Quantiaitive assessment of biomarker imaging for early threapeutic response to chemoradiotherapy
| Project/Area Number |
23591801
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Hiroyuki 金沢医科大学, 医学部, 教授 (00155368)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 頭頸部癌 / 化学放射線療法 / 治療効果 / MRI / PET-CT / 拡散強調画像 / 予後予測 / SUVmax / PET / 頭頚部癌 / 治療効果判定 / biomarker / diffusion MRI / PET/CT |
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| Research Abstract |
The efficacy of apparent diffusion coefficient (ADC) of diffusion weighted MRI and standardized uptake value (SUV) of FDG PET-CT for prediction and early detection of treatment response and patient outcome to chemoradiotherapy in head and neck squamous cell carcinoma (HNSCC) was investigated.
The fractional changes in ADC between pre-treatment and during 3 weeks of treatment showed significant correlation with treatment response and patient outcome. In addition, the changes in SUVmax between pre-treatment and after 8weeks of treatment showed significant correlation with patinet outcome. The results suggest that the fractional changes in ADC and the changes in SUVmax are valid imaging biomarker for predicting treatment response and patinet outcome in HNSCC treated with chemoradiotherapy.
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Report
(4 results)
Research Products
(14 results)
