation to inspect utility of ripple-artifacts reduction processing. We compared with a chest radiography image from fundamental evaluation and clinical evaluation (receiver operative characteristic curve analysis) and were able to significantly improve nodule detectability and specificity (p<.0001).

Research Products

• [Journal Article] Comparison of chest dual-energy subtraction digital tomosynthesis and dual-energy subtraction radiography for detection of pulmonary nodules: initial evaluations in human clinical cases. (2013)
  • Author(s): Tsutomu Gomi, Miwako Nozaki, Tohoru Takeda, Tokuo Umeda, Kazutoshi Takahashi, and Masahiro Nakajima.
  • Journal Title: Academic Radiology Volume: 20 Issue: 11 Pages: 1357-1363
  • DOI: 10.1016/j.acra.2013.08.006
  • Peer Reviewed
• [Journal Article] Comparison of metal artifact in digital tomosynthesis and computed tomography for evaluation of phantoms. (2013)
  • Author(s): Tsutomu Gomi
  • Journal Title: Journal of Biomedical Science and Engineering Volume: 6 Issue: 07 Pages: 722-731
  • DOI: 10.4236/jbise.2013.67089
  • Peer Reviewed
• [Journal Article] Comparison between chest digital tomosynthesis and computed tomography to detect artificial pulmonary nodules for screening : a phantom study (2012)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Hiroki Fujiwara, Tohoru Takeda, Kyouko Saito, Tokuo Umeda, and Kazuya Sakaguchi
  • Journal Title: The British Journal of Radiology Volume: 85(1017) Issue: 1017 Pages: e622-e629
  • DOI: 10.1259/bjr/12643098
  • Peer Reviewed
• [Journal Article] トモシンセシスの画質改善について (2012)
  • Author(s): 五味 勉、中島正弘、梅田徳男、武田 徹、齋藤京子、坂口和也、越田吉郎
  • Journal Title: 日本医用画像工学会誌 Volume: 30 Pages: 242-249
  • NAID: 130002573584
  • Peer Reviewed
• [Journal Article] The Image Quality of Cone-beam CT (2011)
  • Author(s): 五味 勉
  • Journal Title: Japanese Journal of Radiological Technology Volume: 67 Issue: 11 Pages: 1468-1472
  • DOI: 10.6009/jjrt.67.1468
  • NAID: 10030042456
  • ISSN: 0369-4305, 1881-4883
• [Presentation] Comparison of Chest Dual-energy Subtraction Digital Tomosynthesis and Dual-energy Subtraction Radiography for Detection of Pulmonary Nodules : Initial Human Study of Clinical Cases (2013)
  • Author(s): Tsutomu Gomi, Miwako Nozaki, Kazutoshi Takahashi, Masahiro Nakajima, Tokuo Umeda, Akiko Okawa
  • Organizer: RSNA 2013
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Digital breast tomosynthesis : selection of appropriate reconstruction algorithm and radiation dose (2013)
  • Author(s): Tsutomu Gomi, Akihiro Fujita, Tokuo Umeda, Tohoru Takeda, Akiko Okawa
  • Organizer: RSNA 2013
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Comparison of digital tomosynthesis and conputed tomography to evaluate prosthesis : A study on the phantom (2013)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Tokuo Umeda, Tohoru Takeda, Akiko Okawa
  • Organizer: CARS 2013
  • Place of Presentation: Heidelberg, Germany
• [Presentation] Digital breast tomosynthesis: selection of appropriate reconstruction algorithm and radiation dose. (2013)
  • Author(s): Tsutomu Gomi, Akihiro Fujita, Tokuo Umeda, Tohoru Takeda, Akiko Okawa
  • Organizer: Radiological Society of North America (RSNA)
  • Place of Presentation: シカゴ, イリノイ州, アメリカ
• [Presentation] Comparison of Chest Dual-energy Subtraction Digital Tomosynthesis and Dual-energy Subtraction Radiography for Detection of Pulmonary Nodules: Initial Human Study of Clinical Cases. (2013)
  • Author(s): Tsutomu Gomi, Miwako Nozaki, Kazutoshi Takahashi, Masahiro Nakajima, Tokuo Umeda, Akiko Okawa.
  • Organizer: Radiological Society of North America (RSNA)
  • Place of Presentation: シカゴ, イリノイ州, アメリカ
• [Presentation] Comparison of digital tomosynthesis and conputed tomography to evaluate prosthesis: A study on the phantom. (2013)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Tokuo Umeda, Tohoru Takeda, Akiko Okawa
  • Organizer: Computer Assisted Radiology and Surgery (CARS)
  • Place of Presentation: ハイデルベルク、ドイツ
• [Presentation] Pre-reconstruction of wavelet denoising processing for removing quantum noise in digital tomosynthesis of the chest (2012)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Tokuo Umeda, Akiko Okawa, Tohoru Takeda, Kazuya Sakaguchi
  • Organizer: RSNA 2012
  • Place of Presentation: Chicago, IL, USA
• [Presentation] X-ray Digital Tomosynthesis Imaging : Selection of Appropriate Reconstruction Algorithm for Orthopedic Examination (2012)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Tokuo Umeda, Akiko Okawa, Tohoru Takeda, Kazuya Sakaguchi
  • Organizer: RSNA 2012
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Comparison of chest digital tomosynthesis and computed tomography for the detection of artificial pulmonary nodules during screening : a phantom study (2012)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Tokuo Umeda, Akiko Okawa, Tohoru Takeda, Kazuya Sakaguchi
  • Organizer: CARS 2012
  • Place of Presentation: Pisa, Italy
• [Presentation] Pre-reconstruction of wavelet denoising processing for removing quantum noise in digital tomosynthesis of the chest (2012)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Tokuo Umeda, Akiko Okawa, Tohoru Takeda, Kazuya Sakaguchi
  • Organizer: Radiological Society of North America
  • Place of Presentation: McCormick Place, Chicago, IL, USA
• [Presentation] X-ray digital tomosynthesis imaging: Selection of appropriate reconstruction algorithm for orthopedic examination (2012)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Tokuo Umeda, Akiko Okawa, Tohoru Takeda, Kazuya Sakaguchi
  • Organizer: Radiological Society of North America
  • Place of Presentation: McCormick Place, Chicago, IL, USA
• [Presentation] トモシンセシスの基礎と画質特性 (2012)
  • Author(s): 五味 勉
  • Organizer: 日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜, 横浜市
  • Invited
• [Presentation] Comparison of chest dual-energy subtraction digital tomosynthesis and dual-energy subtraction radiography to detect artificial pulmonary nodules with and without calcifications : a phantom study (2011)
  • Author(s): Tsutomu Gomi, Masahiro Nakajima, Tokuo Umeda, Akiko Okawa, Tohoru Takeda, Kazuya Sakaguchi
  • Organizer: CARS 2011
  • Place of Presentation: Berlin, Germany
• [Presentation] Comparison of chest dual-energy subtraction digital tomosynthesis and dual-energy subtraction radiography to detect artificial pulmonary nodules with and without calcifications: a phantom study (2011)
  • Author(s): Tsutomu Gomi
  • Organizer: Computer Assisted Radiology and Surgery (CARS) 25th International Congress and Exhibition
  • Place of Presentation: Estrel Hotel (Berlin, Germany)
• [Book] Chapter 10 Preliminary s tudies chest x-ray digital tomosynthesis imaging. Cancer–Cares, Treatment and Preventions (2014)
  • Author(s): Tsutomu Gomi
  • Publisher: iConceptPress Ltd., Hong Kong
• [Book] Radiography: Methods, Theory and Applications. Chapter 3 Digital Tomosynthesis (2012)
  • Author(s): Tsutomu Gomi
  • Total Pages: 17
  • Publisher: Nova Science Publishers
• [Book] Recent Advances in Arthroplasty : Chapter 6 X-ray Digital Linear Tomosynthesis Imaging of Arthoroplasty (2012)
  • Author(s): Tsutomu Gomi
  • Total Pages: 14
  • Publisher: InTech