| Project/Area Number |
23591804
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kinki University |
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Principal Investigator |
ISHII Kazunari 近畿大学, 医学部附属病院, 教授 (50534103)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Takamichi 近畿大学, 医学部, 教授 (20252653)
OKADA Masahiro 近畿大学, 医学部, 講師 (20296700)
KUMANO Seishi 近畿大学, 医学部, 講師 (70335339)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 認知症 / レビー小体型認知症 / PET / アミロイド / 糖代謝 / 脳 / アルツハイマー病 / パーキンソン病 / FDG-PET / アミロイドイメージング / MRI |
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| Research Abstract |
The purpose of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the dementia with Lewy bodies (DLB) brain. Methods: Ten consecutive subjects with DLB and 10 Alzheimer disease (AD) patients who underwent both PiB-PET and FDG-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG and PiB PET images.Results: All AD patients and five DLB patients showed amyloid deposits (PiB positive). The parietotemporal and occipital metabolism in the DLB group were significantly lower than those in the AD group. In DLB patients, there were no differences in regional glucose metabolism between PiB positive and negative patients. Conclusions: In the DLB brain, decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area.
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