PD-ECGF-targeted tumor imaging with new F-18 radiolabeled uracil derivatives
| Project/Area Number |
23591811
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Nishijima Ken-ichi 北海道大学, 医学(系)研究科(研究院), 特任講師 (60364254)
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| Co-Investigator(Kenkyū-buntansha) |
大倉 一枝 北海道医療大学, 薬学部, 教授 (60094827)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 放射性薬剤 / 癌 / チミジンホスホリラーゼ / Thymidine Phosphorylase / 血小板由来血管内皮細胞増殖因子 / 腫瘍イメージング / F-18標識合成 |
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| Outline of Final Research Achievements |
The angiogenic factor PD-ECGF/ thymidine phosphorylase (TP) is expressed at high levels in a variety of solid tumors compared with normal tissue. In this study, we aimed at the development of F-18 radiopharmaceuticals for imaging of angiogenesis.
5-fluoro analog of IIMU and BOMU, a potent inhibitor of TP studied the synthesis was performed. We have succeeded in creating new compounds for TP. However F-labeled TP inhibitor was not given. The results of this study gave an important knowledge on to creating the F-18 labeled compounds.
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Report
(4 results)
Research Products
(6 results)
