Quantiaitive assessment of biomarker imaging for early threapeutic response to chemoradiotherapy

• Project/Area Number: 23591801
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa Medical University
• Principal Investigator: MATOBA Munetaka 金沢医科大学, 医学部, 教授 (90288308)
• Co-Investigator(Kenkyū-buntansha): TSUJI Hiroyuki 金沢医科大学, 医学部, 教授 (00155368)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 頭頸部癌 / 化学放射線療法 / 治療効果 / MRI / PET-CT / 拡散強調画像 / 予後予測 / SUVmax / PET / 頭頚部癌 / 治療効果判定 / biomarker / diffusion MRI / PET/CT

Research Abstract

The efficacy of apparent diffusion coefficient (ADC) of diffusion weighted MRI and standardized uptake value (SUV) of FDG PET-CT for prediction and early detection of treatment response and patient outcome to chemoradiotherapy in head and neck squamous cell carcinoma (HNSCC) was investigated.
The fractional changes in ADC between pre-treatment and during 3 weeks of treatment showed significant correlation with treatment response and patient outcome. In addition, the changes in SUVmax between pre-treatment and after 8weeks of treatment showed significant correlation with patinet outcome. The results suggest that the fractional changes in ADC and the changes in SUVmax are valid imaging biomarker for predicting treatment response and patinet outcome in HNSCC treated with chemoradiotherapy.

Research Products

• [Journal Article] Fractional change in apparent diffusion coefficient as an imaging biomarker for predicting treatment response in head and neck cancer treated with chemoradiotherapy (2014)
  • Author(s): Munetaka Matoba,Hiroyuki Tsuji
  • Journal Title: Am J Neuroradiol Volume: 35 Pages: 379-385
  • Peer Reviewed
• [Journal Article] 頭頸部癌の化学放射線療法における予後予測因子としてのDWIおよびPET/CTの検討 (2014)
  • Author(s): 的場宗孝、辻裕之
  • Journal Title: 臨床放射線 Volume: 59(5) Pages: 720-727
  • Peer Reviewed
• [Journal Article] 頭頚部癌に対する化学放射線療法の治療効果予測におけるMRI拡散強調画像およびPET/CTの有用性 (2011)
  • Author(s): 的場宗孝
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 31(3) Pages: 115-123
  • Peer Reviewed
• [Journal Article] 頭頚部癌に対する化学放射線療法の治療効果予測におけるMRI拡散強調画像およびPET/CTの有用性 (2011)
  • Author(s): 的場 宗孝
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 31巻3号 Pages: 115-123
  • Peer Reviewed
• [Presentation] Ability of diffusion-weighted MRI and 118F-FDG PET/CT as predictive biomarkers of locoregional control in chemoradiotherapy for head and neck cancer (2013)
  • Author(s): 的場宗孝他
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-04-11
• [Presentation] Ability of diffusion-weighted MRI and 118F-FDG PET/CT as predictive biomarkers of locoregional control in chemoradiotherapy for head and neck cancer (2013)
  • Author(s): 的場宗孝, 辻 裕之
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜:パシフィコ横浜
• [Presentation] 頭頸部癌の化学放射線療法における局所制御予測因子としてのMRI拡散強調画像およびPET/CTの検討 (2012)
  • Author(s): 的場宗孝
  • Organizer: 第36回日本頭頸部癌学会
  • Place of Presentation: 島根
  • Year and Date: 2012-06-07
• [Presentation] Efficacy of diffusion- weighted MR imaging and PET/CT for predicting and detecting early response to chemoradiotherapy in squamous cell carcinoma of head and neck (2012)
  • Author(s): Munetaka Matoba
  • Organizer: ISMRM
  • Place of Presentation: Melbourne convention & exhibition center,Australia
  • Year and Date: 2012-04-30
• [Presentation] 頭頸部癌の化学放射線療法における局所制御予測因子としてのMRI拡散強調画像およびPET/CTの検討 (2012)
  • Author(s): 的場宗孝
  • Organizer: 第36回日本頭頸部癌学会
  • Place of Presentation: 島根県松江市文化会館
• [Presentation] Efficacy of diffusion-weighted MR imaging and PET/CT for predicting and detecting early response to chemoradiotherapy in squamous cell carcinoma of head and neck (2012)
  • Author(s): Munetaka Matoba
  • Organizer: ISMRM
  • Place of Presentation: Melbourne ｃonvention&exhibition center, Australia
• [Presentation] Efficacy of diffusion- weighted MR imaging and PET/CT for predicting and detecting early response to chemoradiotherapy in squamous cell carcinoma of head and neck (2011)
  • Author(s): Munetaka Matoba
  • Organizer: RSNA
  • Place of Presentation: McComick Place,USA
  • Year and Date: 2011-11-27
• [Presentation] 頭頚部癌に対する化学放射線療法の治療効果予測におけるMRI拡散強調画像およびPET/CTの有用性 (2011)
  • Author(s): 的場宗孝
  • Organizer: 日本医学放射線学会第150回中部地方会
  • Place of Presentation: 富山
  • Year and Date: 2011-06-26
• [Presentation] 頭頚部癌に対する化学放射線療法の治療効果予測におけるMRI拡散強調画像およびPET/CTの有用性 (2011)
  • Author(s): 的場 宗孝
  • Organizer: 日本医学放射線学会 第150回中部地方会
  • Place of Presentation: 富山大学
• [Presentation] Efficacy of diffusion-weighted MR imaging and PET/CT for predicting and detecting early response to chemoradiotherapy in squamous cell carcinoma of head and neck (2011)
  • Author(s): Munetaka Matoba
  • Organizer: RSNA
  • Place of Presentation: McComick Place, USA