Evaluation of iodinate contrast induced nephropathy in contrast enhanced CT for patients with mild renal dysfunction and diabetes

• Project/Area Number: 23591799
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Toho University
• Principal Investigator: GOMI Tatsuya 東邦大学, 医学部, 准教授 (90266966)
• Co-Investigator(Kenkyū-buntansha): MURATA Nozomu 東邦大学, 医学部, 助教 (90516270) ; NAGAMOTO Masashi 東邦大学, 医学部, 講師 (10172561) ; KOHDA Ehiichi 東邦大学, 医学部, 教授 (80101989) ; JOKI Nobuhiko 東邦大学, 医学部, 准教授 (40349882)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 造影剤腎症 / 腎機能障害 / N-gal / 糖尿病 / 脱水 / CT

Outline of Final Research Achievements

Acute adverse reactions are a known side effect of to iodinate contrast media. Recently, iodinate contrast induced nephropathy (CIN) has become under scrutiny because it has been reported as renal dysfunction occurring after contrast medium administration, and the mortality is high. However, the evaluation of contrast induced nephropathy after contrast enhanced CT has been insufficient. This study evaluates the real incidence of contrast induced nephropathy for contrast enhanced CT. From the results of our study, the incidence of CIN seems to be low. Therefore we speculate that it is not necessary to refrain from using contrast media more than required.

Research Products

• [Journal Article] Radial MRI during free breathing in contrat-enhanced hepatobiliary phase imaging (2014)
  • Author(s): Gomi T, Nagamoto M, Hasegawa M, Tabata A, Iwasaki M, Ooka M, Murata N, Tsunoo M, Iizuka Y, Kohda E, Shiraga N
  • Journal Title: Acta Radiol Volume: 55 Issue: 1 Pages: 3-7
  • DOI: 10.1177/0284185113492720
  • Peer Reviewed
• [Journal Article] 造影剤腎症 (2014)
  • Author(s): 五味達哉，長谷川誠，益田春香，岩崎美樹子，村田 望，角尾美果，長基雅司，飯塚有応
  • Journal Title: 泌尿器外科 Volume: 27 Pages: 83-86
• [Journal Article] Advantages of using spin-echo-type radial scanning with parallel imaging of the head (2013)
  • Author(s): Hattori N, Gomi T, Nagamoto M, Hasegawa M, Murata N, Tsunoo M, Iizuka Y, Terada H, Kohda E
  • Journal Title: J Med Soc Toho Volume: 60 Pages: 198-203
  • NAID: 120006412078
  • Peer Reviewed
• [Presentation] Analysis of risk factors for contrast medium-induced nephropathy using neutrophil gelatinase-associated lipocalin (2015)
  • Author(s): Gomi T, Hasegawa M, Nagamoto M, Masuda H, Sugiyama M, Tsunoo M, Iizuka Y, Sekiguchi R
  • Organizer: 27th European Congress of Radiology
  • Place of Presentation: Austria Center Vienna, Austria
  • Year and Date: 2015-03-04 – 2015-03-08
• [Presentation] Evaluation of changes in serum creatinine due to the seasonal temperature immediately before contrast-enhanced CT (2014)
  • Author(s): Gomi T, Sugiyama M, Hasegawa M, Iwasaki M, Murata N, Tsunoo M, Nagamoto M, Iizuka Y, Sekiguchi R
  • Organizer: 26th European Congress of Radiology
  • Place of Presentation: Austria Centre Vienna, Austria
• [Book] Radiological contrast agents and radiopharmaceuticals. Side Effects of Drugs Annual 36 (2014)
  • Author(s): Gomi T, Hasegawa M
  • Total Pages: 794
  • Publisher: ELSEVIER
• [Book] Radiological contrast agents and radiopharmaceuticals. Side Effects of Drugs Annual 35 (2014)
  • Author(s): Gomi T, Hasagawa M
  • Publisher: ELSEVIER