99mTc-MIBI SPECT and multidrug resistance-related protein in patients with ovarian cancer

• Project/Area Number: 23591806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kurume University
• Principal Investigator: KURATA Seiji 久留米大学, 医学部, 講師 (80268888)
• Co-Investigator(Kenkyū-buntansha): KAIDA Hayato 久留米大学, 医学部, 助教 (40299425) ; ISHIBASHI Masatoshi 久留米大学, 医学部, 教授 (20168256) ; USHIJIMA Kimio 久留米大学, 医学部, 准教授 (20185002) ; KAMURA Toshiharu 久留米大学, 医学部, 教授 (30152870) ; HAYABUCHI Naofumi 久留米大学, 医学部, 教授 (20108731) ; 鹿毛 政義 久留米大学, 大学病院, 教授 (80148840)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 卵巣癌 / 核医学 / 薬剤耐性 / 99mTc-MIBI / 婦人科癌 / 核医学トレーサー / 腫瘍核医学

Research Abstract

The aim of this study was to evaluate the useful of 99mTc-MIBI SPECT for functional imaging of MDR-related protein: Thirteen women with a clinical suspicion of ovarian cancer were prospective studied. After intravenous injection of 740MBq 99mTc-MIBI, SPECT imaging at 10 minutes and 2 hours was performed. On the SPECT images, tumor uptake ratio of both early and delayed images, and washout rate of 99mTc-MIBI were calculated. The expression of MDR protein was assessed in surgically excised tumors. The immunohistochemical staining was performed. Six primary ovarian cancers were proven by histopathological examination. Five of the six ovarian cancers were positive on both early and delayed images with 99mTc-MIBI SPECT. The expression of MDR-related protein was found in all tumors. The washout rate of 99mTc-MIBI showed a significant positive correlation with YB-1 expression. Early tumor uptake ratio showed a significant positive correlation with Bax expression.

Research Products

• [Journal Article] Assessment of atherosclerosis in oncologic patients using (18)F-fluoride PET/CT (2013)
  • Author(s): Kurata S, Tateishi U, Shizukuishi K, Yoneyama T, Hino A, Kaida H, Fujimoto K, Ishibashi M, Inoue T
  • Journal Title: Ann Nucl Med Volume: 27 Pages: 481-6
  • NAID: 10031183410
  • Peer Reviewed
• [Journal Article] The relationship between 18F-FDG metabolic volumetric parameters and clinicopathological factors of breast cancer (2013)
  • Author(s): Kaida H, Toh U, Hayakawa M, Hattori S, Fujii T, Kurata S, Kawahara A, Hirose Y, Kage M, Ishibashi M.
  • Journal Title: Nucl Med Commun Volume: 34 Pages: 562-70
  • Peer Reviewed
• [Journal Article] Prognostic Significance of Total Lesion Glycolysis in Patients with Advanced Non-Small Cell Lung Cancer Receiving Chemotherapy (2012)
  • Author(s): Zaizen Y, Azuma K, Kurata S, Sadashima E, Hattori S, Sasada T , Imamura Y, Kaida H, Kawahara A, Kinoshita T, Ishibashi M and Hoshino T
  • Journal Title: Eur J Radiol Volume: 81 Pages: 4179-84
  • Peer Reviewed
• [Journal Article] The relationship between GLUT-1 and vascular endothelial growth factor expression and 18F-FDG uptake in esophageal squamous cell cancer patients (2012)
  • Author(s): Kobayashi M, Kaida H, Kawahara A, Hattori S, Kurata S, Hayakawa M, Hirose Y, Uchida M, Kage M, Fujita H, Hayabuchi N, Ishibashi M
  • Journal Title: Clin Nucl Med Volume: 37 Pages: 447-52
  • Peer Reviewed
• [Journal Article] Comparison between endoscopic macroscopic classification and F-18 FDG-PET findings in gastric MALT lymphoma patients (2012)
  • Author(s): Hirose Y, Kaida H, Ishibashi M, Uozumi J, Arikawa S, Kurata S, Hayabuchi N, Nakahara
  • Journal Title: Clin Nucl Med Volume: 37 Pages: 152-7
  • Peer Reviewed
• [Journal Article] Age-related changes in pre- and postmenopausal women investigated with (18)F-fluoride PET-a preliminary study (2012)
  • Author(s): Kurata S, Shizukuishi K, Tateishi U, Yoneyama T, Hino A, Ishibashi M, Inoue T
  • Journal Title: Skeletal Radiol Volume: 41 Pages: 947-53
  • Peer Reviewed
• [Journal Article] Prognostic Significance of Total Lesion Glycolysis in Patients with Advanced Non-Small Cell Lung Cancer Receiving Chemotherapy (2012)
  • Author(s): Zaizen Y, Azuma K, Kurata S, Sadashima E, Hattori S, Sasada T , Imamura Y, Kaida H, Kawahara A, Kinoshita T, Ishibashi M and Hoshino T
  • Journal Title: Eur J Radiol Volume: 81 Pages: 4179-84
  • Peer Reviewed
• [Presentation] Age-related regional changes of skeletal metabolism in women using 18F-fluoride PET (2013)
  • Author(s): Kurata S, et al
  • Organizer: Society of Nuclear Medicine Annual Meeting
  • Place of Presentation: Vancouver, Canada
• [Presentation] 食道扁平上皮癌のFDG集積とGLUT-1，3，MVD，TAMとの関連性の検討 (2013)
  • Author(s): 廣瀬靖光，甲斐田勇人，石橋正敏，倉田精二，小林真衣子，藤田博正，米本孝二， 河原明彦，鹿毛政義，早渕尚文
  • Organizer: 日本核医学会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 発生臓器の異なる癌FDG集積とGLUT-1,Ki-67の関連の相違 (2012)
  • Author(s): 甲斐田勇人, 他
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌
• [Presentation] 食道扁平上皮癌における18F-FDG集積とbiological parameter関連性の検討 (2012)
  • Author(s): 廣瀬靖光, 他
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 18F-FDG集積とbiological parameter関連性の検討 (2012)
  • Author(s): 廣瀬靖光，甲斐田勇人，倉田精二，小林真衣子，石橋正敏，早渕尚文，河原明彦，鹿毛政義，藤田博正，米本孝二
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 発生臓器の異なる癌FDG集積とGLUT-1，Ki-67の関連の相違 (2012)
  • Author(s): 甲斐田勇人，石橋正敏，倉田精二，廣瀬靖光，藤本公則，早渕尚文，高森信三，藤田博正､中島 格，川原章彦，鹿毛政義，早川正信，服部 聡
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌
• [Presentation] Age-related changes in pre-and postmenopausal woman as demonstrated by 18F-fluoride PET (2012)
  • Author(s): Kurata S，Shizukuishi K，Tateishi U，Yoneyama T，Hino A ，Kaida H，Ishibashi M，Hayabuchi N，Inoue T．
  • Organizer: Annual Congress of the European Association of Nuclear Medicine (EANM'12)
  • Place of Presentation: Milan